Patents by Inventor Walter Ferdinand Maria Filliers

Walter Ferdinand Maria Filliers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLINE Pl3 KINASE INHIBITORS
    Publication number: 20170239256
    Abstract: There is provided inter alia 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-di hydroquinazolin-5-yl)-N, N-bis(2-methoxyethyl)hex-5-ynamide in the form of a solid crystalline hydrate and in solid crystalline anhydrous form. There are also provided dry powder pharmaceutical compositions for inhalation containing such solid crystalline forms.
    Type: Application
    Filed: May 8, 2017
    Publication date: August 24, 2017
    Applicant: Respivert Limited
    Inventors: Rudy Laurent Maria Broeckx, Walter Ferdinand Maria Filliers, Patrick Hubert, J Nieste, Alex Herman Copmans, Filip Marcel Vanhoutte, Carina Leys
  • Crystalline 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-D]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-4-0X0-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide
    Patent number: 9642799
    Abstract: There is provided inter alia 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide in the form of a solid crystalline hydrate and in solid crystalline anhydrous form. There are also provided dry powder pharmaceutical compositions for inhalation containing such solid crystalline forms.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: May 9, 2017
    Assignee: Respivert, Ltd.
    Inventors: Rudy Laurent Maria Broeckx, Walter Ferdinand Maria Filliers, Patrick Hubert J Nieste, Alex Herman Copmans, Filip Marcel Vanhoutte, Carina Leys
  • Process for the preparation of compounds useful as inhibitors of SGLT
    Patent number: 9056850
    Abstract: The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: June 16, 2015
    Assignees: Janssen Pharmaceutica N.V., Mitsubishi Tanabe Pharma Corporation
    Inventors: Walter Ferdinand Maria Filliers, Rudy Laurent Maria Broeckx, Patrick Hubert J. Nieste, Masanori Hatsuda, Masahiko Yoshinaga, Mitsuhiro Yada, Christopher Teleha
  • CRYSTALLINE Pl3 KINASE INHIBITORS
    Publication number: 20150105408
    Abstract: There is provided inter alia 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide in the form of a solid crystalline hydrate and in solid crystalline anhydrous form. There are also provided dry powder pharmaceutical compositions for inhalation containing such solid crystalline forms.
    Type: Application
    Filed: March 13, 2013
    Publication date: April 16, 2015
    Inventors: Rudy Laurent Maria Broeckx, Walter Ferdinand Maria Filliers, Patrick Hubert, J Nieste, Alex Herman Copmans, Filip Marcel Vanhoutte, Carina Leys
  • NOVEL PHARMACEUTICAL FORMULATIONS
    Publication number: 20150099768
    Abstract: There is provided inter alia a dry powder pharmaceutical formulation for inhalation comprising: (i) 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide or a pharmaceutically acceptable salt thereof, including all stereoisomers, tautomers and isotopic derivatives thereof and solvates thereof in particulate form as active ingredient; (ii) particulate lactose as carrier; and (iii) a particulate stabilizing agent selected from metal salts of stearic acid such as magnesium stearate and metal salts of stearyl fumarate.
    Type: Application
    Filed: March 13, 2013
    Publication date: April 9, 2015
    Inventors: Rudy Laurent Maria Broeckx, Walter Ferdinand Maria Filliers, Patrick Hubert J. Nieste, Alex Herman Copmans, Filip Marcel C. Vanhoutte, Carina Leys
  • Synthesis of (2S-cis)-2-(bromomethyl)-2-(4-chlorophenyl)-1,3 dioxolane-4-methanol methanesulfonate(ester)
    Patent number: 8765979
    Abstract: The present invention relates to an improved process for the preparation of (2S-cis)-2-(bromomethyl)-2-(4-chlorophenyl)-1,3-dioxolane-4-methanol methanesulfonate(ester), a key intermediate for the preparation of the apoB secretion/MTP inhibitor mitratapide.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: July 1, 2014
    Assignee: Janssen Pharmaceutica
    Inventors: Walter Ferdinand Maria Filliers, Walter Louis Antoine Verstappen, Ronny Bellinkx
  • Preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine
    Patent number: 8440863
    Abstract: The present invention relates to an improved process for the preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine which is an intermediate for the preparation of the analgesic tapentadol.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: May 14, 2013
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Walter Ferdinand Maria Filliers, Rudy Laurent Maria Broeckx
  • PREPARATION OF (2R,3R)-3-(3-METHOXYPHENYL)-N,N,2 TRIMETHYLPENTANAMINE
    Publication number: 20120142970
    Abstract: The present invention relates to an improved process for the preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine which is an intermediate for the preparation of the analgesic tapentadol.
