Patents by Inventor Walter C. Herlihy
Walter C. Herlihy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5795860Abstract: Disclosed are (1) methods for identifying natural and synthetic sequences having binding specificity for glycan-binding proteins, including proteins that act as effectors of biological activity, (2) compositions and methods of producing protein-specific glycosaminoglycan sequence and ligand antagonists capable of modulating the effector function of these ligands, and therapeutic compositions comprising these antagonists; and 3) compositions and methods for producing protein-specific glycosaminoglycan sequence analogs useful as agonists, and therapeutic compositions comprising these agonists.Type: GrantFiled: February 28, 1994Date of Patent: August 18, 1998Assignee: Repligen CorporationInventors: Daniel P. Witt, Walter C. Herlihy, Jr.
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Patent number: 5260373Abstract: The invention concerns unique immobilized immunoglobulin-binding protein materials which have a high binding capacity for immunoglobulins. Exemplified are preparations which have a high binding capacity for IgGl immunoglobulins. The preparations are made by covalently joining an immobilization support material to (a) an arginine-containing linker and (b) an immunoglobulin-binding protein material. The immunoglobulin-binding protein can be joined to the linker through an amide bond. Specifically disclosed is an immobilized protein A preparation. This immobilized protein A preparation has utility in the art of purifying monoclonal antibodies.Type: GrantFiled: February 18, 1992Date of Patent: November 9, 1993Assignee: Repligen CorporationInventors: Albert T. Profy, Margaret A. Belew, Walter C. Herlihy
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Patent number: 5089605Abstract: The invention concerns unique immobilized immunoglobulin-binding protein materials which have a high binding capacity for immunoglobulins. Exemplified are preparations which have a high binding capacity for IgGl immunoglobulins. The preparations are made by covalently joining an immobilization support material to (a) an arginine-containing linker and (b) an immunoglobulin-binding protein material. The immunoglobulin-binding protein can be joined to the linker through an amide bond. Specifically disclosed is an immobilized protein A preparation. This immobilized protein A preparation has utility in the art of purifying monoclonal antibodies.Type: GrantFiled: March 13, 1987Date of Patent: February 18, 1992Assignee: Repligen CorporationInventors: Albert T. Profy, Margaret A. Belew, Walter C. Herlihy
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Patent number: 4776857Abstract: The invention concerns a new system to dye hair and/or skin. The system comprises the use of a hydroxyindole dye precursor and sodium periodate. Advantageously, this dye system allows the dye to penetrate inside the hair fiber without coating the hair shaft and, thus, give a more pleasing and stable dye result.Type: GrantFiled: November 21, 1986Date of Patent: October 11, 1988Assignee: Repligen CorporationInventors: James Carroll, Cynthia D. Millis, Walter C. Herlihy
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Patent number: 4746322Abstract: The subject invention concerns novel dye compositions and a process for dyeing keratinous fibers, for example, hair, to give a pleasing and stable colored product. The dye composition is a novel combination of three elements to give a dye that, unexpectedly, has highly desirable dyeing properties. This unique combination comprises (1) a suitable organic compound to assist dye dispersion, (2) dye precursors including dopamine, D-dopa, L-dopa, D,L-dopa, or analogs thereof, and (3) iodate or periodate. Desired color variations can be obtained by the use of appropriate color modifiers.Type: GrantFiled: May 11, 1987Date of Patent: May 24, 1988Assignee: Repligen CorporationInventor: Walter C. Herlihy
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Patent number: 4629792Abstract: An in vitro enzymatic process which efficiently converts (+,-)-tropicamide to essentially pure (+), (-)-tropicamide O-.beta.-D-glucuronide. This product is then separated, advantageously, into the novel compounds (+)-tropicamide O-.beta.-D-glucuronide and (-)-tropicamide O-.beta.-D-glucuronide. The products disclosed herein absorb ultraviolet light, and, thus, can be incorporated into suitable plastic films which are then useful for screening out harmful ultraviolet radiation for the protection of packaged goods. Also, the products can be used to protect the skin against burning by sunlight.Type: GrantFiled: September 9, 1985Date of Patent: December 16, 1986Assignee: Repligen CorporationInventors: Walter C. Herlihy, Thomas H. Fraser
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Patent number: 4609544Abstract: The subject invention concerns a novel, unobvious, and useful composition of matter and method for tanning the human epidermis. The composition comprises a suitable dye precursor, peroxidase and H.sub.2 O.sub.2. These ingredients, when reacted together on the skin, result in the formation of melanin-like dyes which tan the skin.Type: GrantFiled: July 5, 1983Date of Patent: September 2, 1986Assignee: Repligen CorporationInventor: Walter C. Herlihy
