Patents by Inventor Walter D. Celmer

Walter D. Celmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 19-epi-dianemycin as an anticoccidial and antibacterial agent
    Patent number: 4707493
    Abstract: Antibiotic 19-epi-dianemycin, process for its preparation by fermenting a new strain of Streptomyces hygroscopicus, and isolation from the fermentation broth; and its use as an anticoccidial agent and antibacterial agent against gram-positive bacteria.
    Type: Grant
    Filed: November 17, 1986
    Date of Patent: November 17, 1987
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Hiroshi Maeda, John C. Ruddock, Junsuke Tone
  • Method of preparing a new polyether antibiotic from streptomyces
    Patent number: 4652523
    Abstract: A new polyether antibiotic has been isolated from fermentations of a new microorganism of the genus Streptomyces. This new microorganism is designated as N478-13 and it has been named Streptomyces routienii Huange sp. nov., (ATCC 30446). The new antibiotic exhibits antibacterial activity against a variety of gram-positive bacteria; it can be used to control swine dysentery; and it promotes increased efficiency of feed utilization (i.e. promotes increased growth) in swine and ruminants.
    Type: Grant
    Filed: October 15, 1984
    Date of Patent: March 24, 1987
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Hiroshi Maeda, Junsuke Tone
  • Acidic polycyclic ether antibiotic
    Patent number: 4625041
    Abstract: A new acidic polycyclic ether antibiotic, CP-63,517, having the formula: ##STR1## and cationic salts thereof produced by submerged aerobic propagation of Streptomyces endus subsp. aureus, ATCC-39574, a new strain of microorganism isolated from a soil sample in Japan, a process for producing this antibiotic and methods for its use to improve feed utilization, promote growth of cattle and swine and to control coccidiosis.
    Type: Grant
    Filed: August 29, 1985
    Date of Patent: November 25, 1986
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Hiroshi Maeda, Junsuke Tone
  • Nocardia species capable of producing nargenicin C.sub.1
    Patent number: 4605624
    Abstract: A new antibiotic substance, which has been named nargenicin C.sub.1, has been isolated from fermentations of a species of the genus Nocardia. Nargenicin C.sub.1 can be used as an antibacterial agent against susceptible bacteria, especially susceptible strains of Staphylococcus aureus.
    Type: Grant
    Filed: January 13, 1984
    Date of Patent: August 12, 1986
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Riichiro Shibakawa, Junsuke Tone
  • Erythromycin D and esters thereof by fermentation with Nocardia sp. ATCC 39043
    Patent number: 4582796
    Abstract: Fermentation of a culture of Nocardia sp. ATCC 39043 produces an antibiotic complex comprising erythromycin D, 3",4"-di-O-acetylerythromycin D, 3"-O-acetyl-4"-O-propionylerythromycin D and 4"-O-acetylerythromycin D. The components are separated and are each useful in vitro and in vivo as antibacterial agents. If erythromycin D is the desired product, the esters can be hydrolyzed prior to the separation of the erythromycin D.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: April 15, 1986
    Assignee: Pfizer, Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Paul C. Watts, Riichiro Shibakawa, Junsuke Tone
  • Process for producing an acidic polycyclic ether antibiotic by cultivation of a novel strain of Streptomyces endus subspecies aureus
    Patent number: 4552843
    Abstract: A new acidic polycyclic ether antibiotic, CP-63,517, having the formula: ##STR1## and cationic salts thereof produced by submerged aerobic propagation of Streptomyces endus subsp. aureus, ATCC-39574, a new strain of microorganism isolated from a soil sample in Japan, a process for producing this antibiotic and methods for its use to improve feed utilization, promote growth of cattle and swine and to control coccidiosis.
    Type: Grant
    Filed: February 17, 1984
    Date of Patent: November 12, 1985
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Hiroshi Maeda, Junsuke Tone
  • Polyether antibiotic from streptomyces
    Patent number: 4547523
    Abstract: A new polyether antibiotic has been isolated from fermentations of a new microorganism of the genus Streptomyces. This new microorganism is designated as N478-13 and it has ben named Streptomyces routienii Huang sp. nov., (ATCC 39446). The new antibiotic exhibits antibacterial activity against a variety of gram-positive bacteria; it can be used to control swine dysentery; and it promotes increased efficiency of feed utilization (i.e. promotes increased growth) in swine and ruminants.
    Type: Grant
    Filed: November 7, 1983
    Date of Patent: October 15, 1985
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Hiroshi Maeda, Junsuke Tone
  • Streptomyces capable of producing neutral macrolide antibacterial agents
    Patent number: 4543334
    Abstract: An antibiotic complex, consisting of one major and two minor components, has been isolated from fermentation of a new Streptomyces culture. The components from the complex are three new macrolides which are active as antibacterial agents against certain gram-negative and gram-positive microorganisms.
    Type: Grant
    Filed: December 16, 1983
    Date of Patent: September 24, 1985
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Hiroshi Maeda, Junsuke Tone
  • Polycyclic ether antibiotic
    Patent number: 4533553
    Abstract: Growth of cattle and swine is promoted and feed utilization efficiency increased by an improved nutrient feed containing the antibiotic of the formula ##STR1##
    Type: Grant
    Filed: November 9, 1983
    Date of Patent: August 6, 1985
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Riichiro Shibakawa, Junsuke Tone
  • Erythromycin D and esters thereof
    Patent number: 4496546
    Abstract: Fermentation of a culture of Nocardia sp. ATCC 39043 produces an antibiotic complex comprising erythromycin D, 3",4"-di-O-acetylerythromcyin D, 3"-O-acetyl-4"-O-propionylerythromycin D and 4"-O-acetylerythromycin D. The components are separated and are each useful in vitro and in vivo as antibacterial agents. If erythromycin D is the desired product, the esters can be hydrolyzed prior to the separation of the erythromycin D.
