Abstract: The bottle safety seal may comprise a safety seal that covers the top of a bottle. The safety seal may prevent contaminants from collecting on exposed non-vertical surfaces of the bottle. As non-limiting examples, the contaminants may be from storing the bottle in a warehouse or other storage area where the bottle may be exposed to dust, dirt, spilled liquids, and other substances. The safety seal may be separable from the bottle such that the safety seal may be removed from the bottle prior to pouring or drinking from the bottle. As non-limiting examples, the bottle may be a water bottle, a wine bottle, a soda bottle, or a juice bottle. The bottle safety seal may be particularly suitable for use on 5 gallon water cooler bottles which may present larger exposed surface areas and may spend longer periods of time in storage before being used.