Patents by Inventor Walter Cabri

Walter Cabri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLINE FORM II OF 7-(DIMETHOXY-METHYL) CAMPTOTHECIN, ITS USE AS INTERMEDIATE AND PRODUCTS OBTAINED THEREFROM
    Publication number: 20100249414
    Abstract: This invention relates to a process for preparing a crystalline form of (4S)-11-(dimethoxymethyl)-4-ethyl-4-hydroxy-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]qui-noline-3,14(4H,12H)-dione (also named 7-(dimethoxy-methyl)camptothecin). With the provision of a particular crystallization step, in appropriate way, a new crystalline form of the above compound is obtained. The process for the preparation of the polymorph Form II comprises transforming camptothecin to the corresponding 7-(dimethoxy-methyl)-camptothecin, and crystallizing it from methanol.
    Type: Application
    Filed: July 22, 2008
    Publication date: September 30, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Walter Cabri, Mauro Marzi, Fabrizio Giorgi, Elena Badaloni, Silvia Armaroli, Giuseppe Marazzi
  • Stereoselective process and crystalline forms of a camptothecin
    Patent number: 7799921
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: September 21, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • Method of producing lycopene through the fermentation of selected strains of , formulations and uses of the lycopene thus obtained
    Patent number: 7799540
    Abstract: The method of fermentation with selected strains of B. trispora described in the present invention makes it possible to achieve lycopene yields higher than those currently described. The methods of isolation, purification and formulation are applicable to any natural source of lycopene, especially to submerged cultures of mucoral fungi of the genera Blakeslea, Choanephora, Phycomyces or Mucor. The method of extraction makes it possible to simplify the recovery process and increase the purity of the product, relative to the methods previously described. The methods of formulation provide high added value, since they make it possible to obtain stabilized preparations of lycopene for direct application in the food and pharmaceutical fields.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: September 21, 2010
    Assignee: Vitatene, S.A.
    Inventors: Ana Teresa Marcos Rodríguez, Antonio Estrella De Castro, Javier Costa Perez, Manuel Antonio Oliver Ruiz, Nieves Fraile Yecora, Juan Luis De La Fuente Moreno, Marta Rodríguez Saiz, Bruno Diez Garcia, Enrieque Peiro Cezon, Angel Muñoz Ruiz, Walter Cabri, Juan Francisco Lopez Ortiz, José Luis Barredo Fuente
  • AMIDE COMPOUNDS AND THEIR USE AS ANTITUMOR AGENTS
    Publication number: 20100113504
    Abstract: The present invention relates to a compound of Formula (I), its geometrical isomers, in an optically active form as enantiomers, diastereomers, as well as in the form of racemate, as well as pharmaceutically acceptable salts thereof, wherein R is selected from CONHOH, CONHCH2SH, CONHCH2SCOCH3, SH, SCOCH3, SCH3, N(OH)COH, COCONHCH3 and CF3 for the preparation of a medicament, in particular for selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells, for inducing differentiation of tumor cells in a tumor, for inhibiting the activity of histone deacetylase and for the treatment of primary cancer or secondary cancer.
    Type: Application
    Filed: March 12, 2008
    Publication date: May 6, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Stephan Hanessian, Luciana Auzzas, Giuseppe Giannini, Claudio Pisano, Loredana Vesci, Walter Cabri
  • STEREOSELECTIVE PROCESS AND CRYSTALLINE FORMS OF A CAMPTOTHECIN
    Publication number: 20090239893
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Application
    Filed: December 16, 2005
    Publication date: September 24, 2009
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • INTERMEDIATE CEFDINIR SALTS
    Publication number: 20090036672
    Abstract: Disclosed are salts of the general formula (I) wherein R1, R2 and B are as defined in the description and methods for the preparation thereof. These salts are useful intermediates for the preparation of cefdinir.
    Type: Application
    Filed: July 29, 2008
    Publication date: February 5, 2009
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Giovanni Pozzi, Patricio Martin Gomez, Marco Alpegiani, Walter Cabri
  • Intermediate cefdinir salts
    Patent number: 7405294
    Abstract: Disclosed are salts of the general formula (I) wherein R1, R2 and B are defined in the description. These salts are useful intermediates for the preparation of cefdinir. Also, disclosed are processes for the preparation thereof from the compounds of the general formula (II) and (III). Further, disclosed is a method of producing cefdinir from the salts of the general formula (I) including the steps of removing protecting groups.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: July 29, 2008
    Assignee: Antibioticos S.p.A.
