Patents by Inventor Waldemar Pfrengle

Waldemar Pfrengle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ACID ADDITION SALTS OF THE 2-[2-[[(4-METHOXY-2,6-DIMETHYLPHENYL)SULFONYL]-(METHYL)AMINO]ETHOXY]-N-METHYL-N-[3-(4-METHYLPIPERAZIN-1-YL)CYCLOHEXYL] ACETAMIDE AND THE USE THEREOF AS BRADYKININ B1 RECEPTORANTAGONISTS
    Publication number: 20130289049
    Abstract: The present invention relates to the new acid addition salts AB of the following free base of formula A or the enantiomer thereof with a physiologically acceptable acid B which is selected from among hydrochloric acid, fumaric acid and tartaric acid, as well as the polymorphs, hydrates and solvates thereof.
    Type: Application
    Filed: August 4, 2011
    Publication date: October 31, 2013
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Thorsten Pachur, Waldemar Pfrengle, Manfred Birk, Juergen Schnaubelt, Ulrike Werthmann
  • Process for the preparation of chiral 8-(3-aminopiperidin-1yl)-xanthines
    Patent number: 8541450
    Abstract: The invention relates to enantiomerically pure 3-(phthalimido)piperidines and processes for preparing enantiomerically pure 3-(phthalimido)piperidines.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: September 24, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Waldemar Pfrengle, Thorsten Pachur
  • Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
    Publication number: 20130184204
    Abstract: The present invention relates to substituted quinazolines of formula (I): wherein X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Application
    Filed: July 13, 2012
    Publication date: July 18, 2013
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Waldemar PFRENGLE, Markus FRANK, Thomas KLEIN
  • PROCESS FOR THE PREPARATION OF CHIRAL 8-(3-AMINOPIPERIDIN-1-YL)-XANTHINES
    Publication number: 20130178485
    Abstract: The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines.
    Type: Application
    Filed: March 1, 2013
    Publication date: July 11, 2013
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Waldemar PFRENGLE, Thorsten PACHUR, Thomas NICOLA, Adil DURAN
  • Process for the stereoselective preparation of bicyclic heterocycles
    Patent number: 8263768
    Abstract: The present invention relates to a process for the stereoselective preparation of compounds of general formula (I) and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for the treatment of diseases, particularly tumoral diseases as well as benign prostatic hyperplasia (BPH), diseases of the lungs and airways.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: September 11, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Markus Ostermeier, Stefan Braith, Juergen Daeubler, Guenther Huchler, Waldemar Pfrengle
  • Process for making certain compounds having B1 antagonistic activity
    Patent number: 8207335
    Abstract: The present invention relates to a method of preparing compounds of general formula I wherein m, n, R1 and R2 are defined as mentioned hereinafter, the enantiomers, the diastereomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: June 26, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Adil Duran, Markus Frank, Waldemar Pfrengle, Juergen Schnaubelt
  • 8-(3-AMINO-PIPERIDIN-1-YL)-XANTHINES, THEIR PREPARATION, AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20120142712
    Abstract: The invention relates to 8-[3-amino-piperidin-1-yl]-xanthines and the physiologically acceptable salts thereof, particularly the hydrochlorides thereof.
    Type: Application
    Filed: January 9, 2012
    Publication date: June 7, 2012
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Waldemar PFRENGLE, Peter Sieger
  • SALT FORMS OF ORGANIC COMPOUND
    Publication number: 20120129874
    Abstract: The present invention relates to novel salt forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine, a DPP-4 inhibitor and their use in pharmaceutical compositions useful in the treatment of type 2, diabetes, as well as their production.
    Type: Application
    Filed: December 22, 2009
    Publication date: May 24, 2012
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Peter Sieger, Waldemar Pfrengle
  • PROCESS FOR THE STEREOSELECTIVE PREPARATION OF BICYCLIC HETEROCYCLES
    Publication number: 20120116080
    Abstract: The present invention relates to a process for the stereoselective preparation of compounds of general formula (I) and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for the treatment of diseases, particularly tumoral diseases as well as benign prostatic hyperplasia (BPH), diseases of the lungs and airways.
    Type: Application
    Filed: July 23, 2009
    Publication date: May 10, 2012
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Markus Ostermeier, Stefan Braith, Juergen Daeubler, Guenther Huchler, Waldemar Pfrengle
  • 8-(3-amino-piperidin-1-yl)-xanthines, their preparation, and their use as pharmaceuticals
    Patent number: 8106060
    Abstract: The invention relates to 8-[3-amino-piperidin-1-yl]-xanthines and the physiologically acceptable salts thereof, particularly the hydrochlorides thereof.
