Patents by Inventor Walter Hunziker
Walter Hunziker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11820981Abstract: The invention is a method for treating a heart disease, in particular acute myocardial infarction (AMI) in a subject comprising the step of administering to the subject a Tjp1 inhibitor, wherein administration of said Tjp1 inhibitor promotes cardiomyocyte proliferation. The invention further includes use of Tjp1 inhibitor in the manufacture of a medicament for a heart disease, a patch, and a nucleic acid encoding a Tjp1 inhibitor. In a particular embodiment, the Tjp1 inhibitor is a nucleic acid, i.e. an siRNA or shRNA of Tjp1. The invention also includes administration of said Tjp1 inhibitor in combination with Neuregulin-1 (NRG1), Fibroblast growth factor (FGF), Vascular endothelial growth factor (VEGF) or Follistatin-like 1 (Fst1) and wherein said inhibitor is delivered in an adeno-associated virus of serotype 9 (AAV 9).Type: GrantFiled: September 14, 2017Date of Patent: November 21, 2023Assignees: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, NATIONAL UNIVERSITY OF SINGAPOREInventors: Walter Hunziker, Jianliang Xu, Jiong-Wei Wang, P. Jaya Kausalya
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Patent number: 11583612Abstract: There is provided a material comprising a multi-block thermogelling polymer, said multi-block thermogelling polymer comprising a hydrophilic polymer block; a thermosensitive polymer block; and a hydrophobic polymer block, wherein the hydrophilic polymer block, the thermosensitive polymer block and the hydrophobic polymer block are chemically coupled together by at least one of urethane/carbamate, carbonate, ester linkages or combinations thereof, and wherein the material is suitable for use as a vitreous substitute. Also provided are a method of preparing said material and a synthetic vitreous humour or part thereof comprising said material.Type: GrantFiled: February 28, 2020Date of Patent: February 21, 2023Assignees: Agency for Science, Technology and Research, National University Hospital (Singapore) Pte Ltd, National University of Singapore, Singapore Health Services Pte LtdInventors: Xian Jun Loh, Xinyi Su, Zengping Liu, Gopal Lingam, Veluchamy Amutha Barathi, Walter Hunziker
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Patent number: 11495956Abstract: A trip apparatus has a power terminal, an actuator, a rectifier coupled to the power terminal, a selector, and a processor, the actuator having a pusher member and a coil, the pusher member movable between a first position that does not actuate an actuator interface of a connected circuit breaker and a second position that actuates the actuator interface. The processor has a first input, a second input, and an output, the first input of the processor is coupled to the output of the rectifier, the second input of the processor coupled to an output of the selector, and the output of the processor coupled to the actuator. The processor determines a threshold based on a select signal received at the second input of the processor, and compares a voltage at the first input of the processor to the threshold. The processor controls the coil to selectively control the pusher member in the first or second position based on the comparison of the voltage at the first input of the processor to the threshold.Type: GrantFiled: August 24, 2021Date of Patent: November 8, 2022Assignee: Rockwell Automation Technologies, Inc.Inventors: Thomas Strebel Marzano, Walter Hunziker
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Publication number: 20200276357Abstract: There is provided a material comprising a multi-block thermogelling polymer, said multi-block thermogelling polymer comprising a hydrophilic polymer block; a thermosensitive polymer block; and a hydrophobic polymer block, wherein the hydrophilic polymer block, the thermosensitive polymer block and the hydrophobic polymer block are chemically coupled together by at least one of urethane/carbamate, carbonate, ester linkages or combinations thereof, and wherein the material is suitable for use as a vitreous substitute. Also provided are a method of preparing said material and a synthetic vitreous humour or part thereof comprising said material.Type: ApplicationFiled: February 28, 2020Publication date: September 3, 2020Inventors: Xian Jun LOH, Xinyi SU, Zengping LIU, Gopal LINGAM, Amutha Veluchamy BARATHI, Walter HUNZIKER