    Inventors: Giovanni Pozzi, Patricio Martin Gomez, Marco Alpegiani, Walter Cabri
  • Cephalosporin C acylases
    Patent number: 7399624
    Abstract: Enzymes with cephalosporin C acylase activity obtained by site-directed, random or “site-saturation” mutagenesis of a native sequence optimised for expression in E. coli.
    Type: Grant
    Filed: January 11, 2005
    Date of Patent: July 15, 2008
    Assignee: Antibioticos S.p.A.
    Inventors: Loredano Pollegioni, Mirella Pilone, Gianluca Molla, Eugenio Cucchetti, Roberto Verga, Walter Cabri
  • Process for the Purification of Tacrolimus
    Publication number: 20080160586
    Abstract: A process for the purification and recovery of Tacrolimus (I) (17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methyvinyl]-23,25- dimethoxy-13,19,21,27-tetramethyl-11,28-dioxi-4-azatricyclo-[22.3.1.04.9]octacos-18-en-2,3,10,16-tetraone), starting from Streptomyces sp fermentation broth. The process is particularly advantageous in terms of productivity and selectivity of the separation of impurities.
    Type: Application
    Filed: October 24, 2005
    Publication date: July 3, 2008
    Applicant: Antibioticos S.p.A.
    Inventors: Walter Cabri, Paolo Paissoni, Jacopo Roletto, Luca Morra
  • Purification of Tacrolimus on Supports of Vegetable Origin
    Publication number: 20080161555
    Abstract: The invention relates to a process for the purification of tacrolimus comprising contacting crude tacrolimus with a silver salt dissolved in a water/organic solvent mixture and with a carrier of vegetable origin, separating the mixture from the carrier and recovering purified tacrolimus.
    Type: Application
    Filed: July 10, 2006
    Publication date: July 3, 2008
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Luca Morra, Jacopo Roletto, Giovanni Lazzari, Walter Cabri, Paolo Paissoni
  • Epoxidation of 17-oxo-15,16-Methylene Steroids with Sulfoxonium Ylides
    Publication number: 20080076915
    Abstract: A process for the epoxidation of 17-oxo-15,16-methylene steroids, in particular of drospirenone precursors, comprising the use of sulfoxonium ylides, in particular of dimethylsulfoxonium methyl ylide. The process allows to prepare in good yields 17-spiro epoxides, which can be easily transformed into 17-spironolacto-steroids.
    Type: Application
    Filed: September 21, 2007
    Publication date: March 27, 2008
    Applicant: ANTIBIOTICOS S.P.A.
    Inventors: Walter Cabri, Fabio Benedetti, Marco Alpegiani, Manuela Rodriquez, Cinzia Bottai
  • Crystalline Form Of Cefdinir Ammonium Salt As An Intermediate For The Preparation Of Pure Cefdinir
    Publication number: 20080033169
    Abstract: The invention relates to crystalline Cefdinir ammonium salt of formula (I) and to a process for the preparation thereof. This salt is particularly advantageous in that it allows to prepare highly pure Cefdinir.
    Type: Application
    Filed: October 24, 2005
    Publication date: February 7, 2008
    Inventors: Giovanni Pozzi, Paolo Ghetti, Gaetano Balsamo, Marco Alpegiani, Walter Cabri
  • Method of production of ?-carotene by fermentation in mixed culture using (+) and (?) strains of
    Patent number: 7252965
    Abstract: The invention consists of fermenting selected strains of Blakeslea trispora in conditions such that ?-carotene is produced in the form of stabilized preparations with residual contents of other carotenoids (?-carotene and ?-zeacarotene). The fermentation conditions chosen include the programmed addition of oxygen and/or ?-ionone during fermentation, and control of the age of the vegetative growth phases of the strains employed. The ?-carotene obtained can be used in the pharmaceutical and food sectors.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: August 7, 2007
    Assignee: Antibioticos, S.A.U.
