Abstract: In an example method, a system obtains a data record indicating an anticipated change in an employment status of a user at an organization, including a data field indicating an effective time of the anticipated change. At a first time prior to the effective time, the system modifies an access privilege of the user with respect to computer resources of the organization, including (i) allowing the user to perform first operations using the computer resources between the first time and a second time subsequent to the first time, and (ii) preventing the user from performing second operations using the computer resources starting at the first time. At the second time, the system further modifies the access privilege of the user, including preventing the user from performing the operations using the computer resources starting at the second time.

Abstract: An immune-suppressing nanoparticle (NP) decorated with alpha-1 acid glycoprotein (AGP), an anti-inflammatory protein, circumventing the resistance of breast tumor cells to chemotherapy in addition to suppressing the tumor metastasis and invasion is disclosed. Methods of making hyaluronic acid-chitosan nanoparticles decorated with AGP (AGP-HA NPs) by sequential ionic gelation, spray drying, and AGP-surface adsorption are also disclosed. Treatment options to strengthen the anti-cancer effects of chemotherapeutic agents and potentially improve the survival rate of patients with metastatic breast cancer using the disclosed AGP-HA NPs containing agents are also disclosed.