Abstract: This disclosure provides a hydrocolloid having a super absorbent material chemically bonded either directly or indirectly to a peroxide. The peroxide is within the hydrocolloid and the peroxide is in an amount of 0.05% to 2% by weight within the hydrocolloid.

Abstract: This disclosure provides a hydrocolloid having a super absorbent material chemically bonded either directly or indirectly to a peroxide. The peroxide is within the hydrocolloid and the peroxide is in an amount of 0.05% to 2% by weight within the hydrocolloid.

Abstract: This disclosure provides a method of preparing a hydrocolloid adhesive that includes the steps of mixing one or more components to produce a continuous phase, heating the continuous phased to a predetermined temperature between about 135° C. to 170° C., adding a stabilizer to the continuous phase, reducing a temperature of the continuous phase to a second predetermined temperature below 99° C., adding a discontinuous phase to the continuous phase at the second predetermined temperature, and mixing the components of the discontinuous phase and the continuous phase to produce a uniform mixture. Further, the hydrocolloid adhesive includes a super absorbent material and 0.05% to 2% by weight of a peroxide.

Abstract: This disclosure provides a method of preparing a hydrocolloid adhesive that includes the steps of mixing one or more components to produce a continuous phase, heating the continuous phased to a predetermined temperature between about 135° C. to 170° C., adding a stabilizer to the continuous phase, reducing a temperature of the continuous phase to a second predetermined temperature below 99° C., adding a discontinuous phase to the continuous phase at the second predetermined temperature, and mixing the components of the discontinuous phase and the continuous phase to produce a uniform mixture. Further, the hydrocolloid adhesive includes a super absorbent material and 0.05% to 2% by weight of a peroxide.

Abstract: This disclosure provides for an antimicrobial pressure sensitive adhesive composition that includes a sequestered peroxide source and devices that incorporate such a composition.

Abstract: Coupling systems including interlocking male and female members are disclosed herein. An example apparatus includes a first coupling including a sidewall having an annular spring. The example apparatus also includes a second coupling to be coupled to the first coupling. The second coupling has an annular wall including a seal. The seal is to sealingly engage the annular spring when the second coupling is coupled to the first coupling.

Abstract: A wound dressing having a thin barrier layer of soft, pliant adhesive material with a flexible cover layer extending along one side of the adhesive layer and a removable release sheet on the opposite side is disclosed. The adhesive material has a center and border surrounding the center such that the adhesive is contoured. A method for making the contoured dressing using a gear pump and a laminating roller having a predetermined softness and firmness is also disclosed.

Abstract: This disclosure provides for an antimicrobial pressure sensitive adhesive composition that includes a sequestered peroxide source and devices that incorporate such a composition.

Abstract: Coupling systems including interlocking male and female members are disclosed herein. An example apparatus includes a first coupling including a sidewall having an annular spring. The example apparatus also includes a second coupling to be coupled to the first coupling. The second coupling has an annular wall including a seal. The seal is to sealingly engage the annular spring when the second coupling is coupled to the first coupling.

Abstract: A wound dressing having a thin barrier layer of soft, pliant adhesive material with a flexible cover layer extending along one side of the adhesive layer and a removable release sheet on the opposite side is disclosed. The adhesive material has a center and border surrounding the center such that the adhesive is contoured. A method for making the contoured dressing using a gear pump and a laminating roller having a predetermined softness and firmness is also disclosed.

Abstract: The portable environmental control chamber provides gas, as needed, to encourage healing and prevent infection. In one embodiment, the environmental control chamber acts as a hyperbaric chamber that can be affixed over a wound to supply oxygen to the wound bed. In another embodiment, the environmental control chamber acts as a catheter tent that prevents microbes from entering the catheter site. The environmental control chamber comprises a gas impermeable film that forms a tent over a wound or catheter site to which is attached two or more flexible ports that allow gas to be applied to a site. The chamber is attached to the body using an adhesive.

Abstract: Embodiments of the invention relate to vector constructs and methods for expression of polypeptides including multimeric products such as therapeutic antibodies. Particular constructs allow for the generation of expression products from a single open reading frame (sORF). An embodiment provides an isolated or purified expression vector for generating one or more recombinant protein products comprising a single open reading frame insert; said insert comprising a signal peptide nucleic acid sequence encoding a signal peptide; a first nucleic acid sequence encoding a first polypeptide; a first intervening nucleic acid sequence encoding a first protein cleavage site, wherein said first protein cleavage site is provided by an intein segment of a Ion protease gene of Pyrococcus or a klbA gene of Pyrococcus or Methanococcus, or a modified intein segment derived therefrom; and a second nucleic acid sequence encoding a second polypeptide.