    Inventors: Javier Costa Perez, Ana Teresa Marcos Rodríguez, Juan Luis De La Fuente Moreno, Marta Rodríguez Saiz, Bruno Diez Garcia, Enrique Peiro Cezon, Walter Cabri, José Luis Barredo Fuente
  • Crystalline cefdinir salts
    Patent number: 7173126
    Abstract: Cefdinir crystalline salts of formula (I), in which n ranges from 1 to 3, the preparation and use thereof for the preparation and purification of cefdinir are herein disclosed. The salts of formula (I) can be obtained from cefdinir intermediates or crude cefdinir by treatment with phosphoric acid.
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: February 6, 2007
    Assignee: Antibioticos S.p.A.
    Inventors: Giovanni Pozzi, Patricio Martin Gomez, Marco Alpegiani, Walter Cabri
  • Intermediate cefdinir salts
    Publication number: 20060111566
    Abstract: Disclosed are salts of the general formula (I) wherein R1, R2 and as defined in the description and a process for the preparation thereof. These salts are useful intermediates for the preparation of cefdinir.
    Type: Application
    Filed: September 26, 2003
    Publication date: May 25, 2006
    Applicant: Antibioticos S.p.A.
    Inventors: Giovanni Pozzi, Patricio Martinez Gomez, Marco Alpegiani, Walter Cabri
  • Method for obtaining novel lutein-based formulations
    Patent number: 7045643
    Abstract: The present invention describes a method of preparation of formulations of microcrystalline lutein, particularly in the form of esters, which are resistant to oxidation and are soluble in hydrophilic and/or lipophilic media. For these formulations, the esters of lutein are mixed with antioxidants, vegetable oils and/or organic solvents, and this initial mixture is submitted to various stages depending on the type of final formulation required. These formulations are suitable for direct application as colourants in the pharmaceutical, food and cosmetics fields. They can also be used as diet supplements.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: May 16, 2006
    Assignee: Vitatene, S.A.
    Inventors: Antonio Estrella De Castro, Nieves Fraile Yecora, Manuel Oliver Ruiz, Angel Muñoz, Juan Francisco Lopez Oritz, Walter Cabri
  • Crystalline cefdinir salts
    Publication number: 20060074236
    Abstract: Cefdinir crystalline salts of formula (I), in which n ranges from 1 to 3, the preparation and use thereof for the preparation and purification of cefdinir is herein disclosed. The salts of formula (I) can be obtained from cefdinir intermediates or crude cefdinir by treatement with phosphoric acid.
    Type: Application
    Filed: December 1, 2003
    Publication date: April 6, 2006
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Giovanni Pozzi, Patricio Martin Gomez, Marco Alpegiani, Walter Cabri
  • Process for the synthesis of pergolide
    Patent number: 7019140
    Abstract: A process for the synthesis of pergolide (Formula (I)) (D-6-n-propyl-8?methylmercaptomethylergo line) from acid 9,10-dihydrolysergic is herein disclosed. The process can be carried out without isolating most intermediates and is particularly convenient both from the yield and safety standpoint.
    Type: Grant
    Filed: March 10, 2003
    Date of Patent: March 28, 2006
    Assignee: Antibioticos S.p.A.
    Inventors: Walter Cabri, Paolo Paissoni, Jacopo Roletto, Piera Fonte, Sara Olmo
  • Process for the synthesis of thalidomide
    Publication number: 20050272934
    Abstract: The invention relates to a process for the preparation of thalidomide (I) comprising the reaction between glutamine (II) and a phthaloylating agent, preferably phthalic anhydride, to give N-phthaloyl-glutamine, which is directly transformed in thalidomide.
    Type: Application
    Filed: May 31, 2005
    Publication date: December 8, 2005
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Marco Alpegiani, Andrea Mazzoni, Domenico Vergani, Walter Cabri
  • Cephalosporin C acylases
    Publication number: 20050158818
    Abstract: Enzymes with cephalosporin C acylase activity obtained by site-directed, random or “site-saturation” mutagenesis of a native sequence optimised for expression in E. coli.
    Type: Application
    Filed: January 11, 2005
    Publication date: July 21, 2005
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Loredano Pollegioni, Mirella Pilone, Gianluca Molla, Eugenio Cucchetti, Roberto Verga, Walter Cabri