Patents by Inventor Walter E. DeWolf
Walter E. DeWolf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8173646Abstract: Compounds of the Formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.Type: GrantFiled: July 6, 2010Date of Patent: May 8, 2012Assignee: Affinium Pharmaceuticals, Inc.Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. Dewolf, Jr., Dalia R. Jakas
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Publication number: 20110190283Abstract: Compounds of the Formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.Type: ApplicationFiled: July 6, 2010Publication date: August 4, 2011Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. DeWolf, JR., Dalia R. Jakas
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Patent number: 7790716Abstract: Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.Type: GrantFiled: March 12, 2009Date of Patent: September 7, 2010Assignee: Affinium Pharmaceuticals, Inc.Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. Dewolf, Jr., Dalia R. Jakas
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Publication number: 20090275572Abstract: Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.Type: ApplicationFiled: March 12, 2009Publication date: November 5, 2009Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. Dewolf, JR., Dalia R. Jakas
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Patent number: 7557125Abstract: Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.Type: GrantFiled: December 9, 2004Date of Patent: July 7, 2009Assignee: Affinium Pharmaceuticals, Inc.Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. DeWolf, Dalia R. Jakas
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Patent number: 7524843Abstract: Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.Type: GrantFiled: July 18, 2007Date of Patent: April 28, 2009Assignee: Affinium Pharmaceuticals, Inc.Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. Dewolf, Jr., Dalia R. Jakas
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Publication number: 20080125423Abstract: Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.Type: ApplicationFiled: July 18, 2007Publication date: May 29, 2008Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. Dewolf, Dalia R. Jakas
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Patent number: 7056697Abstract: The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabK polypeptides to screen for antibacterial compounds.Type: GrantFiled: November 26, 2002Date of Patent: June 6, 2006Assignee: Affinium Pharmaceuticals, Inc.Inventors: Walter E. DeWolf, Jr., David John Payne, Nicola Gail Wallis, Joshua M. West
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Patent number: 7048926Abstract: The invention provides methods for using agonists and antagonists of FabK polypeptides, particularly to modulate the metabolism of bacteria or to treat bacterial infection.Type: GrantFiled: April 4, 2003Date of Patent: May 23, 2006Assignee: Affinium Pharmaceuticals, Inc.Inventors: Martin Brandt, Walter E. DeWolf, Jr., Paul M. Keller, Arunbhai H. Patel, David J. Payne, Shannon L. Reed, Mark A. Seefeld, David G. Tew, Nicola G. Wallis, Joshua M. West
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Patent number: 7033795Abstract: The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing FabK polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.Type: GrantFiled: November 26, 2002Date of Patent: April 25, 2006Assignee: Affinium Pharmaceuticals, Inc.Inventors: Walter E. DeWolf, Jr., David John Payne, Nicola Gail Wallis, Joshua M. West
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Patent number: 6951729Abstract: Provided is a screening method for compounds affecting fatty acid biosynthesis, the method comprising: providing a reaction mixture comprising: an acyl carrier moiety or enzymes and precursors sufficient to generate the acyl carrier moiety; a bacterial enzymatic pathway comprising at least two consecutively acting enzymes selected from the group consisting of: malonyl-CoA:ACP transacylase, beta-ketoacyl-ACP synthase III, NADPH dependent beta-ketoacyl-ACP reductase, beta-hydroxylacyl-ACP dehydrase and enoyl-ACP reductase; and substrates and cofactors required for the operation of the enzymes; contacting the reaction mixture with a prospective bioactive agent; conducting a high throughput measurement of the activity of the enzymatic pathway; and determining if the contacting altered the activity of the enzymatic pathway.Type: GrantFiled: October 26, 2000Date of Patent: October 4, 2005Assignee: Affinium Pharmaceuticals, Inc.Inventors: Walter E Dewolf, Jr., Howard Kallender, John T Lonsdale
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Patent number: 6846819Abstract: Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.Type: GrantFiled: October 6, 2000Date of Patent: January 25, 2005Assignee: Affinium Pharmaceuticals, Inc.Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. DeWolf, Jr., Dalia R. Jakas
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Patent number: 6821746Abstract: The invention provides methods for identifying agonists and antagonists of FabK polypeptides.Type: GrantFiled: October 1, 2001Date of Patent: November 23, 2004Assignee: Affinium Pharmaceuticals, Inc.Inventors: Walter E. DeWolf, Jr., David John Payne, Nicola Gail Wallis, Joshua M. West
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Publication number: 20040137548Abstract: The invention provides methods for identifying agonists and antagonists of FabK polypeptides.Type: ApplicationFiled: October 1, 2001Publication date: July 15, 2004Inventors: Walter E. DeWolf, David John Payne, Nicola Gail Wallis, Joshua M. West
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Publication number: 20040053814Abstract: The invention provides methods for using agonists and antagonists of FabK polypeptides, particularly to modulate the metabolism of bacteria or to treat bacterial infection.Type: ApplicationFiled: April 4, 2003Publication date: March 18, 2004Inventors: Martin Brandt, Walter E. Dewolf, Paul M. Keller, Arunbhai H. Patel, David J. Payne, Shannon L. Reed, Mark A. Seefeld, David G. Tew, Nicola G. Wallis, Joshua M. West
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Publication number: 20030175758Abstract: The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing FabK polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.Type: ApplicationFiled: November 26, 2002Publication date: September 18, 2003Applicant: SmithKline Beecham CorporationInventors: Walter E. DeWolf, David John Payne, Nicola Gail Wallis, Joshua M. West
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Publication number: 20030175757Abstract: The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabK polypeptides to screen for antibacterial compounds.Type: ApplicationFiled: November 26, 2002Publication date: September 18, 2003Applicant: SmithKline Beecham CorporationInventors: Walter E. DeWolf, David John Payne, Nicola Gail Wallis, Joshua M. West