Abstract: The present invention composition relates to compositions and combination therapies for use in the prevention, management, amelioration or treatment of a cancer or RASopathy disorders in which targeted therapy is used, the composition comprising two enzyme inhibitors targeting two different conformations of an enzyme, or enzymes in the same functional family, implicated in the cancer or RASopathy disorders. The present invention also relates to methods for identifying enzyme inhibitors which may be suitable for use in treatments.

Abstract: The present invention relates to the prediction of metastasis by determining RKIP expression levels, and to products and kits adapted for such methods. In some embodiments, the present invention relates to methods of assigning a treatment or monitoring regime to a cancer patient according to the level of RKIP expression.

Abstract: The invention relates to the discovery of a novel amino acid sequence motif, herein termed the RKIP motif, and to the family of proteins defined by the presence of that motif. Proteins comprising the RKIP motif modulate kinases involved in signal transduction pathways. The RKIP motif forms the basis for screening assays for the identification of agents useful for modulating signal transduction pathways subject to RKIP family mediated regulation, and for the diagnosis and treatment of disorders involving inappropriate activities of pathways subject to RKIP family medicated regulation.

Abstract: The invention relates to the transcriptional regulation of a family of proteins defined by the presence of an RKIP motif. Proteins comprising the RKIP motif modulate kinases involved in signal transduction pathways. Transcriptional regulation of proteins containing an RKIP motif forms the basis for screening assays for the identification of agents useful for modulating signal transduction pathways subject to RKIP family mediated regulation, and for the diagnosis and treatment of disorders involving inappropriate activities of pathways subject to RKIP family mediated regulation.

Abstract: The invention relates to the discovery of a novel amino acid sequence motif, herein termed the RKIP motif, and to the family of proteins defined by the presence of that motif. Proteins comprising the RKIP motif modulate kinases involved in signal transduction pathways. The RKIP motif forms the basis for screening assays for the identification of agents useful for modulating signal transduction pathways subject to RKIP family mediated regulation, and for the diagnosis and treatment of disorders involving inappropriate activities of pathways subject to RKIP family mediated regulation.

Abstract: The instant invention is a compound of formulaA--X--Y--E.sub.n --R.sup.5in which A is a bis-indolylmaleinimide or indolopyrrolocarbazole useful in the treatment and/or prevention of cancer, viral diseases, thrombosis, heart rhythm disturbances, atherosclerosis, bronchopulmonary diseases, degenerative diseases of the central nervous system, inflammatory diseases, diseases of the immune system, psoriasis, and immune suppression. A pharmaceutical composition and methods of preparing the compounds are also included.