Abstract: An emergency call is initiated on behalf of a remote user by another software user who determines that the remote software user is experiencing an emergency event. During a real-time communication, a remote emergency alert is received from a first client device associated with a first user. The remote emergency alert identifies a second user associated with a second client device while the first client device and the second client device are in communication via real-time communication software. Based on location information determined for the second client device responsive to the remote emergency alert, an emergency call is initiated with a public safety answering point local to the second client device for indicating an emergency event associated with the second user to the public safety answering point on behalf of the second user.

Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: Implantable electrodes with power delivery wearable for treating sleep apnea, and associated systems and methods are disclosed herein. A representative system includes non-implantable signal generator worn by the patient and having an antenna that directs a mid-field RF power signal to an implanted electrode. The implanted electrode in turn directs a lower frequency signal to a neural target, for example, the patient's hypoglossal nerve. Representative signal generators can have the form of a mouthpiece, a collar or other wearable, and/or a skin-mounted patch.

Abstract: A container having a base and a lid is provided. The lid may be rotatable about a hinge from a closed configuration to an open configuration and may be secured, via one or more latching assemblies. The latching assembly may comprise a latch body, a locking member, a biasing member, and an activating member. Additional features of the container may include handles and strength increasing features. The base and lid may also feature attachment points for various accessories. A carry strap may attach to the base of the container to allow a user to lift and carry the container. The container may also have a wheels attached to the bottom portion and/or across the bottom portion to one side of the sidewall structure. In addition, in exemplary containers with wheels, a pull handle may be attached to a side opposite the wheels. The lid may include a lid support member that can act as a molle board to releasably secure items to the lid support member while also providing structural support to the lid.

Abstract: A composition of materials including a first compound having a structure according to Formula I

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: An emergency call is initiated on behalf of a remote user by another software user who determines that the remote software user is experiencing an emergency event. During a real-time communication, a remote emergency alert is received from a first client device associated with a first user. The remote emergency alert identifies a second user associated with a second client device while the first client device and the second client device are in communication via real-time communication software. Based on location information determined for the second client device responsive to the remote emergency alert, an emergency call is initiated with a public safety answering point local to the second client device for indicating an emergency event associated with the second user to the public safety answering point on behalf of the second user.

Abstract: A system includes a control computer that is programmed to perform an authentication based on an encryption key, upon being connected to a vehicle communication network. The computer is programmed to control vehicle operation including at least one of propulsion, braking, and steering, upon authentication by a vehicle computer that is physically attached to the communication network.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: A system includes a network and a telephony server. The network is associated with an independent carrier (IC), a native carrier, or both. The network includes a telephone gateway, an internet gateway, a first device associated with the IC, and a second device associated with the native carrier. The first device communicates with the telephone gateway. The second device communicates with the internet gateway. The telephony server is associated with the native carrier. The telephony server supports traffic from the first device and the second device. The telephony server includes a PBX and a session border controller (SBC). The SBC communicates with the telephone gateway via a session initiation protocol (SIP) trunk.

Abstract: Methods and systems are described for controlling output of a fuel cell that generates electrical power for an electric machine that propels a vehicle. In one example, a driver demand power reduction is anticipated and output of the fuel cell is adjusted before the driver demand power is reduced so that a greater amount of electric charge may be stored in an electric energy storage device.

Abstract: Implantable electrodes with power delivery wearable for treating sleep apnea, and associated systems and methods are disclosed herein. A representative system includes non-implantable signal generator worn by the patient and having an antenna that directs a mid-field RF power signal to an implanted electrode. The implanted electrode in turn directs a lower frequency signal to a neural target, for example, the patient's hypoglossal nerve. Representative signal generators can have the form of a mouthpiece, a collar or other wearable, and/or a skin-mounted patch.

Abstract: A vehicle includes an electric machine and a controller. The controller is programmed to, in response to releasing an accelerator pedal during a first driving scenario that is based on a first set of navigation data, increase regenerative braking torque of the electric machine to a first value. The controller is further programmed to, in response to releasing the accelerator pedal during a second driving scenario that is based on a second set of navigation data, increase the regenerative braking torque of the electric machine to a second value that is less than the first value.

Abstract: An adjustable hangar for attaching an elongate beam to a structural building member includes a lower module and an upper module that are engaged with one another in a vertically reciprocal manner. The lower module includes a bottom web for supporting an edge of a beam. The upper module includes a top panel opposite and spaced apart from the support web. When a beam is installed between top panel and bottom web, the upper module and lower module may be contracted to adjust the relative position of the top panel and bottom web. In an embodiment, the position can be contracted to trap the top edge and bottom edge of the beam between the top panel and bottom web.

Abstract: An adjustable hangar for attaching an elongate beam to a structural building member includes a lower module and an upper module that are engaged with one another in a vertically reciprocal manner. The lower module includes a pair of parallel side panels spaced apart from one another and a lower beam support web. The upper module includes a top panel opposite the support web and a pair of opposite side members. The upper module further includes an upper support flange substantially parallel to the support web. In one embodiment, the upper module side members engage with the lower module in a vertically slidable relationship and define a beam receipt channel therebetween. When a beam is installed in the receipt channel, the upper and lower modules are adjusted vertically to trap the beam between the upper panel and support web with the beam circumscribed by the hanger.

Abstract: Implantable electrodes with power delivery wearable for treating sleep apnea, and associated systems and methods are disclosed herein. A representative system includes non-implantable signal generator worn by the patient and having an antenna that directs a mid-field RF power signal to an implanted electrode. The implanted electrode in turn directs a lower frequency signal to a neural target, for example, the patient's hypoglossal nerve. Representative signal generators can have the form of a mouthpiece, a collar or other wearable, and/or a skin-mounted patch.

Abstract: A vehicle includes a fuel cell system (FCS), a traction battery, and a controller. The controller controls the FCS to output a constant amount of power throughout a vehicle trip. Responsive to a demanded power greater than the constant amount, the controller controls the traction battery to output an amount of power commensurate with a difference between the demanded power and the constant amount.

Abstract: A fuel cell and battery power management system for a fuel cell-powered vehicle includes an electric traction motor, a traction battery in electrical communication with the electric traction motor, a fuel cell stack in electrical communication with the traction battery and the electric traction motor, and a vehicle control system. The vehicle control system is configured to operate the vehicle with at a first discharge power level and a first charging power level if fuel cell power is sufficient alone to navigate the uphill grade and to build up battery state of charge by charging the traction battery at a second charging power level when the vehicle is approaching an uphill grade if fuel cell power is not sufficient alone to navigate the uphill grade. The vehicle control system is further configured to initiate proactive depletion of the battery SOC to enable powertrain braking and to provide regenerative power.

Abstract: A system and method for detecting an anomaly of an optically transparent or translucent object are disclosed. The system and method include a light source configured to emit light, a light transmission element having a textured surface, and an optical couplant configured to be disposed between the light transmission element and the object. At least a portion of the light emitted by the light source is configured to pass into the light transmission element through the textured surface and pass into the object through the optical couplant. At least a portion of the light that passes into the object internally reflects within the object and impinges on the anomaly to provide an illumination that indicates the location of the anomaly.

Abstract: Intraoral appliances are disclosed that provide electrical stimulation to tissue in a patient's oral cavity in a manner that reduces apnea events during sleep. A representative appliance can induce a current or currents through tissue and/or anatomical structures in a manner that maintains upper airway tone and/or patency.