Abstract: The present invention relates to novel anti-PD1 and anti-LAG3 antibody molecules. The invention also relates to nucleic acids encoding such antibody molecules; to methods for preparing such antibody molecules; to host cells expressing or capable of expressing such antibody molecules; to compositions comprising such antibody molecules; and to uses of such antibody molecules or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: The technology disclosed relates to efficient tertiary analysis of genomic data. The technology disclosed includes splitting a genomic data file into a plurality of segments, and storing segments in the plurality of segments across nodes of a distributed storage system, pushing the segments from the nodes of the distributed storage system to nodes of a distributed, in-memory computing engine, distributing directives of tertiary analysis job contexts for the genomic data file across the nodes of the distributed, in-memory computing engine, directly executing the distributed directives on the segments stored on the nodes of the distributed, in-memory computing engine to cause parallel processing of the segments, and aggregating results of the parallel processing across the nodes of the distributed, in-memory computing engine to produce an output.

Abstract: A computer-implementation method includes receiving a data packet; identifying a virtual queue from a list of virtual queues to which the data packet pertains; and determining whether the identified virtual queue size exceeds a threshold maximum size. When the first size does not exceed the threshold maximum size, the identified virtual queue is increased based on a size of the data packet and the data packet is forwarded. The method further includes setting a virtual queue from the list of virtual queues as a target queue; determining a service capacity based on an update time interval and increasing a credit allowance based on the service capacity. The target queue is reduced by an amount based on the credit allowance size, and the credit allowance is reduced by the same amount.

Abstract: A system comprises a modem, configured to transmit data modulated based on an intermediate frequency within one of a C, X, or Ku band, and a single-stage block-up converter having an input electrically coupled via one inter-facility link cable to the modem, and an output electrically coupled to a high-power amplifier. The single-stage block-up-converter is configured to up-convert the intermediate frequency to a satellite communication frequency within the Ka, Q, or V band.

Abstract: A system comprises a modem, configured to transmit data modulated based on an intermediate frequency within one of a C, X, or Ku band, and a single-stage block-up converter having an input electrically coupled via one inter-facility link cable to the modem, and an output electrically coupled to a high-power amplifier. The single-stage block-up-converter is configured to up-convert the intermediate frequency to a satellite communication frequency within the Ka, Q, or V band.

Abstract: Methods and apparatuses for enhancing flatness of frequency response of couplings of radio frequency (RF) ports in an RF switch matrix. Techniques include determining a second RF port has been selected to be coupled to a first RF port via a coupling, obtaining an indication of a frequency or frequencies to be carried via the coupling, determining an amount of attenuation or amplification for the coupling for the frequency or frequencies, and adjusting attenuation or amplification applied to the coupling according to the determined amount attenuation or amplification.

Abstract: Methods and apparatuses for enhancing flatness of frequency response of couplings of radio frequency (RF) ports in an RF switch matrix. Techniques include determining a second RF port has been selected to be coupled to a first RF port via a coupling, obtaining an indication of a frequency or frequencies to be carried via the coupling, determining an amount of attenuation or amplification for the coupling for the frequency or frequencies, and adjusting attenuation or amplification applied to the coupling according to the determined amount attenuation or amplification.

Abstract: Soil conditioner compositions including manure-based organic fibers, pyrolytically processed into biochar. Also included are soil amendment compositions including growth factors such as nitrogen, phosphorus and potassium available for plants. Those growth factors may be obtained from the further processing of a liquid portion effluent resulting from heat-agitated anaerobic digestion of manure used to produce the fibers for the manure-based soil conditioner.

Abstract: An uplink power control system and a machine-implemented method for determining clear sky and adjusting uplink power are provided. A receiving station, which may be a satellite terminal or a satellite gateway, receives a reference signal from a satellite. The reference signal may be sampled over a sampling time period in order to compute a filtered short-term average downlink SINR. A filtered long-term average downlink SINR may be adjusted toward the filtered short-term average downlink SINR using either a first time constant or second time constant, based on a relationship between the filtered long-term average downlink SINR and the filtered short-term average downlink SINR. In some implementations, the second time constant is less than the first time constant.

Abstract: A method including determining that a first radio frequency (RF) port has been selected to be coupled via an M by N RF switch matrix to a second RF port, wherein the M by N radio frequency (RF) switch matrix includes M first-side RF ports and N second-side RF ports, the first RF port is included in the M first-side RF ports, the second RF port is included in the N second-side RF ports, M is at least 2 and N is at least 2, and each of the first-side RF ports may be selectively coupled to and uncoupled from at least one of two or more of the second-side RF ports, such that RF signals are carried between selectively coupled RF ports; obtaining a first indicator indicating a frequency, frequency range, channel, or band for an RF signal to be carried via the second RF port while coupled to the first RF port; obtaining, in response to the determination that the first RF port has been selected to be coupled to the second RF port, a first adjustment value based on the first indicator, the first RF port, and the secon

Abstract: A system, method, and computer program product are provided for adjusting vertex positions. One or more viewport dimensions are received and a snap spacing is determined based on the one or more viewport dimensions. The vertex positions are adjusted to a grid according to the snap spacing. The precision of the vertex adjustment may increase as at least one dimension of the viewport decreases. The precision of the vertex adjustment may decrease as at least one dimension of the viewport increases.

