Patents by Inventor Walt Mahoney
Walt Mahoney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9932643Abstract: The present methods pertain to amplifying and/or detecting Staphylococcus aureus (“SA”) and methicillin-resistant Staphylococcus aureus (“MRSA”) nucleic acids based on a combined detection of ldh1 as a SA marker and mecA as a MRSA marker. In certain embodiments the methods also pertain to amplifying and/or detecting one or more SCCmec integration sites or bridge regions. Primers and probes are suitable to be used in the present methods to detect SA and MRSA simultaneously in a single reaction or in separate reactions. The amplified nucleic acid can be detected by a variety of state of the art methods, including fluorescence resonance energy transfer (“FRET”), radiolabels, enzyme labels, and the like.Type: GrantFiled: March 9, 2017Date of Patent: April 3, 2018Assignee: ELITECHGROUP B.V.Inventors: Irina A. Afonina, Yevgeniy S. Belousov, Walt Mahoney
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Publication number: 20170183717Abstract: The present methods pertain to amplifying and/or detecting Staphylococcus aureus (“SA”) and methicillin-resistant Staphylococcus aureus (“MRSA”) nucleic acids based on a combined detection of ldh1 as a SA marker and mecA as a MRSA marker. In certain embodiments the methods also pertain to amplifying and/or detecting one or more SCCmec integration sites or bridge regions. Primers and probes are suitable to be used in the present methods to detect SA and MRSA simultaneously in a single reaction or in separate reactions. The amplified nucleic acid can be detected by a variety of state of the art methods, including fluorescence resonance energy transfer (“FRET”), radiolabels, enzyme labels, and the like.Type: ApplicationFiled: March 9, 2017Publication date: June 29, 2017Inventors: Irina A. Afonina, Yevgeniy S. Belousov, Walt Mahoney
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Patent number: 9677142Abstract: The present methods pertain to amplifying and/or detecting Staphylococcus aureus (“SA”) and methicillin-resistant Staphylococcus aureus (“MRSA”) nucleic acids based on a combined detection of ldh1 as a SA marker and mecA as a MRSA marker. In certain embodiments the methods also pertain to amplifying and/or detecting one or more SCCmec integration sites or bridge regions. Primers and probes are suitable to be used in the present methods to detect SA and MRSA simultaneously in a single reaction or in separate reactions. The amplified nucleic acid can be detected by a variety of state of the art methods, including fluorescence resonance energy transfer (“FRET”), radiolabels, enzyme labels, and the like.Type: GrantFiled: May 24, 2012Date of Patent: June 13, 2017Assignee: ELITECHGROUP B.V.Inventors: Irina A. Afonina, Yevgeniy S. Belousov, Walt Mahoney
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Patent number: 9334495Abstract: Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders (“MGBs”). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs.Type: GrantFiled: November 23, 2010Date of Patent: May 10, 2016Assignee: ELITECHGROUP B.V.Inventors: Anastasia Khvorova, Annaleen Vermeulen, Rob Kaiser, Jon Karpilow, Nicolaas M. J. Vermeulen, Walt Mahoney
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Publication number: 20150275274Abstract: The present methods pertain to amplifying and/or detecting Staphylococcus aureus (“SA”) and methicillin-resistant Staphylococcus aureus (“MRSA”) nucleic acids based on a combined detection of ldh1 as a SA marker and mecA as a MRSA marker. In certain embodiments the methods also pertain to amplifying and/or detecting one or more SCCmec integration sites or bridge regions. Primers and probes are suitable to be used in the present methods to detect SA and MRSA simultaneously in a single reaction or in separate reactions. The amplified nucleic acid can be detected by a variety of state of the art methods, including fluorescence resonance energy transfer (“FRET”), radiolabels, enzyme labels, and the like.Type: ApplicationFiled: May 24, 2012Publication date: October 1, 2015Inventors: Irina A. Afonina, Yevgeniy S. Belousov, Walt Mahoney
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Patent number: 8980855Abstract: Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders (“MGBs”). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs.Type: GrantFiled: June 7, 2012Date of Patent: March 17, 2015Assignees: Elitech Holding B.V., GE Healthcare Dharmacon, Inc.Inventors: Anastasia Khvorova, Annaleen Vermeulen, Rob Kaiser, Jon Karpilow, Nicolaas M. J. Vermeulen, Walt Mahoney