    Type: Application
    Filed: February 15, 2012
    Publication date: June 7, 2012
    Inventors: Walter Ferdinand Maria Filliers, Rudy Laurent Maria Broeckx
  • Preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine
    Patent number: 8138376
    Abstract: The present invention relates to an improved process for the preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine which is an intermediate for the preparation of the analgesic tapentadol.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: March 20, 2012
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Walter Ferdinand Maria Filliers, Rudy Laurent Maria Broeckx
  • SYNTHESIS OF (2S-CIS)-2-(BROMOMETHYL)-2-(4-CHLOROPHENYL)-1,3 DIOXOLANE-4-METHANOL METHANESULFONATE(ESTER)
    Publication number: 20110196160
    Abstract: The present invention relates to an improved process for the preparation of (2S-cis)-2-(bromomethyl)-2-(4-chlorophenyl)-1,3-dioxolane-4-methanol methanesulfonate(ester), a key intermediate for the preparation of the apoB secretion/MTP inhibitor mitratapide.
    Type: Application
    Filed: May 23, 2008
    Publication date: August 11, 2011
    Inventors: Walter Ferdinand Maria Filliers, Walter Louis Antoine Verstappen, Ronny Bellinkx
  • PREPARATION OF (2R,3R)-3-(3-METHOXYPHENYL)-N,N,2-TRIMETHYLPENTANAMINE
    Publication number: 20090312578
    Abstract: The present invention relates to an improved process for the preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine which is an intermediate for the preparation of the analgesic tapentadol.
    Type: Application
    Filed: July 23, 2007
    Publication date: December 17, 2009
    Inventors: Walter Ferdinand Maria Filliers, Rudy Laurent Maria Broeckx
  • Diastereoselective synthesis process with 6-bromo-4-(3-chlorophenyl)-2-methoxy-quinoline
    Patent number: 7572916
    Abstract: A diastereoselective synthesis process for the preparation of (R)-(+)-6-[amino(4chlorophenyl)(1-methyl-1H-imidazol-5-yl) methyl]-4-(3-chlorophenyl)-1-methyl2(1H)-quinolinone which comprises the preparation of a compound of formula (XVII): and the stereochemically isomeric forms thereof wherein R is C1-6alkyl or C1-6alkylphenyl.
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: August 11, 2009
    Assignee: Janssen Pharmaceutica NV
    Inventors: Walter Ferdinand Maria Filliers, Rudy Laurent Maria Broeckx, Patrick René Angibaud
  • Diastereoselective addition of lithiated N-methylimidazole on sulfinimines
    Patent number: 7524961
    Abstract: A diastereoselective synthesis process for the preparation of (R)-(+)-6-[amino(4-chlorophenyl) (1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2 (1H)-quinolinone which comprises the preparation of a compound of formula (VIII) and the stereochemically isomeric forms thereof wherein R is C1-6alkyl or C1-6alkylphenyl-.
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: April 28, 2009
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Walter Ferdinand Maria Filliers, Rudy Laurent Maria Broeckx, Patrick René Angibaud
  • Diastereoselective synthesis process for the preparation of imidazole compounds
    Patent number: 7456287
    Abstract: A diastereoselective synthesis process for the preparation of an enantiomer of 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone which comprises the conversion of (±)-6-[chloro(4-chlomphenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone into a compound of formula (VIII) wherein aryl is phenyl substituted once or twice with C1-6alkyloxy or naphtalenyl substituted once or twice with C1-6alkyloxy.
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: November 25, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Walter Ferdinand Maria Filliers, Rudy Laurent Maria Broeckx, Patrick René Angibaud
  • Process for the preparation of imidazole compounds
    Patent number: 6844439
    Abstract: A process for the preparation of 4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-1-methyl-2(1H)-quinolinone which comprises reacting 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone with a C6-8alkyllithium compound, 1-methylimidazole and a tri(C4-6alkyl)silyl halide to obtain better yields of the above product.
    Type: Grant
    Filed: March 5, 2002
    Date of Patent: January 18, 2005
    Assignee: Jansen Pharmaceutica, NV
    Inventors: Walter Ferdinand Maria Filliers, Rudy Laurent Maria Broeckx, Stefan Marcel Herman Leurs