Patents by Inventor Walter G. Brouwer
Walter G. Brouwer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120142676Abstract: Novel derivatives of dihydro-1,4,2-oxathiazine and dihydro-1,4-dithiine oxides, more particularly, novel derivatives of dihydro-1,4,2-oxathiazine and dihydro-1,4-dithiine oxides that target cysteine residues of biomolecules of pharmacological importance are provided as pharmaceutically useful compounds, for example, as anticancer, antiinfectious, antigastric acid secretion, antiosteoporosic, and antiinflammatory agents.Type: ApplicationFiled: July 27, 2011Publication date: June 7, 2012Inventors: Gaik-Lean Chee, Walter G. Brouwer, Ewa Osika, Brian B. Hasinoff, A. David Brewer
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Patent number: 7045512Abstract: A fungicidally active compound of the formula: a) wherein Q is —NY—NH—, —N?N—, or X is oxygen, sulfur, sulfoxide, or sulfone; n is 0 or 1; Y is hydrogen, C1–C4 alkanoyl, C1–C4 haloalkanoyl, C1–C6 straight chain or branched alkoxycarbonyl, C1–C4 alkoxy(C1–C4)alkoxycarbonyl, C1–C4 alkyl, or C1–C4 haloalkyl; R1 is C1–C6 alkoxy, C3–C6 branched alkoxy, C3–C6 cycloalkoxy, phenoxy, benzyloxy, C2–C6 alkenyloxy, C2–C6 alkynyloxy, C1–C6 haloalkoxy, silyloxy, (C1–C6 alkoxy)-carbonylmethoxy, C1–C6 thioalkoxy, C1–C6 alkylamino, C1–C6 alkyl, C3–C6 branched alkyl, (C1–C6 alkoxy) C1–C6 alkoxy, or (C1–C6 alkoxy)carbonyl; R2 and R3 are each, independently, hydrogen, halogen, C1–C6 alkyl, C3–C6 branched alkyl, C1–C6 haloalkyl, C1–C6 alkoxy, C1–C6 haloalkoxy, cyano, or (C1–C6 alkoxy)carbonyl; R4 is C1–C6 alkyl; and Z1 and Z2 are each independently, carbon or nitrogen, with the proviso that when Z1 is carbon, X is oxygen, and R2 is hydrogen, then R3 cannot be hydrogen; b) wherein R5 is C1–C6 alkoxy; and R6 andType: GrantFiled: May 27, 2004Date of Patent: May 16, 2006Assignees: Uniroyal Chemical Company, Inc., Crompton Co./CiieInventors: Gaik-Lean Chee, Mark A. Dekeyser, Kenneth W. Seebold, Jr., Ewa Maria Osika, Walter G. Brouwer, Sheldon B. Park, Hoi Kiong Lai
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Patent number: 6960669Abstract: A method is disclosed for the preparation of benzo[b]thiophenecarbodithioic esters of the formula: wherein R is alkyl, R1 is hydrogen, halogen, or alkyl, R2, R3, R4, and R5 are independently selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, alkylthio, trifluoromethyl, cyano, and aryl, wherein said method comprises reacting an equivalent of an S-thiol ester of the formula: with one-third of an equivalent of P2S5, 2 equivalents of at least one alkali metal carbonate, about 2.5 mole percent of a phase transfer catalyst, and a catalytic amount of water in hot toluene.Type: GrantFiled: September 10, 2003Date of Patent: November 1, 2005Assignee: Crompton Co./CieInventors: Ewa M. Osika, Walter G. Brouwer
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Publication number: 20040266738Abstract: A fungicidally active compound of the formula:Type: ApplicationFiled: May 27, 2004Publication date: December 30, 2004Inventors: Gaik-Lean Chee, Mark A. Dekeyser, Kenneth W. Seebold, Ewa Maria Osika, Walter G. Brouwer, Sheldon B. Park, Hoi Kiong Lai
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Patent number: 5486521Abstract: The present invention is directed to a novel class of pyrimidinyl aryl ketone oximes having excellent herbicidal and insecticidal activity.The novel compounds are represented by the structures I, Ia and Ib shown immediately below.Herbicidal activity is particularly directed against "weed-like" grasses and broadleaf weeds while the insecticidal properties are particularly active against rice planthoppers and aphids.Type: GrantFiled: March 21, 1994Date of Patent: January 23, 1996Assignees: Uniroyal Chemical Company, Inc., Uniroyal Chemical Ltd., LteeInventors: Walter G. Brouwer, Alan W. Dalrymple, Ethel E. Felauer, Paul T. McDonald
