Patents by Inventor Walter G. M. Schmidt

Walter G. M. Schmidt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition for introducing nucleic acid complexes into higher eucaryotic cells
    Patent number: 6274322
    Abstract: A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, which may be conjugated. The endosomolytic agent, which is optionally part of the nucleic acid complex, is internalized into the cells together with the complex and releases the contents of the endosomes into the cytoplasm, thereby increasing the gene transfer capacity. Pharmaceutical preparations, transfection kits and methods for introducing nucleic acid into higher eucaryotic cells by treating the cells with the composition are also disclosed.
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: August 14, 2001
    Assignees: Boehringer Ingelheim International GmbH, Genentech, Inc., The University of North Carolina at Chapel Hill
    Inventors: David T. Curiel, Max L. Birnstiel, Matthew Cotten, Ernst Wagner, Kurt Zatloukal, Christian Plank, Berndt Oberhauser, Walter G. M. Schmidt
  • Composition for introducing nucleic acid complexes into higher eucaryotic cells
    Patent number: 6077663
    Abstract: A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, which may be conjugated. The endosomolytic agent, which is optionally part of the nucleic acid complex, is internalized into the cells together with the complex and releases the contents of the endosomes into the cytoplasm, thereby increasing the gene transfer capacity. Pharmaceutical preparations, transfection kits and methods for introducing nucleic acid into higher eucaryotic cells by treating the cells with the composition are also disclosed.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: June 20, 2000
    Assignees: Boehringer Ingelheim International GmbH, Genentech, Inc., The University of North Carolina at Chapel Hill
    Inventors: David T. Curiel, Max L. Birnstiel, Matthew Cotten, Ernst Wagner, Kurt Zatloukal, Christian Plank, Berndt Oberhauser, Walter G.M. Schmidt
  • Composition for introducing nucleic acid complexes into higher eucaryotic cells
    Patent number: 6022735
    Abstract: A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, which may be conjugated. The endosomolytic agent, which is optionally part of the nucleic acid complex, is internalized into the cells together with the complex and releases the contents of the endosomes into the cytoplasm, thereby increasing the gene transfer capacity. Pharmaceutical preparations, transfection kits and methods for introducing nucleic acid into higher eucaryotic cells by treating the cells with the composition are also disclosed.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: February 8, 2000
    Assignees: Boehringer Ingelheim International GmbH, Genetech, Inc., The University of North Carolina at Chapel Hill
    Inventors: David T. Curiel, Max L. Birnstiel, Matthew Cotten, Ernst Wagner, Kurt Zatloukal, Christian Plank, Berndt Oberhauser, Walter G. M. Schmidt
  • Composition comprising an endosomolytic agent for introducing nucleic acid complexes into higher eucaryotic cells
    Patent number: 5981273
    Abstract: A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, which may be conjugated. The endosomolytic agent, which is optionally part of the nucleic acid complex, is internalized into the cells together with the complex and releases the contents of the endosomes into the cytoplasm, thereby increasing the gene transfer capacity. Pharmaceutical preparations, transfection kits and methods for introducing nucleic acid into higher eucaryotic cells by treating the cells with the composition are also disclosed.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: November 9, 1999
    Assignees: Boehringer Ingelheim Int'l. GmbH, Genentech, Inc., The University of North Carolina
    Inventors: David T. Curiel, Max L. Birnstiel, Matthew Cotten, Ernst Wagner, Kurt Zatloukal, Christian Plank, Berndt Oberhauser, Walter G. M. Schmidt
  • Composition for introducing nucleic acid complexes into higher eucaryotic cells
    Patent number: 5547932
    Abstract: A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, which may be conjugated. The endosomolytic agent, which is optionally part of the nucleic acid complex, is internalized into the cells together with the complex and releases the contents of the endosomes into the cytoplasm, thereby increasing the gene transfer capacity. Pharmaceutical preparations, transfection kits and methods for introducing nucleic acid into higher eucaryotic cells by treating the cells with the composition are also disclosed.
    Type: Grant
    Filed: September 23, 1992
    Date of Patent: August 20, 1996
    Assignees: Boehringer Ingelheim International GmbH, Genentech, Inc.
    Inventors: David T. Curiel, Max L. Birnstiel, Matthew Cotten, Ernst Wagner, Kurt Zatloukal, Christian Plank, Berndt Oberhauser, Walter G. M. Schmidt