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Publication number: 20120245219Abstract: Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders (“MGBs”). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs.Type: ApplicationFiled: June 7, 2012Publication date: September 27, 2012Applicants: DHARMACON, INC., ELITECH HOLDING B.V.Inventors: Anastasia Khvorova, Annaleen Vermeulen, Rob Kaiser, Jon Karpilow, Nicolaas M.J. Vermeulen, Walt Mahoney
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Patent number: 8067177Abstract: Methods are provided for amplification and monitoring of oligonucleotide amplification in which a primer has an overlap with one or more bases of a detection probe.Type: GrantFiled: March 17, 2010Date of Patent: November 29, 2011Assignee: Epoch Biosciences, Inc.Inventors: Walt Mahoney, Nicolaas M. J. Vermeulen, Irina Afonina
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Publication number: 20110172289Abstract: Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders (“MGBs”). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs.Type: ApplicationFiled: November 23, 2010Publication date: July 14, 2011Inventors: Anastasia Khvorova, Annaleen Vermeulen, Rob Kaiser, Jon Karpilow, Nicolaas M.J. Vermeulen, Walt Mahoney
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Publication number: 20110027780Abstract: Methods are provided for amplification and monitoring of oligonucleotide amplification in which a primer has an overlap with one or more bases of a detection probe.Type: ApplicationFiled: March 17, 2010Publication date: February 3, 2011Inventors: Walt Mahoney, Nicolaas M.J. Vermeulen, Irina Afonina
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Patent number: 7723038Abstract: Methods are provided for amplification and monitoring of oligonucleotide amplification in which a primer has an overlap with one or more bases of a detection probe.Type: GrantFiled: December 18, 2007Date of Patent: May 25, 2010Assignee: Elitech Holding B.V.Inventors: Walt Mahoney, Nicolaas M. J. Vermeulen, Irina Afonina
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Publication number: 20080248474Abstract: Methods are provided for amplification and monitoring of oligonucleotide amplification in which a primer has an overlap with one or more bases of a detection probe.Type: ApplicationFiled: December 18, 2007Publication date: October 9, 2008Applicant: EPOCH BIOSCIENCES, INCInventors: WALT MAHONEY, Nicolaas M.J. Vermeulen, Irina Afonina
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Patent number: 7319022Abstract: Methods are provided for amplification and monitoring of oligonucleotide amplification in which a primer has an overlap with one or more bases of a detection probe.Type: GrantFiled: August 11, 2005Date of Patent: January 15, 2008Assignee: Epoch Biosciences, Inc.Inventors: Walt Mahoney, Nicolaas M. J. Vermeulen, Irina Afonina
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Publication number: 20030095962Abstract: This invention provides a system for controlling the phenotypic characteristics of cells. A pair of chimeric polypeptides is anchored in the plasma membrane, each of which has a variable region sequence and an effector sequence. The polypeptides are independent in the absence of antigen, but form a stable complex with each other when antigen is provided. This drives the effector sequences together in a manner that produces a receptor activation signal, leading to a phenotypic change. By titrating the amount of antigen present in the environment, the degree of phenotypic change can be regulated. Cells bearing chimeric polypeptides can be used to measure the concentration of antigen or select cells transfected with a therapeutic gene.Type: ApplicationFiled: July 3, 2001Publication date: May 22, 2003Inventors: Hiroshi Ueda, Teruyuki Nagamune, Hajime Nishimura, Izumi Kumagai, Kouhei Tsumoto, Kazuo Todokoro, Paula A. Mahoney, Walt Mahoney
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Publication number: 20020045196Abstract: Methods for isolating trophoblast cells from pregnant women are provided. A central maternal blood sample is obtained, typically from the uterine wall of a pregnant woman. The trophoblast cells are isolated from the central maternal blood sample.Type: ApplicationFiled: May 12, 2000Publication date: April 18, 2002Inventors: Walt Mahoney, Paula Schueler, Douglas Yamanishi