    Type: Grant
    Filed: July 30, 2006
    Date of Patent: January 31, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Waldemar Pfrengle, Peter Sieger
  • Method for producing scopine esters
    Patent number: 8101763
    Abstract: The invention relates to a novel method for producing scopine esters of the general formula (1), wherein X—, R, R1, R2, R3, R4, R3?, R4?, R6 and R6? can have the meanings indicated in the claims and in the description.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: January 24, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Waldemar Pfrengle, Werner Rall, Joerg Brandenburg, Rolf Herter
  • PROCESS FOR PREPARING CYCLOALKYL-SUBSTITUTED PIPERAZINE COMPOUNDS
    Publication number: 20110301350
    Abstract: The present invention relates to a process for preparing compounds of general formula I wherein m, n, o, R1, R2 and R3 are defined as mentioned hereinafter, the enantiomers thereof and the diastereomers thereof, which are particularly suitable for preparing compounds of general formula II wherein m, o, R1, R2, R3 and R4 are defined as mentioned hereinafter. The compounds of general formula II have B1-antagonistic properties.
    Type: Application
    Filed: February 13, 2009
    Publication date: December 8, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Waldemar Pfrengle, Markus Frank, Thorsten Pachur, Guenther Huchler
  • Crystalline anhydrate with anticholinergic efficacy
    Patent number: 7968717
    Abstract: The invention relates to a new crystalline anhydrate of tiotropium bromide, processes for preparing it and its use for preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: June 28, 2011
    Assignee: Boehringer Ingelhein International GmbH
    Inventors: Waldemar Pfrengle, Peter Sieger
  • SALT FORMS OF A 6-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE DERIVATIVE, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
    Publication number: 20110130437
    Abstract: The present invention relates to salt forms of the compound 4-[(Z)-[[4-[(dimethylaminoJmethyllphenyllaminolCe-fluoro-1,2-dihydro2-oxo-3H-indol-3-ylidene)methyl]-benzenepropanoic acid which are suitable for pharmaceutical development and to a process for their manufacture.
    Type: Application
    Filed: January 22, 2009
    Publication date: June 2, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Ulrike Werthmann, Christian Kulinna, Waldemar Pfrengle, Werner Rall
  • PROCESS FOR THE MANUFACTURE OF A 6-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE DERIVATIVE
    Publication number: 20110046395
    Abstract: The present invention relates to a process for the manufacture of the compound 4-[(Z)-[[4-[(dimethylamino)methyl]phenyl]amino](6-fluoro-1,2-dihydro-2-oxo-3H-in-dol-3-ylidene)methyl]-benzenepropanoic acid and to a new intermediate for the synthesis.
    Type: Application
    Filed: January 22, 2009
    Publication date: February 24, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Werner Rall, Waldemar Pfrengle, Juergen Schnaubelt
  • Process for the preparation of chiral 8-(-3-aminopiperidin-1-yl) xanthines
    Patent number: 7820815
    Abstract: The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines. The process involves reacting a compound of the formula (III) with 3-(phthalimido)piperidine or an enantiomer thereof where X is a leaving group selected from halogens and sulphonic ester acid residues, and R1 to R3 are as defined herein, to obtain a compound of the formula (II) and deprotecting the obtained compound of the formula (II) to obtain the product xanthines.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: October 26, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Waldemar Pfrengle, Thorsten Pachur, Thomas Nicola, Adil Duran
  • NEW PROCESS FOR THE PRODUCTION OF TIOTROPIUM SALTS
    Publication number: 20100210844
    Abstract: The invention relates to a new process for preparing tiotropium salts of general formula 1 wherein X? may have the meanings given in the claims and in the specification.
    Type: Application
    Filed: April 29, 2010
    Publication date: August 19, 2010
    Applicant: BOEHRINGER INGELHEIM PHARMA GmbH & Co. KG
    Inventors: Joerg Brandenburg, Waldemar Pfrengle
  • PROCESS FOR PREPARING
    Publication number: 20100210842
    Abstract: The present invention relates to a method of preparing compounds of general formula I wherein m, n, R1 and R2 are defined as mentioned hereinafter, the enantiomers, the diastereomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases.
    Type: Application
    Filed: February 8, 2010
    Publication date: August 19, 2010
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Adil DURAN, Markus FRANK, Waldemar PFRENGLE, Juergen SCHNAUBELT
  • Method for Producing Scopine Esters
    Publication number: 20100174067
    Abstract: The invention relates to a novel method for producing scopine esters of the general formula (1), wherein X—, R, R1, R2, R3, R4, R3?, R4?, R6 and R6? can have the meanings indicated in the claims and in the description.
    Type: Application
    Filed: May 9, 2008
    Publication date: July 8, 2010
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Waldemar Pfrengle, Werner Rall, Joerg Brandenburg, Rolf Herter
  • PROCESS FOR THE PREPARATION OF CHIRAL 8-(3-AMINOPIPERIDIN-1YL)-XANTHINES
    Publication number: 20090192314
    Abstract: The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines.
    Type: Application
    Filed: March 30, 2009
    Publication date: July 30, 2009
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Waldemar PFRENGLE, Thorsten PACHUR, Thomas NICOLA, Adil DURAN