Abstract: Provided herein are anti-Ly6G6D (lymphocyte antigen 6 complex, locus G61) antibodies and methods of using the same.

Abstract: Provided herein are anti-Ly6G6D (lymphocyte antigen 6 complex, locus G61) antibodies and methods of using the same.

Abstract: A semantic multilayer network is established, wherein a first layer in said semantic multilayer network including tag annotations, and a second layer in said semantic multilayer network including data structured by an ontology, are established and wherein the first layer and the second layer are connected. Thus, connecting of two entirely different worlds of the dynamic, emergent “social tagging” (e.g., web applications like Web 2.0) and of the regular “ontology engineering” (e.g. Semantic Web) data, dynamic data tag annotations and ontology, seen as too opposed or conflictive, therefore being treated separately and independently so far, becomes possible. Here, by utilizing advantages of both worlds, computer aided handling of large amounts of data, including e.g. processing, management, or querying of data, becomes considerably efficient and effective, wherein said data may be distributed in different areas, locations, or systems.

Abstract: Solid compositions of low-solubility drugs and poloxamers that provide concentration enhancement when administered to an aqueous environment of use are disclosed.

Abstract: Pharmaceutical compositions of a low-solubility drug and lower alkanoate-, phthalate- and trimellitate esters of hydroxypropyl methyl cellulose and lower alkanoate- and succinate esters of cellulose and methyl cellulose are disclosed that provide enhanced concentrations of the drug in a use environment.

Abstract: A method for calculating at least one relationship metric of a relationship between objects has the steps of providing a multi-layered relationship network with a first relationship layer derived from potential relations between objects, a second relationship layer derived from interactions between objects, a third relationship layer derived from explicit relations between objects, and an aggregated relationship layer derived from at least two layers of the relationship layers, and wherein each layer has a graph with one vertex for every object represented in the network and at least one unidirectional and/or bidirectional edge between at least two of the objects, and calculating the edge weights based on the edge weights of at least two relationship layers, selecting at least the relationship with a highest edge weight between an object and other objects, and finally outputting the weights of the selected relationships as the calculated relationship metrics.

Abstract: A method for calculating at least one relationship metric of a relationship between objects has the steps of providing a multi-layered relationship network with a first relationship layer derived from potential relations between objects, a second relationship layer derived from interactions between objects, a third relationship layer derived from explicit relations between objects, and an aggregated relationship layer derived from at least two layers of the relationship layers, and wherein each layer has a graph with one vertex for every object represented in the network and at least one unidirectional and/or bidirectional edge between at least two of the objects, and calculating the edge weights based on the edge weights of at least two relationship layers, selecting at least the relationship with a highest edge weight between an object and other objects, and finally outputting the weights of the selected relationships as the calculated relationship metrics.

Abstract: The quantization parameter QP is well-known in digital video compression as an indication of picture quality. Digital symbols representing a moving image are quantized with a quantizing step that is a function QSN of the quantization parameter QP, which function QSN has been normalized to the most significant bit of the bit depth of the digital symbols. As a result, the effect of a given QP is essentially independent of bit depth a particular QP value has a standard effect on image quality, regardless of bit depth. The invention is useful, for example, in encoding and decoding at different bit depths, to generate compatible, bitstreams having different bit depths, and to allow different bit depths for different components of a video signal by compressing each with the same fidelity (i.e., the same QP).

Abstract: A method and apparatus for matching data network resources with an appropriate group of concepts of an ontology has the steps of, receiving a request indicating at least one expert field, providing at least one data network resource of the expert field having at least one tag and an ontology of the expert field having at least one concept, determining a minimum spanning tree of the concepts in the ontology corresponding to the tags of the data network resources and returning the concepts of the selected minimum spanning tree in response to the received request. The data network resources is matched thematically related to concepts of an ontology to the concepts of an ontology without knowing the exact terms used in the concepts and vice versa. It can be used by experts to search resources created by laymen using their expert terms without the need to know these terms.

Abstract: The quantization parameter QP is well-known in digital video compression as an indication of picture quality. Digital symbols representing a moving image are quantized with a quantizing step that is a function QSN of the quantization parameter QP, which function QSN has been normalized to the most significant bit of the bit depth of the digital symbols. As a result, the effect of a given QP is essentially independent of bit depth a particular QP value has a standard effect on image quality, regardless of bit depth. The invention is useful, for example, in encoding and decoding at different bit depths, to generate compatible, bitstreams having different bit depths, and to allow different bit depths for different components of a video signal by compressing each with the same fidelity (i.e., the same QP).

Abstract: The quantization parameter QP is well-known in digital video compression as an indication of picture quality. Digital symbols representing a moving image are quantized with a quantizing step that is a function QSN of the quantization parameter QP, which function QSN has been normalized to the most significant bit of the bit depth of the digital symbols. As a result, the effect of a given QP is essentially independent of bit depth—a particular QP value has a standard effect on image quality, regardless of bit depth. The invention is useful, for example, in encoding and decoding at different bit depths, to generate compatible, bitstreams having different bit depths, and to allow different bit depths for different components of a video signal by compressing each with the same fidelity (i.e., the same QP).

