Patents by Inventor Walter Hubsch
Walter Hubsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11572357Abstract: The present invention covers new quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: May 7, 2019Date of Patent: February 7, 2023Assignee: Bayer Animal Health GmbHInventors: Walter Hübsch, Nils Griebenow, Hans-Georg Schwarz, Daniel Kulke, Claudia Böhm, Kirsten Börngen, Bernd Alig, Wei Zhuang, Iring Heisler, Thomas Ilg, Johannes Köbberling, Adeline Köhler, Niels Lindner, Ulrich Görgens, Claudia Welz, Maike Hink
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Patent number: 11505545Abstract: The present invention covers new quinoline compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: October 30, 2020Date of Patent: November 22, 2022Assignee: Bayer Animal Health GmbHInventors: Walter Hübsch, Johannes Köbberling, Adeline Köhler, Hans-Georg Schwarz, Daniel Kulke, Claudia Welz, Thomas Ilg, Kirsten Börngen, Wei Zhuang, Nils Griebnow, Claudia Böhm, Niels Lindner, Maike Hink, Ulrich Görgens
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Patent number: 11485733Abstract: The present invention covers azaquinoline compounds of general formula (I), with A being (A1) or (A2), and in which T, R1, R2, R3, R4, R5, R6 and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: June 22, 2018Date of Patent: November 1, 2022Assignee: BAYER ANIMAL HEALTH GMBHInventors: Nils Griebenow, Wei Zhuang, Adeline Köhler, Daniel Kulke, Claudia Böhm, Kirsten Börngen, Thomas Ilg, Hans-Georg Schwarz, Werner Hallenbach, Ulrich Görgens, Walter Hübsch, Bernd Alig, Iring Heisler, Isa Jana Irina Janssen
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Publication number: 20220153745Abstract: This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R1 is hydrogen, chloro, methyl or methoxy, R2 is hydrogen or methoxy, with the proviso that at least one of R1 and R2 is other than hydrogen, G1 represents chloro, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group —CH2—OR3, —CH2—NR4R5 or —C(=0)-NR4R6, and G2 represents chloro, cyano, (C1-C4)-alkyl, or the group —CR8AR8B—OH, —CH2—NR9R10, —C(=0)—NR11R12 or —CH2—OR15, having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.Type: ApplicationFiled: November 1, 2021Publication date: May 19, 2022Inventors: Dirk BROHM, Melanie HEROULT, Marie-Pierre COLLIN, Walter HÜBSCH, Mario LOBELL, Klemens LUSTIG, Sylvia GRÜNEWALD, Ulf BÖMER, Verena VÖHRINGER
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Patent number: 11254661Abstract: The present invention covers quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: July 30, 2018Date of Patent: February 22, 2022Inventors: Nils Griebenow, Wei Zhuang, Daniel Kulke, Claudia Böhm, Hans-Georg Schwarz, Walter Hübsch, Thomas Ilg
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Patent number: 11130768Abstract: The present invention covers bicyclic pyrazole compounds of general formula (I): in which G, A, R1, R2, R3, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: April 23, 2018Date of Patent: September 28, 2021Assignee: Bayer Animal Health GmbHInventors: Nils Griebenow, Wei Zhuang, Daniel Kulke, Adeline Köhler, Thomas Ilg, Claudia Welz, Hans-Georg Schwarz, Ulrich Görgens, Walter Hübsch, Johannes Köbberling
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Publication number: 20210139468Abstract: The present invention covers new quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: May 7, 2019Publication date: May 13, 2021Inventors: Walter HÜBSCH, Nils GRIEBENOW, Hans-Georg SCHWARZ, Daniel KULKE, Claudia BÖHM, Kirsten BÖRNGEN, Bernd ALIG, Wei ZHUANG, Iring HEISLER, Thomas ILG, Johannes KÖBBERLING, Adeline KÖHLER, Niels LINDNER, Ulrich GÖRGENS, Claudia WELZ, Maike HINK
