Abstract: A photochemical method is described for treating cancer wherein phycocyanin is administered to a patient suffering from internal or skin cancer. Once administered, phycocyanin is selectively taken up into cancer cells, and upon subsequent irradiation destruction of the cancer cells occurs. Phycocyanin offers several advantages over prior art chemicals used for similar purposes. First, it is only marginally sensitive to the ultraviolet portion of the spectrum; consequently patients can be irradiated without concern that they will be sensitized to subsequent exposure to sunlight. Second, phycocyanin is selectively taken up into cancer cells with little or no uptake by surrounding normal cells. This ensures that upon subsequent irradiation that the tumors are selectively destroyed with little or no damage to the surrounding cells or tissue. A variety of different types of cancer cells can be effectively treated by this method; treatments of breast cancer, leukemia and murine tumors are described.

Abstract: A photochemical method is described for treating atherosclerosis or cancer wherein phycocyanin is injected into a patient suffering from one of these diseases. Once injected, phycocyanin is selectively taken up into atherosclerotic plaques or cancer cells, and upon subsequent irradiation destruction of the atherosclerotic plaques or cancer cells occurs. Phycocyanin offers several advantages over prior art chemicals used for similar purposes. First it is only marginally sensitive to the ultraviolet portion of the spectrum; consequently patients can be irradiated without concern that they will be sensitized to subsequent exposure to sunlight. Second, phycocyanin is selectively taken up into atherosclerotic plaques, with little or no uptake by surrounding normal cells. This ensures that upon subsequent irradiation that the atherosclerotic plaques are selectively destroyed with little or no damage to the surrounding cells or tissue.

Abstract: An array of miniature ultrasound crystals mounted on preassembled subassembly which is, in turn, mounted on a small lumen catheter provides dimensional and other quantitative information relating to arterial wall geometry and character at disease or obstruction sites. Balloons also mounted to the catheter make it possible to use the catheter for the angioplasty (PCTA) procedure while actually imaging, in real time, the artery being dilatated and unblocked by the procedure. Efficient, highly miniature transducers are presented along with several different configurations for catheter structure containing fluid lumen, through-lumen, and electrical microcable assemblies for conducting electrical signals to and from the transducers.

Abstract: A system for combining at least one analog signal, such as EKG signal, and an image signal, such as video signal representing a fluoroscopic view of a patient's heart or the like. The system includes a summing amplifier, which provides an input to a TV monitor and/or video recorder. The first input to the summing amplifier is provided from a TV camera arranged to view a physiological activity. A second input to the summing amplifier is provided from an encoder which receives one analog signal representing physiological data. The encoder includes an analog-to-digital (A/D) converter which receives the analog signal and feeds it to a random access memory (RAM). The A/D converter and the RAM are controlled by sync signals derived from a master camera control unit, which also provides sync signals to the TV camera.

Abstract: An ultrasonic diagnostic technique utilized to determine the wall thickness of cardiac structures. In a preferred embodiment, the endocardial and epicardial surfaces of the left ventricular posterior wall are irradiated with an ultrasonic sound beam. The signal reflected at the epicardial-lung interface is much stronger than the signal from the surrounding myocardium and endocardial surface. In order to simultaneously visualize the endocardial and epicardial reflected signals, the echos received therefrom are processed through a switched gain receiver. That is, an oscillator rapidly switches the receiver gain between two levels that are independently set to display the two wall surfaces, the resultant echocardiogram displaying the high and low gain portions closely mixed whereby the wall thickness may be readily determined.