Patents by Inventor Walter Francis Prouty

Walter Francis Prouty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for solubilizing glucagon-like peptide 1 compounds
    Patent number: 8455433
    Abstract: Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: June 4, 2013
    Assignee: Eli Lilly and Company
    Inventors: Walter Francis Prouty, Jr., Joseph Vincent Rinella, Jr.
  • PROCESS FOR SOLUBILIZING GLUCAGON-LIKE PEPTIDE 1 COMPOUNDS
    Publication number: 20130072658
    Abstract: Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
    Type: Application
    Filed: August 10, 2012
    Publication date: March 21, 2013
    Applicant: ELI LILLY AND COMPANY
    Inventors: Walter Francis Prouty, JR., Joseph Vincent Rinella, JR.
  • Process for solubilizing glucagon-like peptide 1 compounds
    Patent number: 8268780
    Abstract: Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: September 18, 2012
    Assignee: Eli Lilly and Company
    Inventors: Walter Francis Prouty, Jr., Joseph Vincent Rinella, Jr.
  • PROCESS FOR SOLUBILIZING GLUCAGON-LIKE PEPTIDE 1 COMPOUNDS
    Publication number: 20120208980
    Abstract: Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
    Type: Application
    Filed: April 27, 2012
    Publication date: August 16, 2012
    Applicant: ELI LILLY AND COMPANY
    Inventors: Walter Francis Prouty, JR., Joseph Vincent Rinella, JR.
  • Process for solubilizing glucagon-like peptide 1 compounds
    Patent number: 8222205
    Abstract: Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: July 17, 2012
    Assignee: Eli Lilly and Company
    Inventors: Walter Francis Prouty, Jr., Joseph Vincent Rinella, Jr.
  • PROCESS FOR SOLUBILIZING GLUCAGON-LIKE PEPTIDE 1 COMPOUNDS
    Publication number: 20120101034
    Abstract: Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
    Type: Application
    Filed: September 1, 2009
    Publication date: April 26, 2012
    Inventors: Walter Francis Prouty, JR., Joseph Vincent Rinella, JR.
  • PROCESS FOR SOLUBILIZING GLUCAGON-LIKE PEPTIDE 1 COMPOUNDS
    Publication number: 20110053838
    Abstract: Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
    Type: Application
    Filed: September 1, 2009
    Publication date: March 3, 2011
    Inventors: Walter Francis Prouty, JR., Joseph Vincent Rinella, JR.
  • Process for solubilizing glucagon-like peptide 1 compounds
    Patent number: 7598222
    Abstract: Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: October 6, 2009
    Assignee: Eli Lilly and Company
    Inventors: Walter Francis Prouty, Jr., Joseph Vincent Rinella, Jr.
  • Process for solubilizing glucagon-like peptide 1compounds
    Publication number: 20030060412
    Abstract: Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
    Type: Application
    Filed: June 28, 2002
    Publication date: March 27, 2003
    Inventors: Walter Francis Prouty, Joseph Vincent Rinella