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Patent number: 5268389Abstract: A method of inhibiting the growth or replication of viruses of the HIV group is disclosed. Also disclosed are compounds useful in the method and pharmaceutical formulations incorporating such compounds. The method involves the use of compounds having the general formula: ##STR1## wherein the substituent groups are as defined in the specification.Type: GrantFiled: September 26, 1990Date of Patent: December 7, 1993Assignees: Uniroyal Chemical Company, Inc., Uniroyal Chemical Ltd./LteeInventors: William A. Harrison, Ethel E. Felauer, Walter G. Brouwer
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Patent number: 5134145Abstract: This invention is related to a novel class of aryl pyrimidine derivatives having insecticidal, miticidal and nematocidal activity at low concentration. The class of compounds is represented by formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X and Z have the significance given in the description.Pesticidal compositions, methods of controlling pests and methods for preparing the compounds are within the scope of the invention.Type: GrantFiled: November 17, 1989Date of Patent: July 28, 1992Assignees: Uniroyal Chemical Company, Inc., Uniroyal Chemical Ltd./LteeInventors: Walter G. Brouwer, Ethel E. Felauer, Paul T. McDonald
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Patent number: 5134144Abstract: This invention is related to a novel class of 3-arylpyrimidine ethers and thioethers having insecticidal, miticidal and nematocidal activity at low concentration. The class of compounds is represented by formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X and Y have the significance given in the description.Pesticidal compositions, methods of controlling pests and methods for preparing the compounds are within the scope of the invention.Type: GrantFiled: November 20, 1989Date of Patent: July 28, 1992Assignees: Uniroyal Chemical Company, Inc., Uniroyal Chemical Ltd./LteeInventors: Walter G. Brouwer, Ethel E. Felauer, Paul T. McDonald, James A. McGuinness, Anupama Mishra
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Patent number: 4979982Abstract: Compounds having the structure ##STR1## wherein: R is C.sub.1 -C.sub.12 alkyl, linear or branched; or C.sub.3 -C.sub.12 alkenyl;R.sup.1 is C.sub.1 -C.sub.12 alkyl, linear or branched and can form a carbocycle;X is hydrogen or halogen; andY is hydrogen or halogen;are disclosed which have herbicidal activity. Herbicidal compositions comprising the compounds and a carrier are also disclosed, as are methods for controlling the growth orf undesirable plants utilizing the compounds. Methods for the preparation of such compounds are also disclosed.Type: GrantFiled: February 2, 1990Date of Patent: December 25, 1990Assignees: Uniroyal Chemical Company, Inc., Uniroyal Chemical Ltd./LteeInventors: Walter G. Brouwer, Ethel E. Felauer, Allyn R. Bell
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Patent number: 4927451Abstract: A compound having the structural formula ##STR1## where R.sup.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.3 -C.sub.4 alkenyl or trifluoromethyl; R.sup.2 is C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.3 --C.sub.4 alkenyl, C.sub.7 -C.sub.10 aralkyl or C.sub.7 -C.sub.10 haloaralkyl; R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.4 is hydrogen or C.sub.1 -C.sub.2 alkyl; X is halogen; Y is hydrogen, C.sub.1 -C.sub.4 alkyl or halogen; and Z is oxygen or sulfur is disclosed. In addition, a process for forming the compound is set forth. A method for controlling weeds which comprises applying a herbicidally effective amount of the compound recited above is also described. Finally, a composition, useful as a herbicide, including the compound of this invention and a suitable carrier therefor is taught.Type: GrantFiled: December 30, 1988Date of Patent: May 22, 1990Assignees: Uniroyal Chemical Company, Inc., Uniroyal Chemical Ltd/LteeInventors: Walter G. Brouwer, Ethel Ellen Felauer, Allyn Roy Bell
