Abstract: Crystalline lestaurtinib hydrates and crystalline lestaurtinib hemihydrate hemicetonitrileate and crystalline lestaurtinib hemihydrate hemitetrahydrofuranate, processes to reproducibly make them and methods of treating patients using them are disclosed.

Abstract: Lestaurtinib Crystalline Form 1, isolated crystalline lestaurtinib anhydrate and amorphous lestaurtinib, processes to reproducibly make them and methods of treating patients using them.

Abstract: A method and apparatus for measuring isotherms and determining solid state phase changes comprising a humidity generator having a temperature controlled internal chamber, a microbalance mounted externally to the internal chamber and a near infrared spectroscopy (NIRS) probe or Raman spectrometer probe mounted internally in the internal chamber, such that the mass of a sample suspended within the chamber and its solid state phase can be determined without disturbing the controlled environment surrounding the sample. The humidity generator includes means for controlling humidity and temperature within the internal chamber, an access port that extends into the internal chamber. The balance is situated near the port such that the balance mechanism extends within the internal chamber. The balance mechanism utilizes a means for holding a sample within the chamber such that the mass of the sample can be determined as it equilibrates to the temperature and relative humidity maintained within the internal cavity.

Abstract: A method and apparatus for measuring isotherms and determining solid state phase changes comprising a humidity generator having a temperature controlled internal chamber, a microbalance mounted externally to the internal chamber and a near infrared spectroscopy (NIRS) probe or Raman spectrometer probe mounted internally in the internal chamber, such that the mass of a sample suspended within the chamber and its solid state phase can be determined without disturbing the controlled environment surrounding the sample. The humidity generator includes means for controlling humidity and temperature within the internal chamber, an access port that extends into the internal chamber. The balance is situated near the port such that the balance mechanism extends within the internal chamber. The balance mechanism utilizes a means for holding a sample within the chamber such that the mass of the sample can be determined as it equilibrates to the temperature and relative humidity maintained within the internal cavity.

Abstract: A method and apparatus for measuring isotherms and determining solid state phase changes comprising a humidity generator having a temperature controlled internal chamber, a microbalance mounted externally to the internal chamber and a near infrared spectroscopy (NIRS) probe or Raman spectrometer probe mounted internally in the internal chamber, such that the mass of a sample suspended within the chamber and its solid state phase can be determined without disturbing the controlled environment surrounding the sample. The humidity generator includes means for controlling humidity and temperature within the internal chamber, an access port that extends into the internal chamber. The balance is situated near the port such that the balance mechanism extends within the internal chamber. The balance mechanism utilizes a means for holding a sample within the chamber such that the mass of the sample can be determined as it equilibrates to the temperature and relative humidity maintained within the internal cavity.

Abstract: Lestaurtinib Crystalline Form 1, isolated crystalline lestaurtinib anhydrate and amorphous lestaurtinib, processes to reproducibly make them and methods of treating patients using them.

Abstract: Crystalline lestaurtinib hydrates and crystalline lestaurtinib hemihydrate hemicetonitrileate and crystalline lestaurtinib hemihydrate hemitetrahydrofuranate, processes to reproducibly make them and methods of treating patients using them are disclosed.

Abstract: A method and apparatus for measuring isotherms and determining solid state phase changes comprising a humidity generator having a temperature controlled internal chamber, a microbalance mounted externally to the internal chamber and a near infrared spectroscopy (NIRS) probe or Raman spectrometer probe mounted internally in the internal chamber, such that the mass of a sample suspended within the chamber and its solid state phase can be determined without disturbing the controlled environment surrounding the sample. The humidity generator includes means for controlling humidity and temperature within the internal chamber, an access port that extends into the internal chamber. The balance is situated near the port such that the balance mechanism extends within the internal chamber. The balance mechanism utilizes a means for holding a sample within the chamber such that the mass of the sample can be determined as it equilibrates to the temperature and relative humidity maintained within the internal cavity.

Abstract: A method and apparatus for measuring isotherms and determining solid state phase changes comprising a humidity generator having a temperature controlled internal chamber, a microbalance mounted externally to the internal chamber and a near infrared spectroscopy (NIRS) probe or Raman spectrometer probe mounted internally in the internal chamber, such that the mass of a sample suspended within the chamber and its solid state phase can be determined without disturbing the controlled environment surrounding the sample. The humidity generator includes means for controlling humidity and temperature within the internal chamber, an access port that extends into the internal chamber. The balance is situated near the port such that the balance mechanism extends within the internal chamber. The balance mechanism utilizes a means for holding a sample within the chamber such that the mass of the sample can be determined as it equilibrates to the temperature and relative humidity maintained within the internal cavity.

Abstract: Atrasentan Hydrochloride Crystalline Form 2, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.