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Publication number: 20190256846Abstract: The invention is a method for treating a heart disease, in particular acute myocardial infarction (AMI) in a subject comprising the step of administering to the subject a Tjp1 inhibitor, wherein administration of said Tjp1 inhibitor promotes cardiomyocyte proliferation. The invention further includes use of Tjp1 inhibitor in the manufacture of a medicament for a heart disease, a patch, and a nucleic acid encoding a Tjp1 inhibitor. In a particular embodiment, the Tjp1 inhibitor is a nucleic acid, i.e. an siRNA or shRNA of Tjp1. The invention also includes administration of said Tjp1 inhibitor in combination with Neuregulin-1 (NRG1), Fibroblast growth factor (FGF), Vascular endothelial growth factor (VEGF) or Follistatin-like 1 (Fst1) and wherein said inhibitor is delivered in an adeno-associated virus of serotype 9 (AAV 9).Type: ApplicationFiled: September 14, 2017Publication date: August 22, 2019Inventors: Walter HUNZIKER, Jianliang XU, Jiong-Wei WANG, P. Jaya KAUSALYA
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Patent number: 9963704Abstract: There is provided a method of identifying candidate agents capable of modulating interaction between a first polypeptide and a second polypeptide, wherein the first polypeptide is ZO-2/TJP2 or a functional variant thereof and the second polypeptide is a Snail zinc finger transcription factor family member or a functional variant thereof.Type: GrantFiled: February 28, 2013Date of Patent: May 8, 2018Assignee: Agency for Science, Technology and ResearchInventors: Walter Hunziker, Choon Peng Goh
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Publication number: 20170081723Abstract: The present invention relates to a method for determining or making of a prognosis if a patient has cancer or is at an increased risk of having cancer, the method comprising testing for the presence of one or more cancer-associated fusion genes, or proteins derived thereof, in a sample obtained from a patient. More specifically, the present invention relates to fusion genes CLEC16A-EMP2, SNX2-PRDM6, MLL3-PRKAG2, DUS2L-PSKH1 and CLDN18-ARHGAP26 in gastric cancer. Use of the method and a kit when used in the method are also provided.Type: ApplicationFiled: March 23, 2015Publication date: March 23, 2017Applicants: Agency for Science, Technology and Research, National University of SingaporeInventors: Axel Hillmer, Yijun Ruan, Fei Yao, Patrick Tan, Khay Guan Yeoh, Walter Hunziker, Audrey S M Teo, Yee Yen Sia
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Publication number: 20150250854Abstract: The present invention relates to a novel gene encoding a protein termed voltage gated calcium channels ? subunit anchoring regulator protein (VDCC BARP) or a peptide fragments thereof. The present invention also relates to the use of VDCC BARP in modulation of voltage gated calcium channels via altering the concentration of VDCC BARP or a peptide fragments thereof.Type: ApplicationFiled: March 20, 2015Publication date: September 10, 2015Applicant: Agency for Science, Technology and ResearchInventors: Pascal Beguin, Walter Hunziker
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Patent number: 9018000Abstract: The present invention relates to a novel gene encoding a protein termed voltage gated calcium channels ? subunit anchoring regulator protein (VDCC BARP) or a peptide fragments thereof. The present invention also relates to the use of VDCC BARP in Modulation of voltage gated calcium channels via altering the concentration of VDCC BARP or a peptide fragments thereof.Type: GrantFiled: June 18, 2008Date of Patent: April 28, 2015Assignee: Agency for Science, Technology and ResearchInventors: Pascal Beguin, Walter Hunziker
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Publication number: 20150031748Abstract: There is provided a method of identifying candidate agents capable of modulating interaction between a first polypeptide and a second polypeptide, wherein the first polypeptide is ZO-2/TJP2 or a functional variant thereof and the second polypeptide is a Snail zinc finger transcription factor family member or a functional variant thereof.Type: ApplicationFiled: February 28, 2013Publication date: January 29, 2015Applicant: Agency for Science, Technology and ResearchInventors: Walter Hunziker, Choon Peng Goh
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Patent number: 8741292Abstract: The present invention relates to a novel gene encoding a protein termed Coiled Coil Domain Containing 95 (CCDC95) or a peptide fragments thereof. The present invention also relates to the use of CCDC95 in Modulation of RGK small binding protein via altering concentration or sub-cellular localization of RGK small binding protein with CCDC95 or a peptide fragments thereof.Type: GrantFiled: January 14, 2009Date of Patent: June 3, 2014Assignee: Agency for Science, Technology and ResearchInventors: Pascal Beguin, Walter Hunziker