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Patent number: 4822813Abstract: Novel 3-(2-haloalkyl)-1,4-oxathiins or 2-(2-haloalkyl)-1,4-dithiins, useful for regressing or inhibiting the growth of leukemia and tumors in mammals. The compounds have the formula.: ##STR1## wherein R.sub.1 is an alkyl group containing up to 4 carbon atoms, cyclohexyl or phenyl;R.sub.2 is hydrogen or ethyl;R.sub.3 and R.sub.4 are each hydrogen, methyl or ethyl, andwhen either R.sub.3 and R.sub.4 is methyl or ethyl, the other is hydrogen;X is halogen; andY is oxygen or sulfur andwhen Y is sulfur, R.sub.3 and R.sub.4 are both hydrogen.and pharmaceutical compositions comprising said compounds in admixture with a pharmaceutically acceptable substantially non-toxic carrier.Type: GrantFiled: January 21, 1988Date of Patent: April 18, 1989Assignee: Uniroyal Chemical Ltd./Uniroyal Chemical LteeInventors: Walter G. Brouwer, Ethel E. Felauer, Marshal Kulka
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Patent number: 4675044Abstract: Disclosed are derivatives of 3-aryl-5,6-dihydro-1,4,2-oxathiazines and their oxides for use as herbicides, fungicides, plant dessicants and defoliants in agricultural and biocidal applications. Also disclosed are methods of making these compounds.Type: GrantFiled: November 1, 1985Date of Patent: June 23, 1987Assignees: Uniroyal Chemical Company, Inc., Uniroyal Ltd.Inventors: Walter G. Brouwer, Allyn R. Bell, Allen R. Blem, Robert A. Davis
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Patent number: 4664694Abstract: A compound is disclosed having the structural formula ##STR1## where R is hydrogen, chlorine, bromine, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, --CH.sub.2 COOH, --CH.sub.2 COO (C.sub.1 -C.sub.4 alkyl), --CH.sub.2 CONHN (C.sub.1 -C.sub.2 alkyl).sub.2, --CH.sub.2 CONR.sup.4 R.sup.5, --SPS(C.sub.1 -C.sub.4 alkoxy).sub.2 or --SPO(C.sub.1 -C.sub.4 alkoxy).sub.2 (C.sub.1 -C.sub.4 alkylthio).sub.2 ;R.sup.1, R.sup.2 and R.sup.3 are the same or different and are hydrogen, hydroxy, fluorine, chlorine, bromine, iodine, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.6 fluoroalkyl, C.sub.1 -C.sub.6 chloroalkyl, C.sub.1 -C.sub.6 fluoroalkoxy, C.sub.1 -C.sub.6 chloroalkoxy, C.sub.1 -C.sub.6 fluoroalkylthio, C.sub.1 -C.sub.6 chloroalkylthio, C.sub.7 -C.sub.9 aralkyl, phenyl, phenoxy, phenylthio, C.sub.2 -C.sub.5 alkoxycarbonyl, carboxy, nitro or cyano; andR.sup.4 and R.sup.5 are the same or different and are hydrogen or C.sub.1 -C.sub.Type: GrantFiled: April 24, 1985Date of Patent: May 12, 1987Assignees: Uniroyal Chemical Company, Inc., Uniroyal Ltd.Inventors: Walter G. Brouwer, Allen R. Blem
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Patent number: 4569690Abstract: Disclosed are derivatives of 3-aryl-5,6-dihydro-1,4,2-oxathiazines and their oxides for use as herbicides, fungicides, plant dessicants and defoliants in agricultural and biocidal applications. Also disclosed are methods of making these compounds.Type: GrantFiled: September 12, 1983Date of Patent: February 11, 1986Assignees: Uniroyal, Inc., Uniroyal, Ltd.Inventors: Walter G. Brouwer, Allyn R. Bell, Allen R. Blem, Robert A. Davis