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Patent number: 4588686Abstract: An in vitro enzymatic process which efficiently converts (+,-)-tropicamide to essentially pure (+), (-)-tropicamide O-.beta.-D-glucuronide. This product is then separated, advantageously, into the novel compounds (+)-tropicamide O-.beta.-D-glucuronide and (-)-tropicamide O-.beta.-D-glucuronide. The products disclosed herein absorb ultraviolet light, and, thus, can be incorporated into suitable plastic films which are then useful for screening out harmful ultraviolet radiation for the protection of packaged goods. Also, the products can be used to protect the skin against burning by sunlight.Type: GrantFiled: January 31, 1984Date of Patent: May 13, 1986Assignee: Repligen CorporationInventors: Walter C. Herlihy, Thomas H. Fraser
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Patent number: 4546096Abstract: This invention concerns novel and useful human antiperspirant compounds which are glucuronides of phenolic anticholinergics or the phenolic derivatives of anticholinergic compounds. These antiperspirant compounds, advantageously, do not have mydriatic properties possessed by the parent anticholinergic compounds.Type: GrantFiled: February 24, 1984Date of Patent: October 8, 1985Assignees: Repligen Corporation, The Gillette CompanyInventors: Walter C. Herlihy, David M. Epstein, Carl B. Felger
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Patent number: 4518691Abstract: An in vitro enzymatic process which efficiently converts ester-containing anticholinergics having a primary alcohol to their corresponding novel O-glucuronic acid derivatives. These novel glucuronides are useful as antiperspirants.Type: GrantFiled: May 4, 1984Date of Patent: May 21, 1985Assignee: Repligen CorporationInventor: Walter C. Herlihy
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Patent number: 4515773Abstract: The subject invention concerns a novel, unobvious, and useful composition of matter and method for tanning the human epidermis. The composition comprises a suitable dye precursor and tyrosinase. These ingredients, when reacted together on the skin, result in the formation of melanin-like dyes which tan the skin.Type: GrantFiled: July 5, 1983Date of Patent: May 7, 1985Assignee: Repligen CorporationInventor: Walter C. Herlihy
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Patent number: 4478936Abstract: An in vitro enzymatic process for preparing O-.beta.-D-glucuronides which comprises reacting a solution of D-glucuronic acid with a solution of a compound which has a primary alcohol, and a solution of .beta.-glucuronidase for a time sufficient to form the desired glucuronide. The glucuronides can be used for the following purposes: antiperspirants, cardiotonic agents, gastric acid inhibitors, vitamin D derivatives, treatment of psoriasis, and as antitumor agents.Type: GrantFiled: August 20, 1982Date of Patent: October 23, 1984Assignee: Repligen CorporationInventor: Walter C. Herlihy
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Patent number: 4476300Abstract: The subject invention concerns a novel process for preparing novel N-oxide compounds of O-.beta.-D-glucuronides of an anticholinergic compound containing a tertiary nitrogen. Examples of suitable glucuronide starting materials are O-.beta.-D-glucuronides of tropicamide, scopolamine, atropine, hyoscyamine, and the like. The novel process gives high yields of the desired N-oxides which are useful as UV filters.Type: GrantFiled: August 4, 1983Date of Patent: October 9, 1984Assignee: Repligen CorporationInventors: Walter C. Herlihy, David M. Epstein
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Patent number: 4471111Abstract: An in vitro enzymatic process which efficiently converts ester-containing anticholinergics having a primary alcohol to their corresponding novel O-glucuronic acid derivatives. These novel glucuronides are useful as antiperspirants.Type: GrantFiled: July 14, 1982Date of Patent: September 11, 1984Assignee: Repligen CorporationInventor: Walter C. Herlihy
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Patent number: 4443608Abstract: An in vitro enzymatic process which efficiently converts (+,-)-tropicamide to essentially pure (+), (-)-tropicamide O-.beta.-D-glucuronide. This product is then separated, advantageously, into the novel compounds (+)-tropicamide O-.beta.-D-glucuronide and (-)-tropicamide O-.beta.-D-glucuronide. The products disclosed herein absorb ultraviolet light, and, thus, can be incorporated into suitable plastic films which are then useful for screening out harmful ultraviolet radiation for the protection of packaged goods. Also the products can be used to protect the skin against burning by sunlight.Type: GrantFiled: May 24, 1982Date of Patent: April 17, 1984Assignee: Repligen CorporationInventors: Walter C. Herlihy, Thomas H. Fraser