Abstract: A membrane-permeation test for evaluating pharmaceutical compositions is described. The method comprises the following steps: (1) providing a microporous membrane having a plurality of pores, the membrane having a feed side and a permeate side, wherein the feed side of the membrane is in fluid communication with the feed solution, and wherein the permeate side of the membrane is in fluid communication with a permeate solution; (2) administering a pharmaceutical composition to an aqueous solution to form a feed solution; and (3) measuring the concentration of drug in the permeate solution; wherein the feed side of the membrane is hydrophilic, and/or wherein the permeate solution comprises an organic fluid.

Abstract: A sustained release solid oral dosage form for treatment of a psychotic disorder, for example schizophrenia, in a mammal is provided, which oral dosage form comprises ziprasidone in an amount effective in treating said psychotic disorder and a pharmaceutically acceptable carrier.

Abstract: A diaphragm pressure measuring cell arrangement has a housing body at least partly made of sapphire material and a planar sapphire diaphragm with a peripheral edge joined by a first edge seal to the housing body to form a reference vacuum chamber. An outer surface of the diaphragm is exposed to a medium to be measured. A ceramic supporting body is attached to the back side of the housing body by sealing glass and includes a surface area overhanging that surrounds the housing body to form a first sealing surface. A tubular sensor casing incorporates the measuring cell for mounted the ceramic support body, the casing including an inside second surrounding sealing surface corresponding to the first sealing surface. A metal ring seal is between the sealing surfaces and a pressing member presses sealing surfaces together.

Abstract: A membrane-permeation test for evaluating pharmaceutical compositions is described. The method comprises the following steps: (1) providing a microporous membrane having a plurality of pores, the membrane having a feed side and a permeate side, wherein the feed side of the membrane is in fluid communication with the feed solution, and wherein the permeate side of the membrane is in fluid communication with a permeate solution; (2) administering a pharmaceutical composition to an aqueous solution to form a feed solution; and (3) measuring the concentration of drug in the permeate solution; wherein the feed side of the membrane is hydrophilic, and/or wherein the permeate solution comprises an organic fluid.

Abstract: A diaphragm pressure measuring cell arrangement has a housing body at least partly made of sapphire material and a planar sapphire diaphragm with a peripheral edge joined by a first edge seal to the housing body to form a reference vacuum chamber. An outer surface of the diaphragm is exposed to a medium to be measured. A ceramic supporting body is attached to the back side of the housing body by sealing glass and includes a surface area overhanging that surrounds the housing body to form a first sealing surface. A tubular sensor casing incorporates the measuring cell for mounted the ceramic support body, the casing including an inside second surrounding sealing surface corresponding to the first sealing surface. A metal ring seal is between the sealing surfaces and a pressing member presses sealing surfaces together.

Abstract: A medical instrument has a rod-shaped body which has a distal end section which can be inserted through a vagina into an uterus. A bell-shaped element is mounted on the rod-shaped body. The bell-shaped element being slidingly displaceable along said rod-shaped body at least between an axial position on said rod-shaped body close to a proximal end thereof and up to said distal end section inserted in an uterus.

Abstract: A semantic multilayer network is established, wherein a first layer in said semantic multilayer network including tag annotations, and a second layer in said semantic multilayer network including data structured by an ontology, are established and wherein the first layer and the second layer are connected. Thus, connecting of two entirely different worlds of the dynamic, emergent “social tagging” (e.g., web applications like Web 2.0) and of the regular “ontology engineering” (e.g. Semantic Web) data, dynamic data tag annotations and ontology, seen as too opposed or conflictive, therefore being treated separately and independently so far, becomes possible. Here, by utilizing advantages of both worlds, computer aided handling of large amounts of data, including e.g. processing, management, or querying of data, becomes considerably efficient and effective, wherein said data may be distributed in different areas, locations, or systems.

Abstract: An intelligent shape is displayed in conjunction with a CAD application program, wherein the intelligent shape selectively displays positioning and alignment aids on the monitor of the computer to assist a user in operating one or more functions of the host application program. When invoked, and a first object is positioned proximate to a second object on the monitor, plugs of the first object are displayed on the first object. The plugs indicate one or more respective attachment points on the first object. A socket is created on the second object when the plug of the first object is placed proximate to the second object. The socket indicates an attachment point between the first object and the second object. The first object and the second object are automatically coupling together at the attachment point.

Abstract: A connector object supports bi-directional connections such that an instance of the connector object may behave as both a socket connector and as a plug connector. A first shape object and a second shape object having a first connector object and second connector object respectively that are instances of the same connector object are displayed on a display device. The first connector object is coupled to the second connector object wherein the first connector object and the second connector object behave both as sockets and plugs. An external connection manager resolves connections. The manager determines: (1) if shape connections should be resolved; and (2) one or more socket connector objects and plug connector objects that need to be updated from one or more other shapes coupled to the determined socket connector objects. Thereafter, the manager recursively updates each determined plug connector object.