Abstract: The invention provides isolated Pre-Ligand Assembly Domain (PLAD) polypeptides which inhibit multimerization of a receptor complex comprising an IL-17R family member. Related PLAD-binding polypeptides, chimeric proteins, conjugates, nucleic acids, vectors, host cells, and methods are provided herein.

Abstract: The invention provides isolated Pre-Ligand Assembly Domain (PLAD) polypeptides comprising an amino acid sequence of a domain (e.g., a Fibronectin Ill-like domain) of an IL-17 Receptor (IL-17R) family member, wherein the PLAD polypeptide inhibits multimerization of a receptor complex comprising an IL-17R family member. Also provided are isolated PLAD-binding polypeptides, e.g., antibodies and avimers, which specifically bind to a PLAD polypeptide described herein. Related chimeric proteins, conjugates, nucleic acids, vectors, and host cells are provided herein. Further provided are methods of treating an inflammatory or autoimmune disease, methods of inhibiting IL-17-mediated signal transduction, methods of inhibiting IL-17 ligand binding, methods of inhibiting multimerization of IL-17R complexes, and methods of inhibiting the production of at least one cytokine, chemokine, matrix metalloproteinase, or other molecule associated with IL-17 signal transduction are provided.

Abstract: The invention provides isolated Pre-Ligand Assembly Domain (PLAD) polypeptides comprising an amino acid sequence of a domain (e.g., a Fibronectin Ill-like domain) of an IL-17 Receptor (IL-17R) family member, wherein the PLAD polypeptide inhibits multimerization of a receptor complex comprising an IL-17R family member. Also provided are isolated PLAD-binding polypeptides, e.g., antibodies and avimers, which specifically bind to a PLAD polypeptide described herein. Related chimeric proteins, conjugates, nucleic acids, vectors, and host cells are provided herein. Further provided are methods of treating an inflammatory or autoimmune disease, methods of inhibiting IL-17-mediated signal transduction, methods of inhibiting IL-17 ligand binding, methods of inhibiting multimerization of IL-17R complexes, and methods of inhibiting the production of at least one cytokine, chemokine, matrix metalloproteinase, or other molecule associated with IL-17 signal transduction are provided.

Abstract: A method is disclosed in a number of embodiments, which use an identifier to control and limit the operation of a command and/or security code to one or more subdomains, such as directories, of a file structure. In one embodiment, the identifier is allocated to the command or to the security code. In another embodiment, the identifier is allocated to the subdomain. The security code includes a cryptographic key or a password.

Abstract: The invention relates to a procedure for the certification of cryptographic keys for use in chipcards. In this procedure, a certification key and a certificate are transferred to the chipcard. The first part of the certificate includes the cryptographic key and the second part of the certificate includes a digital signature of the first part of the certificate. The digital certificate is subsequently checked by means of the certification key on the chipcard.

Abstract: A method and a system are proposed for increasing the data integrity on smartcards. In accordance with the invention a sequence of write processes on a smartcard is defined as a unit for which the integrity of the data to be written is ensured. The write process may involve the writing of data to one or more files. The data of an integrity unit i.e. a unit of data for which the integrity is to be ensured is preferably written to shadow memory. The method in accordance with the invention decreases considerably the likelihood that data will be corrupted through an error in writing the data on the smartcard. Data can be restored or completed through the interface of read-write units. The method in accordance with the invention can serve as a basis for maintaining data files external to the smartcard consistent with data on the smartcard.

Abstract: The invention relates to communication with smart cards. Communication of any desired device with a smart card is effected by sending a message to the smart card through the device, receipt of the message by the smart card and processing of the message in accordance with one of the processes in accordance with the invention. A message arriving in a smart card is written and stored by a processor unit in a writable, non-volatile memory, such as an EEPROM, before the message is checked for authorization on the smart card by the processor unit.