Patents by Inventor Walter Keung

Walter Keung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF
    Publication number: 20230212152
    Abstract: The disclosure provides compounds of formula II with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
    Type: Application
    Filed: June 9, 2021
    Publication date: July 6, 2023
    Inventors: Lee D. Arnold, Andy Jennings, Walter Keung
  • INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF
    Publication number: 20230192663
    Abstract: The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
    Type: Application
    Filed: February 14, 2023
    Publication date: June 22, 2023
    Inventors: Lee D. Arnold, Andy Jennings, Walter Keung
  • INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF
    Publication number: 20220402896
    Abstract: The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
    Type: Application
    Filed: July 7, 2022
    Publication date: December 22, 2022
    Inventors: Lee D. Arnold, Andy Jennings, Walter Keung
  • Inhibitors of cysteine proteases and methods of use thereof
    Patent number: 11524940
    Abstract: The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: December 13, 2022
    Assignee: Pardes Biosciences, Inc.
    Inventors: Lee D. Arnold, Andy Jennings, Walter Keung
  • INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF
    Publication number: 20220380347
    Abstract: The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
    Type: Application
    Filed: May 3, 2021
    Publication date: December 1, 2022
    Inventors: Lee D. Arnold, Uri Lopatin, Walter Keung
  • Inhibitors of cysteine proteases and methods of use thereof
    Patent number: 11472793
    Abstract: The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
    Type: Grant
    Filed: February 4, 2022
    Date of Patent: October 18, 2022
    Assignee: Pardes Biosciences, Inc.
    Inventors: Lee D. Arnold, Andy Jennings, Walter Keung
  • INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF
    Publication number: 20220324844
    Abstract: The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
    Type: Application
    Filed: June 15, 2022
    Publication date: October 13, 2022
    Inventors: Lee D. Arnold, Andy Jennings, Walter Keung
  • INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF
    Publication number: 20220162194
    Abstract: The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
    Type: Application
    Filed: February 4, 2022
    Publication date: May 26, 2022
    Inventors: Lee D. Arnold, Andy Jennings, Walter Keung
  • Inhibitors of cysteine proteases and methods of use thereof
    Patent number: 11312704
    Abstract: The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
    Type: Grant
    Filed: July 23, 2021
    Date of Patent: April 26, 2022
    Assignee: Pardes Biosciences, Inc.
    Inventors: Lee D. Arnold, Andy Jennings, Walter Keung
  • INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF
    Publication number: 20210355111
    Abstract: The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
    Type: Application
    Filed: July 23, 2021
    Publication date: November 18, 2021
    Inventors: Lee D. Arnold, Andy Jennings, Walter Keung
  • Inhibitors of cysteine proteases and methods of use thereof
    Patent number: 11174231
    Abstract: The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: November 16, 2021
    Assignee: Pardes Biosciences, Inc.
    Inventors: Lee D. Arnold, Andy Jennings, Walter Keung
  • Inhibitors of cysteine proteases and methods of use thereof
    Patent number: 11124497
    Abstract: The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
    Type: Grant
    Filed: April 14, 2021
    Date of Patent: September 21, 2021
    Assignee: Pardes Biosciences, Inc.
    Inventors: Lee D. Arnold, Andy Jennings, Walter Keung
  • Heteroarylamide inhibitors of TBK1
    Patent number: 9994547
    Abstract: Disclosed are compounds of formula 1: which are useful as inhibitors of TBK1. Also disclosed are pharmaceutical compositions which contain the compounds, methods for treatment of conditions associated with TBK1, and processes for making the compounds and intermediates thereof.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: June 12, 2018
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Simone Bigi, Walter Keung, Steve Swann, Phong H. Vu, Steven John Woodhead, Anthony R. Gangloff
  • HETEROARYLAMIDE INHIBITORS OF TBK1
    Publication number: 20170313675
    Abstract: Disclosed are compounds of formula 1: which are useful as inhibitors of TBK1. Also disclosed are pharmaceutical compositions which contain the compounds, methods for treatment of conditions associated with TBK1, and processes for making the compounds and intermediates thereof.
    Type: Application
    Filed: October 2, 2015
    Publication date: November 2, 2017
    Inventors: Simone Bigi, Walter Keung, Steve Swann, Phong H. Vu, Steven John Woodhead, Anthony R. Gangloff
  • Heteroarylamide inhibitors of TBK1
    Patent number: 9598424
    Abstract: The present invention provides compounds of formula 1: which are useful as inhibitors of TBK-1, pharmaceutical compositionst thereof, methods for treatment of conditions associated with TBK1, processes for making the compounds and intermediates thereof.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: March 21, 2017
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Walter Keung, Lily Kwok, Mark Sabat, Nicholas Scorah, Haixia Wang, Steven John Woodhead, Anthony R Gangloff
  • HETEROARYLAMIDE INHIBITORS OF TBK1
    Publication number: 20170015669
    Abstract: The present invention provides compounds of formula 1: which are useful as inhibitors of TBK-1, pharmaceutical compositions thereof, methods for treatment of conditions associated with TBK1, processes for making the compounds and intermediates thereof.
    Type: Application
    Filed: February 12, 2015
    Publication date: January 19, 2017
    Inventors: Walter Keung, Lily Kwok, Mark Sabat, Nicholas Scorah, Haixia Wang, Steven John Woodhead, Anthony R Gangloff
  • Renin inhibitors
    Patent number: 8138168
    Abstract: The invention relates to compounds having the formulae: wherein the variables are as defined herein. The invention further relates to methods of making and using these compounds, and pharmaceutical compositions, kits and articles of manufacture comprise the compounds.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: March 20, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Benjamin Jones, Stephen W. Kaldor, Walter Keung, Andre A. Kiryanov, Zhe Li, Jeffrey A. Stafford, John Tyhonas, Craig Behnke
  • Renin inhibitors
    Patent number: 8129538
    Abstract: The invention relates to compounds having the formula: wherein the variables are as defined herein. The invention further relates to methods of making and using these compounds, and pharmaceutical compositions, kits and articles of manufacture comprise the compounds.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: March 6, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Walter Keung, Zhe Li
  • Use of specific T2R taste receptors to identify compounds that block bitter taste
    Patent number: 8071320
    Abstract: Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste.
    Type: Grant
    Filed: August 11, 2010
    Date of Patent: December 6, 2011
    Assignee: Senomyx, Inc.
    Inventors: Alexey Pronin, Judy Connor, Huixian Tang, Walter Keung, Guy Servant, Jon Elliot Adler, Shawn O'Connell, Paul Brust
  • USE OF SPECIFIC T2R TASTE RECEPTORS TO IDENTIFY COMPOUNDS THAT BLOCK BITTER TASTE
    Publication number: 20100317035
    Abstract: Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste.
    Type: Application
    Filed: August 11, 2010
    Publication date: December 16, 2010
    Inventors: Alexey Pronin, Judy Connor, Huixian Tang, Walter Keung, Guy Servant, Jon Elliot Adler, Shawn O'Connell, Paul Brust