Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: A database management engine provides a user interface that allows users to access and modify employee information in a database. The database includes entries for employees, and each database entry includes identifying information about the associated employee. A user can request to modify data within database entries, for instance in order to update information associated with an employee. Responsive to the request, the database management engine identifies liabilities associated with the database modification stemming from associated tax laws. Based on the identified tax liabilities, the engine computes the aggregate tax liability owed by the employer and/or employee. Before modifying a database entry, the engine modifies the user interface to include interface elements detailing the computed aggregate tax liability. The user explicitly can be required to confirm the database modification in view of the aggregate tax liability.

Abstract: Sensor data interpreter/converter methods and apparatus interpreting and converting sensor data transmitted by a plurality of sensors in a Low Power Wide Area Network (LPWAN) (in the up-link) in a unidirectional network and, in a bidirectional network, also converting human readable formatted information into sensor compatible machine-readable byte array data (in the downlink) are described. The interpreter/converter methods and apparatus utilize blueprints that fully define the sensors (nodes) connected in the LPWAN. The blueprints include components providing information of every possible input and output an associated sensor has. The blueprints determine how the interpreter/converter functions when converting sensor data to human readable formatted information in the uplink, and when converting human readable formatted information to sensor compatible machine-readable byte array data in the downlink. The blueprints are structured to optimize the efficiency of transmissions in limited data bandwidth LPWANs.

Abstract: A method and system for determining temperature are provided. The method comprises using an x-ray source to irradiate a sample of a material with x-rays. Photon fluorescence produced by the sample in response to the x-ray irradiation is detected by a number of photon detectors. Based on the detected fluorescence a temperature of the sample is determined according to a predetermined relationship between photon fluorescence and temperature for the material.

Abstract: An injection system for an internal combustion engine, in particular an engine operating on liquid gas as fuel or fuel component, includes an injection unit for each cylinder for direct fuel injection into the combustion chamber, and a fuel supply system with at least one fuel tank and an oscillating pump element configured as a displacer for delivery of the fuel. The pump element is provided with an elastic sealing element fitted in a housing and which divides a pump chamber into two subchambers sealed tightly against each other, the first subchamber being supplied with fuel via a fuel feed line of the fuel supply system, and the second subchamber being supplied with a secondary medium. The dead volumes of the pump element may be reduced by configuring the pump chamber as an annular chamber at least partially surrounding a shaft moving axially in a cylinder, which shaft is mechanically linked with the sealing element.

Abstract: A procedure is provided for adjusting for image line skew caused by tolerance accumulation between a Raster Output Scanning (ROS) assembly and a photoreceptor which is being scanned. The ROS housing is adjustably mounted in relation to the photoreceptor, so that incremental adjustments can be made to cause the output scan lines emerging from the ROS housing to be moved in the process or reverse process direction vis-a-vis the photoreceptor. A test print is generated which provides measurable scan delineators to identify the amount of scan line skew created by a photoreceptor misalignment. The measured scan line skew alignment is correlated with adjustments made by a hex head screw to provide a very precise alignment. The effective adjustment range is .+-.4 mm in the process direction which corresponds to .+-.6.3 milliradians of scan line skew.

Abstract: Instead of the usual glass case the heating element and thermostat of a submersible thermostatically controlled heater are disposed in separate cases made of metal and plastics respectively which are secured together in liquid-tight manner with the heating element connected through the thermostat to an external source of operating current and the metal case for the heating element connected to earth.

Abstract: An improved process for the conversion of gaseous uranium hexafluoride to a uranium oxide rich composition in the presence of an active flame in a reaction zone is achieved by introducing a first gaseous reactant comprising a mixture of uranium hexafluoride and an oxygen-containing carrier gas and a second gaseous reactant comprising a reducing gas, the reactants being separated by a shielding gas as introduced to the reaction zone. The shielding gas temporarily separates the gaseous reactants and temporarily prevents substantial mixing and reacting of the gaseous reactants. The flame occurring in the reaction zone is maintained away from contact with the inlet introducing the mixture to the reaction zone.

Abstract: A digital flow control system for testing ramjet engines that permits conl of fuel in steps, or percentages, of full flow rate. Four cavitating venturis connected to four valves control the flow rate through the valves such that the fuel flow rate is regulated in 10% increments of full flow rate depending upon the combination of valves which are open.

Abstract: This invention presents a process for conversion of gaseous uranium hexafluoride to an oxide product of uranium by introducing to a reaction zone in the presence of an active flame maintained in the reaction zone a first gaseous reactant comprising a mixture of uranium hexafluoride and an oxygen-containing gas and a second gaseous reactant comprising a reducing gas and temporarily separating the first and second gaseous reactants with a shielding gas which temporarily prevents substantial mixing and reaction between these gaseous reactants. The first and second gaseous reactants ultimately react in a primary flame to give a particulate uranium dioxide rich composition and residual reducing gas. An oxygen-containing gas as a third gaseous reactant is introduced through multiple downstream inlets with the inlet closest to the primary flame being at a location in the reaction zone where the uranium hexafluoride conversion to the uranium dioxide rich composition is substantially complete.