Patents by Inventor Walid M. Heneine

Walid M. Heneine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and kit for detecting resistance to antiviral drugs
    Patent number: 6787126
    Abstract: An assay and kit for the detection of phenotypic resistance of a retrovirus to a reverse transcriptase inhibitor drug in a biological sample. The assay is based on the direct analysis of the susceptibility of retroviral reverse transcriptase to inhibition by a reverse transcriptase inhibitor drug. The enzymatic activity of the reverse transcriptase is determined by measuring the DNA product produced when an RNA template and a first complementary DNA primer from a suitable region of the encephalomyocarditis virus genome are incubated with a biological sample containing reverse transcriptase in the presence of the drug to which resistance is being determined.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: September 7, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Walid M. Heneine, Gerardo Garcia Lerma, Shinji Yamamoto, William M. Switzer, Thomas M. Folks
  • Spumavirus isolated from humans
    Patent number: 6623952
    Abstract: The present invention comprises a spumavirus isolated from a human. More specifically, the spumavirus of the present invention was isolated from a human who had exposure to nonhuman primates. Importantly, the spumavirus of the present invention or antibodies to the spumavirus can be used to detect the presence of spumavirus or antibodies in body fluids, for pathogenicity studies of related viruses, and as a vector for gene therapies. The spumavirus of the invention can also be used for treatment of conditions in humans due to the presence of rapidly dividing cells and for recombinant live virus vaccination.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: September 23, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Paul A. Sandstrom, Thomas M. Folks, Walid M. Heneine, William M. Switzer, Jennifer Brown
  • Method and kit for detecting resistance to antiviral drugs
    Publication number: 20030148307
    Abstract: Assays and kits for the detection of phenotypic resistance of a retrovirus to reverse transcriptase inhibitor drugs in a biological sample. The assays are based on the direct analysis of the susceptibility of retroviral reverse transcriptase to inhibition by a reverse transcriptase inhibitor drug. The enzymatic activity of the reverse transcriptase is determined by measuring the DNA product produced when an RNA template and a first complementary DNA primer from a suitable region of the encephalomyocarditis virus genome are incubated with a biological sample containing reverse transcriptase in the presence of the drug to which resistance is being determined. The incubation mixture is reacted under conditions whereby the RNA template and the DNA primer will anneal and a DNA strand will be synthesized as an extension from the DNA primer if the reverse transcriptase in the sample is resistant to and not inhibited by the drug.
    Type: Application
    Filed: July 3, 2002
    Publication date: August 7, 2003
    Applicant: Department of Health & Human Services, c/o Centers of Disease Control and Prevention
    Inventors: Walid M. Heneine, Gerardo Garcia Lerma, Shinji Yamamoto, William M. Switzer, Thomas M. Folks
  • Method and composition to detect C-type retroviral infection
    Patent number: 6596478
    Abstract: The present invention comprises methods, devices and compositions for detection of endogenous retroviruses found in xenotransplant materials. The methods and compositions are suited for detection of endogenous type-C retroviruses and in particular, for porcine endogenous retrovirus, PERV.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: July 22, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Walid M. Heneine, William M. Switzer, Paul A. Sandstrom, Aprille L. Matthews, Thomas M. Folks