Abstract: An alcoholic, aqueous gel-like phospholipid composition is disclosed which contains, as alcohols, ethanol, 1-propanol or 2-propanol, which is characterized in that this composition is a liposomal gel composed of 15.00 to 30.00 parts by weight of a phospholipid concentrate, 14.00 to 20.00 parts by weight of alcohol and 50 to 71.00 parts by weight of an aqueous solution as the remainder. The use of this phospholipid composition for the preparation of liposomal solutions by dilution with a solution and topical preparations which contain these solutions are additionally disclosed.

Abstract: An alcoholic, aqueous gel-like phospholipid composition is disclosed which contains, as alcohols, ethanol, 1-propanol or 2-propanol, which is characterized in that this composition is a liposomal gel composed of 15.00 to 30.00 parts by weight of a phospholipid concentrate, 14.00 to 20.00 parts by weight of alcohol and 50 to 71.00 parts by weight of an aqueous solution as the remainder. The use of this phospholipid composition for the preparation of liposomal solutions by dilution with a solution and topical preparations which contain these solutions are additionally disclosed.

Abstract: Novel pyridone-acetic acid derivative, viz. 3,5-dichloro-4-pyridone-1-acetic acid (I) is used as an intermediate in the production of certain cephem derivatives having anti-bacterial activity against gram-negative and gram-positive bacteria. The acid (I) is prepared by methods generally known in the art, e.g. by reacting 3,5-dichloro-4-pyridone with chloracetic acid or bromoacetic acid.

Abstract: Cephem derivatives of the formula ##STR1## wherein Z is 1,4-dihydro-4-oxo-1-pyridyl or the corresponding group substituted by one or more of alkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, OH, F, Cl, Br, I, NO.sub.2 and NH.sub.2 ; and R is H, --OCOCH.sub.3 or -S-Het, wherein Het is 3-methyl-1,2,4-thiadiazolyl-5, 5-methyl-1,3,4-oxadiazolyl-2, 5-hydroxymethyl-1,3,4-oxadiazolyl-2, 5-methyl-1,3,4-thiadiazolyl-2, 5-hydroxymethyl-1,3,4-thiadiazolyl-2, tetrazolyl-5, 1-methyltetrazolyl-5, 1,2,3-triazolyl-4, 4-methyl-oxazolyl-2 or 1-oxidopyridinio-2, and the readily cleavable esters thereof and the physiologically acceptable salts thereof, possess anti-bacterial activity and can be prepared by reacting a 3-CH.sub.2 R-7-amino-3-cephem-4-carboxylic acid or a functional derivative thereof with a pyridone acetic acid of the formula Z-CH.sub.2 -COOH or a functional derivative thereof.

Abstract: 7-Methoxy-6-thiatetracyclines of the formula ##SPC1##Wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are H or alkyl of 1 to 4 carbon atoms, and the physiologically acceptable acid addition salts thereof.