Patents by Inventor Walter F. Mangel

Walter F. Mangel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecular sleds and uses thereof
    Patent number: 10065989
    Abstract: The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: September 4, 2018
    Assignees: The Broad Institute Inc., President and Fellows of Harvard College, Rijksuniversiteit Groningen
    Inventors: Walter F. Mangel, Paul Blainey, Vito Graziano, Andreas Herrmann, William J. McGrath, Antonius Martinus Van Oijen, Xiaoliang Sunney Xie
  • MOLECULAR SLEDS AND USES THEREOF
    Publication number: 20150210738
    Abstract: The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.
    Type: Application
    Filed: January 13, 2015
    Publication date: July 30, 2015
    Inventors: Walter F. MANGEL, Paul BLAINEY, Vito GRAZIANO, Andreas HERRMANN, William J. MCGRATH, Antonius Martinus VAN OIJEN, Xiaoliang Sunney XIE
  • Activated recombinant adenovirus proteinases
    Patent number: 5935840
    Abstract: This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: August 10, 1999
    Assignee: Associated Universities, Inc.
    Inventors: Carl W. Anderson, Walter F. Mangel
  • Co-factor activated recombinant adenovirus proteinases
    Patent number: 5543264
    Abstract: This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.
    Type: Grant
    Filed: November 19, 1993
    Date of Patent: August 6, 1996
    Assignee: Associated Universities, Inc.
    Inventors: Carl W. Anderson, Walter F. Mangel
  • Novel rhodamine derivatives as fluorogenic substrates for proteinases
    Patent number: 4640893
    Abstract: The present invention relates to a new class of novel Rhodamine derivatives. These derivatives which are bisamide substitution products are nonfluorescent. Whereas the monoamide substitution products exhibit high fluorescence. Cleavage of a single specified amide bond by bond-specific proteinases will therefore convert the nonfluorescent bisamide derivative into a highly fluorescent monoamide derivative.
    Type: Grant
    Filed: September 27, 1985
    Date of Patent: February 3, 1987
    Assignee: University of Illinois
    Inventors: Walter F. Mangel, Stephen Leytus, L. Lee Melhado
  • Rhodamine derivatives as fluorogenic substrates for proteinases
    Patent number: 4557862
    Abstract: The present invention relates to a new class of novel Rhodamine derivatives. These derivatives which are bisamide substitution products are nonfluorescent. Whereas the monoamide substitution products exhibit high fluorescence. Cleavage of a single specified amide bond by bond-specific proteinases will therefore convert the nonfluorescent bisamide derivative into a highly fluorescent monoamide derivative.
    Type: Grant
    Filed: October 28, 1983
    Date of Patent: December 10, 1985
    Assignee: University Patents, Inc.
    Inventors: Walter F. Mangel, Stephen Leytus, L. Lee Melhado