Patents by Inventor Walter E. DeWolf, Jr.

Walter E. DeWolf, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FAB I inhibitors
    Patent number: 8173646
    Abstract: Compounds of the Formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: May 8, 2012
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. Dewolf, Jr., Dalia R. Jakas
  • Fab I Inhibitors
    Publication number: 20110190283
    Abstract: Compounds of the Formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
    Type: Application
    Filed: July 6, 2010
    Publication date: August 4, 2011
    Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. DeWolf, JR., Dalia R. Jakas
  • Fab I inhibitors
    Patent number: 7790716
    Abstract: Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: September 7, 2010
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. Dewolf, Jr., Dalia R. Jakas
  • FAB I INHIBITORS
    Publication number: 20090275572
    Abstract: Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
    Type: Application
    Filed: March 12, 2009
    Publication date: November 5, 2009
    Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. Dewolf, JR., Dalia R. Jakas
  • Fab I inhibitors
    Patent number: 7524843
    Abstract: Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: April 28, 2009
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. Dewolf, Jr., Dalia R. Jakas
  • FabK variant
    Patent number: 7056697
    Abstract: The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabK polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: June 6, 2006
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Walter E. DeWolf, Jr., David John Payne, Nicola Gail Wallis, Joshua M. West
  • Methods of agonizing and antagonizing FabK
    Patent number: 7048926
    Abstract: The invention provides methods for using agonists and antagonists of FabK polypeptides, particularly to modulate the metabolism of bacteria or to treat bacterial infection.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: May 23, 2006
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Martin Brandt, Walter E. DeWolf, Jr., Paul M. Keller, Arunbhai H. Patel, David J. Payne, Shannon L. Reed, Mark A. Seefeld, David G. Tew, Nicola G. Wallis, Joshua M. West
  • FabK variant
    Patent number: 7033795
    Abstract: The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing FabK polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: April 25, 2006
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Walter E. DeWolf, Jr., David John Payne, Nicola Gail Wallis, Joshua M. West
  • High throughput screening method for biological agents affecting fatty acid biosynthesis
    Patent number: 6951729
    Abstract: Provided is a screening method for compounds affecting fatty acid biosynthesis, the method comprising: providing a reaction mixture comprising: an acyl carrier moiety or enzymes and precursors sufficient to generate the acyl carrier moiety; a bacterial enzymatic pathway comprising at least two consecutively acting enzymes selected from the group consisting of: malonyl-CoA:ACP transacylase, beta-ketoacyl-ACP synthase III, NADPH dependent beta-ketoacyl-ACP reductase, beta-hydroxylacyl-ACP dehydrase and enoyl-ACP reductase; and substrates and cofactors required for the operation of the enzymes; contacting the reaction mixture with a prospective bioactive agent; conducting a high throughput measurement of the activity of the enzymatic pathway; and determining if the contacting altered the activity of the enzymatic pathway.
    Type: Grant
    Filed: October 26, 2000
    Date of Patent: October 4, 2005
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Walter E Dewolf, Jr., Howard Kallender, John T Lonsdale
  • Fab I inhibitors
    Patent number: 6846819
    Abstract: Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: January 25, 2005
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas, Walter E. DeWolf, Jr., Dalia R. Jakas
  • Methods of screening for FabK antagonists and agonists
    Patent number: 6821746
    Abstract: The invention provides methods for identifying agonists and antagonists of FabK polypeptides.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: November 23, 2004
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Walter E. DeWolf, Jr., David John Payne, Nicola Gail Wallis, Joshua M. West