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Patent number: 4120861Abstract: Plant growth regulant effects, such as dwarfing, cessation of terminal growth, increased flower set, increased fruit and pod set, fruiting body abortion, twisting and epinastic responses, etc., may be accomplished on crops such as soybeans, cotton, etc., by application of certain 2-(1,3,4-oxadiazol-2-yl) or 2-(2-oxazolyl) or 2-(1,3,4-thiadiazol-2-yl)benzoic acids, salts and esters, having the formula ##STR1## where X is nitrogen or C-R" (R" being hydrogen or methyl), Z is oxygen or sulfur when X is nitrogen, Z is oxygen when X is C-R", R is phenyl or various substituents, and R' is hydrogen or various substituents. An example is 2-(5-phenyl-1,3,4-oxadiazol-2-yl) benzoic acid. The compounds where X is nitrogen and Z is sulfur are new compounds, e.g., 2-(5-phenyl-1,3,4-thiadiazol-2-yl)benzoic acid.Type: GrantFiled: May 2, 1977Date of Patent: October 17, 1978Assignees: Uniroyal, Inc., Uniroyal Ltd.Inventors: Walter G. Brouwer, Edwin J. MacPherson, Ronald B. Ames, Robert W. Neidermyer, Charles E. Crittendon
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Patent number: 4035175Abstract: Plant growth regulant effects, such as dwarfing, cessation of terminal growth, increased flower set, increased fruit and pod set, fruiting body abortion, twisting and epinastic responses, etc., may be accomplished on crops such as soybeans, cotton, etc., by application of certain 2-(1,3,4-oxadiazol-2-yl) or 2-(2-oxazolyl) or 2-(1,3,4-thiadiazol-2-yl)benzoic acids, salts and esters, having the formula ##STR1## where X is nitrogen or C--R" (R" being hydrogen or methyl), Z is oxygen or sulfur when X is nitrogen, Z is oxygen and when X is C--R", R is phenyl or various substituents, and R' is hydrogen or various substituents. An example is 2-(5-phenyl-1,3,4-oxadiazol-2-yl)benzoic acid. The compounds where X is nitrogen and Z is sulfur are new compounds, e.g., 2-(5-phenyl-1,3,4-thiadiazol-2-yl)benzoic acid.Type: GrantFiled: January 12, 1976Date of Patent: July 12, 1977Assignees: Uniroyal Inc., Uniroyal, Ltd.Inventors: Walter G. Brouwer, Edwin J. MacPherson, Ronald B. Ames, Robert W. Neidermyer, Charles E. Crittendon
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Patent number: 3964896Abstract: New 2-(1,3,4-oxadiazole-2-yl) benzoic acids and salts and esters thereof, as well as certain 2-(2-oxazolyl) benzoic acids, salts and esters, having the formula: ##SPC1##Where X is nitrogen or C-R" (R" being hydrogen or methyl), R is phenyl or various substituents, and R' and the Y's are hydrogen or various substituents, are effective preemergence or postemergence herbicides, on various crops. The chemicals act selectively and are useful against purple nutsedge and in cranberry. Oxadiazoles of the invention may be made by reacting a benzhydrazide with phthalic anhydride to form a hydrazide which is cyclized by removal of the elements of water, using as a catalyst fuming sulfuric acid or dimethylformamide-sulfur trioxide complex.Type: GrantFiled: February 5, 1975Date of Patent: June 22, 1976Assignee: Uniroyal, Inc.Inventors: Walter G. Brouwer, Edwin J. MacPherson, Ronald B. Ames, Robert W. Neidermyer
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Patent number: 3947263Abstract: Plant growth regulant effects, such as dwarfing, cessation of terminal growth, increased flower set, increased fruit and pod set, fruiting body abortion, twisting and epinastic responses, etc., may be accomplished on crops such as soybeans, cotton, etc., by application of certain 2-(1,3,4-oxadiazol-2-yl) or 2-(2-oxazolyl) or 2-(1,3,4-thiadiazol-2-yl)benzoic acids, salts and esters, having the formula ##SPC1##Where X is nitrogen or C--R" (R" being hydrogen or methyl), Z is oxygen or sulfur when X is nitrogen, Z is oxygen when X is C--R", R is phenyl or various substituents, and R' is hydrogen or various substituents. An example is 2-(5-phenyl-1,3,4-oxadiazol-2-yl)benzoic acid. The compounds where X is nitrogen and Z is sulfur are new compounds, e.g., 2-(5-phenyl-1,3,4-thiadiazol-2-yl)benzoic acid.Type: GrantFiled: July 29, 1974Date of Patent: March 30, 1976Assignees: Uniroyal, Inc., Uniroyal Ltd.Inventors: Walter G. Brouwer, Edwin J. MacPherson, Ronald B. Ames, Robert W. Neidermyer, Charles E. Crittendon