Patents by Inventor Walter Gilbert

Walter Gilbert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptides involved in the pathogenesis of HIV infection
    Patent number: 5017688
    Abstract: This invention relates to peptides involved in the pathogenesis of human immunodeficiency virus ("HIV"). More particularly, this invention relates to peptides from the env region of the HIV genome and the use of such peptides in methods and compositions for preventing, treating, or detecting acquired immune deficiency syndrome ("AIDS") infection.
    Type: Grant
    Filed: October 30, 1989
    Date of Patent: May 21, 1991
    Assignee: Biogen, Inc.
    Inventors: Walter Gilbert, Richard A. Fisher, Vicki L. Sato, Kuzhalmannam L. Ramachandran
  • Peptides involved in the pathogenesis of HIV infection
    Patent number: 4943627
    Abstract: This invention relates to peptides involved in the pathogenesis of human immunodeficiency virus ("HIV"). More particularly, this invention relates to peptides from the env region of the HIV genome and the use of such peptides in methods and compositions for preventing, treating, or detecting acquired immune deficiency syndrome ("AIDS") infection.
    Type: Grant
    Filed: August 16, 1988
    Date of Patent: July 24, 1990
    Assignee: Biogen, Inc.
    Inventors: Walter Gilbert, Richard A. Fisher, Vicki L. Sato, Johann J. Leban
  • Recombinant DNA molecule
    Patent number: 4565785
    Abstract: A plasmid or phage gene for a periplasmic or extracellular bacterial protein is cleaved, a double-stranded DNA sequence coding for a selected protein or portion thereof from a eukaryotic cell such as insulin is inserted in that cleaved gene by recombinant DNA techniques and used to transform a bacterium, and the excreted selected protein is collected.
    Type: Grant
    Filed: August 1, 1983
    Date of Patent: January 21, 1986
    Assignee: The President and Fellows of Harvard College
    Inventors: Walter Gilbert, Stephanie A. Broome, Lydia J. Villa-Komaroff, Argiris A. Efstratiadis
  • Protein synthesis
    Patent number: 4411994
    Abstract: A plasmid or phage gene for a periplasmic or extracellular bacterial protein is cleaved, a double-stranded DNA sequence coding for a selected protein or portion thereof from a eukaryotic cell such as insulin is inserted in that cleaved gene by recombinant DNA techniques and used to transform a bacterium, and the excreted selected protein is collected.
    Type: Grant
    Filed: June 8, 1978
    Date of Patent: October 25, 1983
    Assignee: The President and Fellows of Harvard College
    Inventors: Walter Gilbert, Stephanie A. Broome, Lydia J. Villa-Komaroff, Argiris A. Efstratiadis
  • Mature protein synthesis
    Patent number: 4338397
    Abstract: A method is provided for synthesizing within a bacterial host, and secreting through the membrane of the host, a selected mature protein or polypeptide. The method involves:(a) cleaving a cloning vehicle to form a cleavage site after a promoter of either (1) a bacterial or phage gene within the cloning vehicle or (2) a DNA fragment of the bacterial or phage gene;(b) forming a hybrid gene by inserting into the cleavage site a non-bacterial DNA fragment which codes for precursor of the selected protein or polypeptide, including the signal sequence of the selected protein or polypeptide;(c) transforming the host with the cloning vehicle; and then(d) culturing the transformed host to secrete the selected protein or polypeptide.By this method, mature proteins or polypeptides can be produced, free of signal sequences or other chemical substituents, such as an f-met, on the proteins or polypeptides.
    Type: Grant
    Filed: April 11, 1980
    Date of Patent: July 6, 1982
    Assignee: President and Fellows of Harvard College
    Inventors: Walter Gilbert, Karen Talmadge
  • Creeper
    Patent number: D321578
    Type: Grant
    Filed: September 8, 1989
    Date of Patent: November 12, 1991
    Inventor: Walter Gilbert
  • Automobile mechanic's creeper
    Patent number: D330619
    Type: Grant
    Filed: June 24, 1991
    Date of Patent: October 27, 1992
    Inventors: Lavon Gilbert, Walter Gilbert