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Publication number: 20110091464Abstract: The present invention relates to a novel gene encoding a protein termed Coiled Coil Domain Containing 95 (CCDC95) or a peptide fragments thereof. The present invention also relates to the use of CCDC95 in Modulation of RGK small binding protein via altering concentration or sub-cellular localisation of RGK small binding protein with CCDC95 or a peptide fragments thereof.Type: ApplicationFiled: January 14, 2009Publication date: April 21, 2011Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Pascal Beguin, Walter Hunziker
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Publication number: 20100272737Abstract: The present invention relates to a novel gene encoding a protein termed voltage gated calcium channels ? subunit anchoring regulator protein (VDCC BARP) or a peptide fragments thereof. The present invention also relates to the use of VDCC BARP in Modulation of voltage gated calcium channels via altering the concentration of VDCC BARP or a peptide fragments thereof.Type: ApplicationFiled: June 18, 2008Publication date: October 28, 2010Applicant: Agency For Science ,Technology and ResearchInventors: Pascal Beguin, Walter Hunziker
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Patent number: 7700824Abstract: A non-human animal which has a reduced amount of functional TAZ polypeptide and/or TAZ-like polypeptide, or a reduced amount of nucleic acid encoding said polypeptide. A method for generating a non-human animal which develops PKD comprising reducing the amount of functional TAZ polypeptide and/or TAZ-like polypeptide, or nucleic acid encoding said polypeptide. A method of screening for compounds of use in preventing or treating PKD wherein a non-human animal is administered with a test compound and the effect of the test compound on the amount or function of TAZ polypeptide and/or a TAZ-like polypeptide and/or a polypeptide regulated by TAZ or a TAZ-like polypeptide function, or the amount of nucleic acid encoding said polypeptide, is assessed.Type: GrantFiled: August 3, 2005Date of Patent: April 20, 2010Assignee: Agency for Science, Technology and ResearchInventors: M. Zakir Hossain, Walter Hunziker
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Publication number: 20060056948Abstract: A non-human animal which has a reduced amount of functional TAZ polypeptide and/or TAZ-like polypeptide, or a reduced amount of nucleic acid encoding said polypeptide. A method for generating a non-human animal which develops PKD comprising reducing the amount of functional TAZ polypeptide and/or TAZ-like polypeptide, or nucleic acid encoding said polypeptide.Type: ApplicationFiled: August 3, 2005Publication date: March 16, 2006Applicant: Agency for Science, Technology and ResearchInventors: M. Hossain, Walter Hunziker
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Patent number: 4432103Abstract: A modular steam bath cabinet has a steam generating system including a heated, inclined evaporating surface over which heated liquid flows to cause evaporation of the liquid. Any known evaporated liquid is collected, reheated and recirculated. Heated liquid may also be circulated to a shower nozzle. The steam generating system is part of the module, which includes the floor of the cabinet.Type: GrantFiled: August 25, 1981Date of Patent: February 21, 1984Inventor: Walter Hunziker
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Patent number: 4352086Abstract: A method and a circuit arrangement for modifying central control information commands forming signal programs in traffic signal systems in particular street traffic signal systems, the central control information commands being output from a central station to intersection devices of the system in order to control signal generators assigned to the intersection devices. This modification is to occur through the use of traffic information which are determined in the traffic areas whose traffic flows are to be controlled by the signal generators of the intersection devices. In order to be able to undertake a modification of the signal program sequencing in the respective intersection devices, modification time areas are determined in the form of partially overlapping central control information commands, in particular binary "1's" transmitted from the central station to the respective intersection device.Type: GrantFiled: May 1, 1980Date of Patent: September 28, 1982Assignee: Siemens AktiengesellschaftInventor: Walter Hunziker