Patents by Inventor Walter Boudewijn Leopold Wouters

Walter Boudewijn Leopold Wouters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6-ALKENYL AND 6-PHENYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS
    Publication number: 20110124673
    Abstract: The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors wherein n, R1, R2, R3, R4, R5, R6, R7, Re, Rd and X have defined meanings.
    Type: Application
    Filed: November 19, 2010
    Publication date: May 26, 2011
    Inventors: Dominique Jean-Pierre Mabire, Jerôme Emile Georges Guillemont, Jacobus Alphonsus Josephus Van Dun, Maria Victorina Francisca Somers, Walter Boudewijn Leopold Wouters
  • 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
    Patent number: 7928104
    Abstract: The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, R1, R2, R3, R4, R5, R6 and X have defined meanings.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: April 19, 2011
    Inventors: Dominique Jean-Pierre Mabire, Jérôme Emile Georges Guillemont, Jacobus Alphonsus Josephus Van Dun, Maria Victorina Francisca Somers, Walter Boudewijn Leopold Wouters
  • SUBSTITUTED 2-ALKYL QUINAZOLINONE DERIVATIVES AS PARP INHIBITORS
    Publication number: 20110077245
    Abstract: The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R3, L, X, Y and Z have defined meanings.
    Type: Application
    Filed: December 3, 2010
    Publication date: March 31, 2011
    Inventors: Marcel Jozef Maria Van der Aa, Albertus Henricus Maria Theresia Van Heertum, Jacobus Alphonsus Josephus van Dun, Maria Victorina Francisca Somers, Walter Boudewijn Leopold Wouters
  • 6-substituted 2-quinolinones and 2-quinoxalinones as poly (adp-ribose) polymerase inhibitors
    Patent number: 7879857
    Abstract: The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, R1, R2, R3, R4 and X have defined meanings.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: February 1, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Dominique Jean-Pierre Mabire, Jérôme Emile Georges Guillemont, Jacobus Alphonsus Josephus Van Dun, Maria Victorina Francisca Somers, Walter Boudewijn Leopold Wouters
  • 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adpribose) polymerase inhibitors
    Patent number: 7855207
    Abstract: The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors wherein n, R1, R2, R3, R4, R5, R6, R7, Re, Rd and X have defined meanings.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: December 21, 2010
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Dominique Jean-Pierre Mabire, Jér{hacek over (o)}me Emile Georges Guillemont, Jacobus Alphonsus Josephus Van Dun, Maria Victorina Francisca Somers, Walter Boudewijn Leopold Wouters
  • species that produces a bafilomycin-like metabolite
    Patent number: 7803600
    Abstract: The invention provides a compound of formula (I) and pharmaceutically acceptable salts thereof. Processes for the isolating of this bafilomycin metabolite from a novel Micromonospora species, pharmaceutical compositions containing this metabolite and methods of treatment using said metabolite are also described.
    Type: Grant
    Filed: March 12, 2007
    Date of Patent: September 28, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jacobus Alphonsus Josephus Van Dun, Walter Boudewijn Leopold Wouters, Michel Marie François Janicot, Ursula Maria Mocek, Jodi Ann Laakso
  • Phthalazine derivatives as parp inhibitors
    Patent number: 7803795
    Abstract: The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2 L1, L2, X, Y, Q and Z have defined meanings.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: September 28, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Laurence Anne Mevellec, Ludo Edmond Josephine Kennis, Josephus Carolus Mertens, Jacobus Alphonsus Josephus Van Dun, Maria Victorina Francisca Somers, Walter Boudewijn Leopold Wouters
  • Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
    Patent number: 7652014
    Abstract: The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, s, R1, R2, R3, Q, X and Y have defined meanings.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: January 26, 2010
    Assignee: Janssen Pharmaceutica
    Inventors: Dominique Jean-Pierre Mabire, Jacobus Alphonsus Josephus Van Dun, Maria Victorina Francisca Somers, Walter Boudewijn Leopold Wouters
  • SUBSTITUTED 6-CYCLOHEXYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS
    Publication number: 20090042881
    Abstract: The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, s, R1, R2, R3, Q, X and Y have defined meanings.
    Type: Application
    Filed: November 18, 2004
    Publication date: February 12, 2009
    Inventors: Dominique Jean-Pierre Mabire, Jacobus Alphonsus Josephus Van Dun, Maria Victorina Francisca Somers, Walter Boudewijn Leopold Wouters
  • 7-Phenylalkyl Substituted 2-Quinolinones and 2-Quinoxalinones as Poly(Adp-Ribose) Polymerase Inhibitors
    Publication number: 20080249099
    Abstract: The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, R1, R2, R3, R4, R5, R6 and X have defined meanings.
    Type: Application
    Filed: November 18, 2004
    Publication date: October 9, 2008
    Applicant: JANSSEN PHARMACEUTICA N.V.
    Inventors: Dominique Jean-Pierre Mabire, Jerome Emile Georges Guillemont, Jacobus Alphonsus Josephus Van Dun, Maria Victorina Francisca Somers, Walter Boudewijn Leopold Wouters
  • Substituted 2-Alkyl Quinazolinone Derivatives as Parp Inhibitors
    Publication number: 20080176876
    Abstract: The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R3, L, X, Y and Z have defined meanings.
    Type: Application
    Filed: June 28, 2005
    Publication date: July 24, 2008
    Inventors: Marcel Josef Maria Van Der AA, Albertus Henricus Maria Van Heertum, Jacobus Alphonsus Josephus Van Dun, Maria Victorina Francisca Somers, Walter Boudewijn Leopold Wouters
  • Phthalazine Derivatives as Parp Inhibitors
    Publication number: 20080139568
    Abstract: The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2 L1, L2, X, Y, Q and Z have defined meanings.
    Type: Application
    Filed: June 28, 2005
    Publication date: June 12, 2008
    Inventors: Laurence Anne Mevellec, Ludo Edmond Josephine Kennis, Josephus Carolus Mertens, Jacobus Alphonsus Josephus Van Dun, Maria Victorina Francisca Somers, Walter Boudewijn Leopold Wouters
  • Quinazoline Derivatives as Parp Inhibitors
    Publication number: 20080070915
    Abstract: The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compnounds of formula (I) wherein R1, R2, R3, L, X, Y and Z have defined meanings.
    Type: Application
    Filed: June 28, 2005
    Publication date: March 20, 2008
    Inventors: Jerome Emile Georges Guillemont, Ludo Edmond Josephine Kennis, Josephus Carolus Mertens, Jacobus Alphonsus Josephus Van Dun, Maria Victorina Francisca Somers, Walter Boudewijn Leopold Wouters
  • Bafilomycin-like metabolite from a novel species
    Patent number: 7214705
    Abstract: The invention provides a compound of formula (I) and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: May 8, 2007
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jacobus Alphonsus Josephus Van Dun, Walter Boudewijn Leopold Wouters, Michel Marie François Janicot, Ursula Maria Mocek, Jodi Ann Laakso
  • Combination of a RAMBA and a tocopherol
    Patent number: 6265425
    Abstract: The present invention is concerned with the use of a tocopherol for the manufacture of a medicament for avoiding, alleviating, suppressing or overcoming the adverse side-effects of therapy with a retinoic acid metabolism blocking agent. The present invention is also concerned with the combination of 4-(heteroaryl-methyl)anilines with vitamin E and its use as a medicine.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: July 24, 2001
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Peter Marie-Zoë Robert De Porre, Jan Paul Jozef Michel Bruynseels, Walter Boudewijn Leopold Wouters