Patents by Inventor Walter Giust

Walter Giust has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for treprostinil salt preparation
    Patent number: 9550716
    Abstract: Disclosed is a process for preparing a treprostinil salt. The process involves the step of dissolving treprostinil in a water-miscible organic solvent to form a treprostinil solution. The treprostinil solution is reacted with an aqueous basic solution containing an alkali metal cation to form treprostinil salt. Allowing crystallization of the treprostinil salt to take place, and then collecting the treprostinil salt formed.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: January 24, 2017
    Assignee: EON LABS, INC.
    Inventors: Walter Giust, Fabio Souza, Jan Oudenes, Boris Gorin, Elena Bejan
  • PROCESS FOR TREPROSTINIL SALT PREPARATION
    Publication number: 20140024856
    Abstract: Disclosed is a process for preparing a treprostinil salt. The process involves the step of dissolving treprostinil in a water-miscible organic solvent to form a treprostinil solution. The treprostinil solution is reacted with an aqueous basic solution containing an alkali metal cation to form treprostinil salt. Allowing crystallization of the treprostinil salt to take place, and then collecting the treprostinil salt formed.
    Type: Application
    Filed: December 22, 2011
    Publication date: January 23, 2014
    Applicant: ALPHORA RESEARCH INC.
    Inventors: Walter Giust, Fabio Souza, Jan Oudenes, Boris Gorin, Elena Bejan
  • Synthesis Of Treprostinil And Intermediates Useful Therein
    Publication number: 20130331593
    Abstract: Treprostinil is prepared by a process which involves Pauson-Khan cyclization of an an alkene-substituted, alkyne-substituted benzene corresponding to formula: (I) where PMB represents para-methoxy benzyl protecting group and R1 and R2 are alcohol protecting groups. Following cyclization, the resulting compound can be subjected to several chemical trans-formations followed by alkylation, hydrolysis and salt formation to yield treprostinil sodium. The use of para-methoxybenzyl group as the phenolic protecting group confers several process advantages that result in simplified purification of the final product and improved yields.
    Type: Application
    Filed: July 22, 2011
    Publication date: December 12, 2013
    Applicant: ALPHORA RESEARCH INC.
    Inventors: Graham Mcgowan, Walter Giust, Danielle Marie Di Donato, Teng-Ko Ngooi, Jan Oudenes