Patents by Inventor Walter Bottje

Walter Bottje has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods of enhancing immune responses to
    Patent number: 10842858
    Abstract: Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: November 24, 2020
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM, THE UNIVERSITY OF GUELPH
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Saeed El-Ashram, John Barta, Guillermo Tellez
  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA
    Publication number: 20180333474
    Abstract: Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
    Type: Application
    Filed: July 6, 2018
    Publication date: November 22, 2018
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Saeed El-Ashram, John Barta, Guillermo Tellez
  • Compositions and methods of enhancing immune responses to Eimeria
    Patent number: 10016493
    Abstract: Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: July 10, 2018
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Saeed El-Ashram, John Barta, Guillermo Tellez
  • Compositions and methods of enhancing immune responses
    Patent number: 10004798
    Abstract: Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: June 26, 2018
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton
  • Vaccine vectors and methods of enhancing immune responses
    Patent number: 9913893
    Abstract: Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: March 13, 2018
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Luc Berghman, Walter Bottje, Billy Hargis, Sherryll Layton
  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES
    Publication number: 20160114025
    Abstract: Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
    Type: Application
    Filed: December 16, 2015
    Publication date: April 28, 2016
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton
  • Compositions and methods of enhancing immune responses
    Patent number: 9226957
    Abstract: Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: January 5, 2016
    Assignees: The Texas A&M University System, The Board of Trustees of the University of Arkansas
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton
  • Compositions and methods of enhancing immune responses to flagellated bacterium
    Patent number: 9125854
    Abstract: Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: September 8, 2015
    Assignees: The Board of Trustees of the University of Arkansas, The Texas A&M University System
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Sherryll Layton
  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA
    Publication number: 20150216954
    Abstract: Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
    Type: Application
    Filed: February 16, 2015
    Publication date: August 6, 2015
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM, THE UNIVERSITY OF GUELPH
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Said El-Ashram, John Barta, Guillermo Tellez
  • VACCINE VECTORS AND METHODS OF ENHANCING IMMUNE RESPONSES
    Publication number: 20150190500
    Abstract: Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
    Type: Application
    Filed: February 16, 2015
    Publication date: July 9, 2015
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Luc Berghman, Walter Bottje, Billy Hargis, Sherryll Layton
  • Vaccine vectors and methods of enhancing immune responses
    Patent number: 8956618
    Abstract: Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: February 17, 2015
    Assignees: The Texas A&M University System, The Board of Trustees of the University of Arkansas
    Inventors: Luc Berghman, Walter Bottje, Billy Hargis, Sherryll Layton
  • Compositions and methods of enhancing immune responses to
    Patent number: 8956849
    Abstract: Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: February 17, 2015
    Assignees: The Board of Trustees of the University of Arkansas, The Texas A&M University System, The University of Guelph
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Said El-Ashram, John Barta, Guillermo Tellez
  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES
    Publication number: 20140093534
    Abstract: Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
    Type: Application
    Filed: December 9, 2013
    Publication date: April 3, 2014
    Applicants: THE TEXAS A&M UNIVERSITY SYSTEM, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton
  • Compositions and methods of enhancing immune responses
    Patent number: 8604178
    Abstract: Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: December 10, 2013
    Assignees: The Board of Trustees of the University of Arkansas, The Texas A&M University of System
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton
  • COMPOSITIONS AND METHODS FOR INCREASING POULTRY HATCHABILITY AND EARLY PERFORMANCE
    Publication number: 20130116174
    Abstract: Compositions and methods of improving poultry hatch health are provided herein. Poultry hatch health and hatchability may be improved by administering compositions in ovo prior to hatch. The compositions include iodinated tyrosine-containing proteins, suitably iodinated casein, and carbohydrates.
    Type: Application
    Filed: July 11, 2011
    Publication date: May 9, 2013
    Applicant: The Board of Trustees of the University of Arkansas
    Inventors: Billy Hargis, Walter Bottje
  • VACCINE VECTORS AND METHODS OF ENHANCING IMMUNE RESPONSES
    Publication number: 20120282291
    Abstract: Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
    Type: Application
    Filed: January 21, 2011
    Publication date: November 8, 2012
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Luc Berghman, Walter Bottje, Billy Hargis, Sherryll Layton
  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO FLAGELLATED BACTERIUM
    Publication number: 20110159026
    Abstract: Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
    Type: Application
    Filed: October 30, 2008
    Publication date: June 30, 2011
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSA
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton
  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA
    Publication number: 20110111015
    Abstract: Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD4Q. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
    Type: Application
    Filed: November 3, 2008
    Publication date: May 12, 2011
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Said El-Ashram, John Barta, Guillermo Tellez
  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES
    Publication number: 20110027309
    Abstract: Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
    Type: Application
    Filed: September 18, 2007
    Publication date: February 3, 2011
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton
  • METHODS AND SYSTEMS FOR DETECTION OF CONTAMINANTS
    Publication number: 20100120016
    Abstract: An impedance biosensor for detecting a contaminant in a starting material, the biosensor comprising a housing, an input device supported by the housing, an output device supported by the housing, a microfluidic cell supported by the housing, the starting material being engagable with the microfluidic cell, and an impedance analyzer supported by the housing and operable to measure impedance of the starting material to detect the presence of a contaminant.
    Type: Application
    Filed: August 31, 2007
    Publication date: May 13, 2010
    Inventors: Yanbin Li, Billy Hargis, Steve Tung, Luc Berghman, Walter Bottje, Ronghui Wang, Zunzhong Ye, Madhukar Varshney, Balaji Srinivasan