Abstract: A method for producing a soft convex adhesive wafer for attaching an ostomy appliance to a peristomal skin surface surrounding a stoma. In one embodiment, the method includes providing a resilient laminating pad adapted for being displaced to and fro in a laminating direction and that exerts a laminating pressure in the laminating direction, providing a plane counter-pressure surface at substantially right angles to the laminating direction, placing the wafer on the counter-pressure surface, and displacing the laminating pad in the laminating direction so that laminating pressure is exerted on an entire distal surface of the wafer by the laminating pad.

Abstract: A convex adapter for ostomy appliances is disclosed, the adapter including an adapter ring formed entirely of a soft, tacky, moisture-absorbent and swellable, hydrocolloid-containing adhesive material, one that retains its integrity on hydration and is shape-recoverable when compressive forces are removed, and a thin substantially non-stretchable cover film extending over and beyond the convex bodyside surface of that ring. The film is removably attached to the ring and is preferably transparent (or translucent) so that at least the outline of the ring may be seen through it. A flexible but substantially non-stretchable release sheet is removably attached to the opposite pouchside surface of the ring and may be peeled away from the ring during an initial step in the use of the product.

Abstract: A drainable ostomy pouch having at least one arcuate spring member, and preferably two such spring members, adjacent the discharge opening at the lower end of the pouch is disclosed. Each wall of the pouch with such arcuate spring member is normally bowed outwardly from the other wall to hold the discharge opening in open condition for draining of the pouch's contents. To seal the discharge opening, the lower end of the pouch is folded upwardly to force the spring member(s) into flattened condition, and the pouch's lower end is then secured in such upwardly-folded condition.

Abstract: A snap-in insert is disclosed for use with the faceplate of an ostomy appliance. The faceplate includes a convex pressure ring and an adhesive barrier pad or wafer that extends over the convex surface of that ring. The insert has an apertured support wall that is flexible but sufficiently stiff to support and thereby brace the barrier pad about the faceplate's stoma-receiving opening.

Abstract: An adhesive wafer for attaching an ostomy appliance to a peristomal skin surface surrounding a stoma has an integrally molded adhesive layer made of a skin barrier material, a distal surface covered by a flexible backing layer, and a proximal bodyside surface contoured so the adhesive layer has a thin peripheral portion and thick central portion surrounding a stoma-receiving aperture. A set of at least two wafers is provided in one embodiment, wherein individual wafers have differing central portion surface topography, and different stoma receiving apertures. To produce a closely fitting wafer for a given stoma, a method of producing wafers includes providing a representation of the topography of the peristomal surface and the stoma, and, using the representation, manufacturing a mold having a surface configuration substantially matching the topography of the peristomal surface and stoma.

Abstract: A convex adapter for ostomy appliances, including an adapter ring formed entirely of soft, moisture-absorbent, hydrocolloid-containing adhesive material that retains its integrity on hydration and is shape-recoverable, and a thin stretchable cover film (preferably transparent or translucent) removably covering and extending over and beyond the ring's convex bodyside surface. A flexible but substantially non-stretchable release sheet is removably attached to the opposite pouchside surface of the ring and may be peeled away from the ring during an initial step in the use of the product. With the release sheet so removed, a user may grasp adapter ring and its cover film and reform the ring so that its opening is sized and shaped to match a patient's stoma, after which the reformed adapter ring is adhered to the adhesive faceplate of an ostomy appliance, the cover film is removed, and the combination faceplate/adapter is adhesively secured to a patient's peristomal skin surfaces.

Abstract: A snap-in insert is disclosed for use with the faceplate of an ostomy appliance. The faceplate includes a convex pressure ring and an adhesive barrier pad or wafer that extends over the convex surface of that ring. The insert has an apertured support wall that is flexible but sufficiently stiff to support and thereby brace the barrier pad about the faceplate's stoma-receiving opening.

Abstract: A convex adapter for ostomy appliances is disclosed, the adapter including an adapter ring formed entirely of a soft, tacky, moisture-absorbent and swellable, hydrocolloid-containing adhesive material, one that retains its integrity on hydration and is shape-recoverable when compressive forces are removed, and a thin substantially non-stretchable cover film extending over and beyond the convex bodyside surface of that ring. The film is removably attached to the ring and is preferably transparent (or translucent) so that at least the outline of the ring may be seen through it. A flexible but substantially non-stretchable release sheet is removably attached to the opposite pouchside surface of the ring and may be peeled away from the ring during an initial step in the use of the product.