    Type: Grant
    Filed: April 12, 1982
    Date of Patent: January 29, 1985
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Paul C. Watts, Riichiro Shibakawa, Junsuke Tone
  • Streptomyces albus subspecies indicus
    Patent number: 4450237
    Abstract: An antibiotic complex, consisting of two major components, has been isolated from fermentations of a new subspecies of Streptomyces albus culture. The two major components from the complex are two new macrolide antibiotics, which are active as antibacterial agents against certain gram-positive and gram-negative microorganisms.
    Type: Grant
    Filed: September 6, 1983
    Date of Patent: May 22, 1984
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Riichiro Shibakawa, Junsuke Tone
  • Nargenicin C.sub.1
    Patent number: 4436747
    Abstract: A new antibiotic substance, which has been named nargenicin C.sub.1, has been isolated from fermentations of a species of the genus Nocardia. Nargenicin C.sub.1 can be used as an antibacterial agent against susceptible bacteria, especially susceptible strains of Staphylococcus aureus.
    Type: Grant
    Filed: October 21, 1982
    Date of Patent: March 13, 1984
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Riichiro Shibakawa, Junsuke Tone
  • Polycyclic ether antibiotic
    Patent number: 4431801
    Abstract: An antibiotic having the formula ##STR1## and the pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: July 23, 1982
    Date of Patent: February 14, 1984
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Riichiro Shibakawa, Junsuke Tone
  • Tylosin macrolide antibiotics from streptomyces
    Patent number: 4411892
    Abstract: An antibiotic complex, consisting of two major components, has been isolated from fermentations of a new subspecies of Streptomyces albus culture. The two major components from the complex are two new macrolide antibiotics, which are active as antibacterial agents against certain gram-positive and gram-negative microorganisms.
    Type: Grant
    Filed: May 3, 1982
    Date of Patent: October 25, 1983
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Riichiro Shibakawa, Junsuke Tone
  • Polycyclic ether antibiotic
    Patent number: 4361649
    Abstract: A new acidic polycyclic ether antibiotic has the formula: ##STR1## and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Streptomyces halstedii ATCC 31812. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth in poultry and ruminants.
    Type: Grant
    Filed: July 20, 1981
    Date of Patent: November 30, 1982
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Riichiro Shibakawa, Junsuke Tone
  • Antibiotics produced by a new microbe, Catenuloplanes japonicus
    Patent number: 4287182
    Abstract: Antibiotics CP-54,715 and CP-54,716, identified by their analytical characteristics, are produced by fermentation of a new microbial species Catenuloplanes jaonicus in a new genus Catenuloplanes and are active against gram-positive and anaerobic infections.
    Type: Grant
    Filed: July 2, 1980
    Date of Patent: September 1, 1981
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Liang H. Huang, John R. Oscarson, Riichiro Shibakawa, Junsuke Tone
  • Ansamycin antibiotic
    Patent number: 4247462
    Abstract: A new subspecies of Streptomyces nigellus Prokop, designated Streptomyces nigellus Prokop subsp. africanus Huang subsp. nov. ATCC 31496, when propagated under aerobic conditions in aqueous nutrient media, produces a mixture of antibiotics. One of these antibiotics is the known macrolide antibiotic cirramycin A; the ansamycin antibiotic is an analogue of protostreptovaricin and the structure has been established as 21-hydroxy, 25-demethyl, 25-methylthioprotostreptovaricin I.
    Type: Grant
    Filed: January 3, 1980
    Date of Patent: January 27, 1981
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, John R. Oscarson, Liang H. Huang, Riichiro Shibakawa, Junsuke Tone
  • Process for producing new ansamycin antibiotic
    Patent number: 4225674
    Abstract: A new subspecies of Streptomyces nigellus Prokop, designated Streptomyces nigellus Prokop subsp. africanus Huang subsp. nov. ATCC 31496, when propagated under aerobic conditions in aqueous nutrient media, produces a mixture of antibiotics. One of these antibiotics is the known macrolide antibiotic cirramycin A; the ansamycin antibiotic is an analogue of protostreptovaricin and the structure has been established as 21-hydroxy, 25-demethyl, 25-methylthioprotostreptovaricin I.
    Type: Grant
    Filed: April 30, 1979
    Date of Patent: September 30, 1980
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, John R. Oscarson, Liang H. Huang, Riichiro Shibakawa, Junsuke Tone
  • Antibiotics produced by species of Nocardia
    Patent number: 4224314
    Abstract: A species of Nocardia, designated Nocardia argentinensis Huang ATCC 31438, when subjected to aerobic submerged fermentation, produces an antibiotic complex containing as its major component antibiotic Compound 51,467. Methods for the recovery and purification of antibiotic Compound 51,467 and minor antibiotic components, Compounds 52,726 and 52,748, and some of their properties are outlined.
    Type: Grant
    Filed: March 2, 1979
    Date of Patent: September 23, 1980
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Paul C. Watts, Walter P. Cullen, Liang H. Huang, Riichiro Shibakawa, Junsuke Tone
  • Process for producing nocardicin A
    Patent number: 4212944
    Abstract: A new species of Nocardiopsis, designated Nocardiopsis atra Huang sp. nov. ATCC 31511, when aerobically propagated in an aqueous nutrient medium, produces nocardicin A in good yield.
    Type: Grant
    Filed: June 4, 1979
    Date of Patent: July 15, 1980
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Liang H. Huang, Mark T. Jefferson, Hiroshi Maeda, Kozo Inoue, Riichiro Shibakawa