Abstract: A method including determining that a first radio frequency (RF) port has been selected to be coupled via an M by N RF switch matrix to a second RF port, wherein the M by N radio frequency (RF) switch matrix includes M first-side RF ports and N second-side RF ports, the first RF port is included in the M first-side RF ports, the second RF port is included in the N second-side RF ports, M is at least 2 and N is at least 2, and each of the first-side RF ports may be selectively coupled to and uncoupled from at least one of two or more of the second-side RF ports, such that RF signals are carried between selectively coupled RF ports; obtaining a first indicator indicating a frequency, frequency range, channel, or band for an RF signal to be carried via the second RF port while coupled to the first RF port; obtaining, in response to the determination that the first RF port has been selected to be coupled to the second RF port, a first adjustment value based on the first indicator, the first RF port, and the secon

Abstract: A system, method, and computer program product are provided for conservative rasterization of primitives using an error term. In use, an edge equation is determined for each edge of a primitive, the edge equation having coefficients defining the edge of the primitive. Each edge of the primitive is shifted to enlarge the primitive by modifying coefficients of the edge equation defining the edge by an error term that is a predetermined amount. Pixels that intersect the primitive are then determined using the enlarged primitive.

Abstract: A method and a satellite gateway for minimizing an impact of a noise floor variation in a spot beam satellite system. A demodulator processes digitized signals from multiple channels. Digitized signals are automatically gain controlled by respective automatic gain control components associated with respective channels. Automatic gain controlled digitized signals are downconverted and provided to a burst processor. The burst processor processes each downconverted signal and provides, with respect to each downconverted signal, an automatic gain control estimate, a code rate, and an inroute number to a processor component. The processor component determines an average automatic gain control value for each inroute, provides automatic gain control references to the respective automatic gain control components, and periodically sends noise map information to satellite terminals served by the satellite gateway. In some embodiments, the automatic gain control values are biased according to corresponding code rates.

Abstract: A method and a satellite terminal are provided. The satellite terminal may range over multiple frequencies and may receive, from a satellite gateway, a signal quality indicator with respect to each of the ranged multiple frequencies. Noise and interference for a corresponding frequency are estimated based on at least one of the received signal quality indicators for the corresponding frequency. Path loss is estimated based on multiple received signal quality indicators, each of which is received in response to the satellite terminal transmitting a signal while not performing the ranging process. A transmit power level of the satellite terminal is adjusted for the corresponding frequency based on the estimated path loss and the estimated noise and interference for the corresponding frequency.

Abstract: A system, method, and computer program product are provided for adjusting vertex positions. One or more viewport dimensions are received and a snap spacing is determined based on the one or more viewport dimensions. The vertex positions are adjusted to a grid according to the snap spacing. The precision of the vertex adjustment may increase as at least one dimension of the viewport decreases. The precision of the vertex adjustment may decrease as at least one dimension of the viewport increases.

Abstract: A system, method, and computer program product are provided for adjusting vertex positions. One or more viewport dimensions are received and a snap spacing is determined based on the one or more viewport dimensions. The vertex positions are adjusted to a grid according to the snap spacing. The precision of the vertex adjustment may increase as at least one dimension of the viewport decreases. The precision of the vertex adjustment may decrease as at least one dimension of the viewport increases.

Abstract: A method and a satellite terminal are provided. The satellite terminal may range over multiple frequencies and may receive, from a satellite gateway, a signal quality indicator with respect to each of the ranged multiple frequencies. Noise and interference for a corresponding frequency are estimated based on at least one of the received signal quality indicators for the corresponding frequency. Path loss is estimated based on multiple received signal quality indicators, each of which is received in response to the satellite terminal transmitting a signal while not performing the ranging process. A transmit power level of the satellite terminal is adjusted for the corresponding frequency based on the estimated path loss and the estimated noise and interference for the corresponding frequency.

Abstract: A plant nutrition composition including long organic fibers having nitrogen, phosphorus and potassium available for plants, in combination with organic substratum providing pH balancing in the range of about 6.0 to about 7.0. The long fibers may be the end product of slow, heat-agitated anaerobic digestion of manure. Combined with the fibers are substratum such as pine bark composted for a duration in the range of between about 9 months and about 12 months.

Abstract: This invention proposes a robotic applicator device to be deployed internally to a patient having a capsule (also referred to as a cassette) and aperture with a means of alternately occluding and exposing a radioactive source through the aperture. The capsule and aperture will be integrated with a surgical robot to create a robotic IORT (intra-operative radiation therapy) applicator device as more fully described below. The capsule, radiation source, and IORT applicator arm would be integrated to enable a physician, physicist or technician to interactively internally view and select tissue for exposure to ionizing radiation in sufficient quantities to deliver therapeutic radiation doses to tissue. Via the robotic manipulation device, the physician and physicist would remotely apply radiation to not only the tissue to be exposed, but also control the length of time of the exposure.