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Publication number: 20210115026Abstract: The present invention covers new quinoline compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: October 30, 2020Publication date: April 22, 2021Inventors: Walter HÜBSCH, Johannes KÖBBERLING, Adeline KÖHLER, Hans-Georg SCHWARZ, Daniel KULKE, Claudia WELZ, Thomas ILG, Kirsten BÖRNGEN, Wei ZHUANG, Nils GRIEBNOW, Claudia BÖHM, Niels LINDNER, Maike HINK, Ulrich GÖRGENS
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Patent number: 10889573Abstract: The present invention covers new quinoline compounds of general formula (I) in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: November 6, 2017Date of Patent: January 12, 2021Assignee: Bayer Animal Health GMBHInventors: Walter Hübsch, Johannes Köbberling, Adeline Köhler, Hans-Georg Schwarz, Daniel Kulke, Claudia Welz, Thomas Ilg, Kirsten Börngen, Wei Zhuang, Nils Griebenow, Claudia Böhm, Niels Lindner, Maike Hink, Ulrich Görgens
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Publication number: 20200377486Abstract: The present invention covers quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: July 30, 2018Publication date: December 3, 2020Applicant: Bayer Animal Health GMBHInventors: Nils GRIEBENOW, Wei ZHUANG, Daniel KULKE, Claudia BÖHM, Hans-Georg SCHWARZ, Walter HÜBSCH, Thomas ILG
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Publication number: 20200190111Abstract: The present invention covers bicyclic pyrazole compounds of general formula (I): in which G, A, R1, R2, R3, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: April 23, 2018Publication date: June 18, 2020Applicant: Bayer Animal Health GMBHInventors: Nils GRIEBENOW, Wei ZHUANG, Daniel KULKE, Adeline KÖHLER, Thomas ILG, Claudia WELZ, Hans-Georg SCHWARZ, Ulrich GÖRGENS, Walter HÜBSCH, Johannes KÖBBERLING
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Publication number: 20200131175Abstract: The present invention covers azaquinoline compounds of general formula (I), with A being (A1) or (A2), and in which T, R1, R2, R3, R4, R5, R6 and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: June 22, 2018Publication date: April 30, 2020Applicant: BAYER ANIMAL HEALTH GMBHInventors: Nils GRIEBENOW, Wei ZHUANG, Adeline KÖHLER, Daniel KULKE, Claudia BÖHM, Kirsten BÖRNGEN, Thomas ILG, Hans-Georg SCHWARZ, Werner HALLENBACH, Ulrich GÖRGENS, Walter HÜBSCH, Bernd ALIG, Iring HEISLER, Isa Jana Irina JANSSEN
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Patent number: 10604525Abstract: The present invention covers Pyrazolopyrimidine compounds of general formula (I), in which n, o, X, Y, R, Q, R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: April 10, 2017Date of Patent: March 31, 2020Assignee: BAYAL ANIMAL HEALTH GMBHInventors: Adeline Köhler, Claudia Welz, Kirsten Börngen, Daniel Kulke, Thomas Ilg, Johannes Köbberling, Walter Hübsch, Hans-Georg Schwarz, Ulrich Görgens, Ulrich Ebbinghaus-Kintscher, Maike Hink, Dirk Nennstiel, Klaus Raming, Martin Adamczewski, Claudia Böhm, Nils Griebenow, Wei Zhuang
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Publication number: 20200024264Abstract: The present invention covers new quinoline compounds of general formula (I) in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: November 6, 2017Publication date: January 23, 2020Applicant: Bayer Animal Health GMBHInventors: Walter HÜBSCH, Johannes KÖBBERLING, Adeline KÖHLER, Hans-Georg SCHWARZ, Daniel KULKE, Claudia WELZ, Thomas ILG, Kirsten BÖRNGEN, Wei ZHUANG, Nils GRIEBENOW, Claudia BÖHM, Niels LINDNER, Maike HINK, Ulrich GÖRGENS
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Publication number: 20190071447Abstract: The present invention covers Pyrazolopyrimidine compounds of general formula (I), in which n, o, X, Y, R, Q, R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: April 10, 2017Publication date: March 7, 2019Applicant: BAYER ANIMAL HEALTH GMBHInventors: Adeline KÖHLER, Claudia WELZ, Kirsten BÖRNGEN, Daniel KULKE, Thomas ILG, Johannes KÖBBERLING, Walter HÜBSCH, Hans-Georg SCHWARZ, Ulrich GÖRGENS, Ulrich EBBINGHAUS-KINTSCHER, Maike HINK, Dirk NENNSTIEL, Klaus RAMING, Martin ADAMCZEWSKI, Claudia BÖHM
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Publication number: 20190016724Abstract: This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R1 is hydrogen, chloro, methyl or methoxy, R2 is hydrogen or methoxy, with the proviso that at least one of R1 and R2 is other than hydrogen, G1 represents chloro, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group —CH2—OR3, —CH2—NR4R5 or —C(?O)-NR4R6, and G2 represents chloro, cyano, (C1-C4)-alkyl, or the group —CR8AR8B—OH, —CH2—NR9R10, —C(?O)—NR11R12 or —CH2—OR15, having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.Type: ApplicationFiled: February 20, 2018Publication date: January 17, 2019Inventors: Dirk BROHM, Melanie HEROULT, Marie-Pierre COLLIN, Walter HÜBSCH, Mario LOBELL, Klemens LUSTIG, Sylvia GRÜNEWALD, Ulf BÖMER, Verena VÖHRINGER
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Patent number: 10053428Abstract: The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.Type: GrantFiled: May 19, 2017Date of Patent: August 21, 2018Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Michael Hahn, Markus Follmann, Eva-Maria Becker, Johannes-Peter Stasch, Joerg Keldenich, Martina Delbeck, Hanna Tinel, Frank Wunder, Joachim Mittendorf, Ildiko Terebesi, Dieter Lang, René Martin, Walter Hübsch
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Patent number: 9936699Abstract: The invention relates inter alia to halogen-substituted compounds of the general formula (I) in which the substituents A1, R1-R3 and Z1-Z3 have the meanings given in the description. Also described are processes for preparing the compounds of the formula (I) and possible intermediates for the preparation of these compounds. The compounds according to the invention are particularly suitable for controlling insects, arachnids and nematodes in agriculture and ectoparasites in veterinary medicine.Type: GrantFiled: August 5, 2015Date of Patent: April 10, 2018Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFTInventors: Michael Maue, Tobias Harschneck, Julia Johanna Hahn, Thomas Bretschneider, Anne Decor, Reiner Fischer, Werner Hallenbach, Hans-Georg Schwarz, Robert Velten, Niels Böhnke, Olga Malsam, Ulrich Görgens, Sebastian Horstmann, Klaus Raming, Johannes Köbberling, Walter Hübsch
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Publication number: 20170260139Abstract: The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.Type: ApplicationFiled: May 19, 2017Publication date: September 14, 2017Applicant: BAYER PHARMA AKTIENGESELLSCHAFTInventors: MICHAEL HAHN, MARKUS FOLLMANN, EVA-MARIA BECKER, JOHANNES-PETER STASCH, JOERG KELDENICH, MARTINA DELBECK, HANNA TINEL, FRANK WUNDER, JOACHIM MITTENDORF, ILDIKO TEREBESI, DIETER LANG, RENÉ MARTIN, WALTER HÜBSCH
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Publication number: 20170233413Abstract: The present application relates to novel substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.Type: ApplicationFiled: August 25, 2015Publication date: August 17, 2017Applicant: Bayer Pharma AktiengesellschaftInventors: Walter HÜBSCH, Alexandros VAKALOPOULOS, Markus FOLLMANN, Gaelle VALOT, Johannes-Peter STASCH, Damian BROCKSCHNIEDER, Tobias MARQUARDT, Frank WUNDER, Adrian TERSTEEGEN, Lisa DIETZ, Dieter LANG, Niels LINDNER