Patents by Inventor Walter Lima

Walter Lima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human RNase H1 oligonucleotide compositions thereof
    Publication number: 20070292875
    Abstract: The present invention provides oligonucleotides that can serve as substrates for human Type 2 RNase H. The present invention is also directed to methods of using these oligonucleotides in enhancing antisense oligonucleotide therapies.
    Type: Application
    Filed: March 21, 2007
    Publication date: December 20, 2007
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Stanley Crooke, Walter Lima, Hongjiang Wu, Muthiah Monoharan
  • Methods of using mammalian RNase H and compositions thereof
    Publication number: 20050164234
    Abstract: The present invention relates to methods for using mammalian RNase H, including human RNase H, and compositions thereof, particularly for reduction of a selected cellular RNA target via antisense technology. Methods and uses for increasing or decreasing RNase H levels and activity in cells and animals are disclosed.
    Type: Application
    Filed: September 16, 2004
    Publication date: July 28, 2005
    Inventors: Stanley Crooke, Walter Lima, Hongjiang Wu
  • Human RNase H and compositions and uses thereof
    Publication number: 20050153340
    Abstract: The present invention relates to methods for using mammalian RNase H, including human RNase H, and compositions thereof, particularly for reduction of a selected cellular RNA target via antisense technology. A novel human RNAse HII polypeptide and the polynucleotide sequence encoding it are also disclosed.
    Type: Application
    Filed: December 6, 2004
    Publication date: July 14, 2005
    Inventors: Stanley Crooke, Walter Lima, Hongjiang Wu
  • Methods of using mammalian RNase H and compositions thereof
    Publication number: 20050153921
    Abstract: The present invention relates to methods for using mammalian RNase H and compositions thereof, particularly for reduction of a selected cellular RNA target via antisense technology.
    Type: Application
    Filed: December 1, 2004
    Publication date: July 14, 2005
    Inventors: Brett Monia, Phillip Cook, Stanley Crooke, Walter Lima, Hongjiang Wu
  • Methods of using mammalian RNase H and compositions thereof
    Publication number: 20040180433
    Abstract: The present invention relates to methods for using mammalian RNase H, including human RNase H, and compositions thereof, particularly for reduction of a selected cellular RNA target via antisense technology. A novel human RNAse HII polypeptide and the polynucleotide sequence encoding it are also disclosed.
    Type: Application
    Filed: February 12, 2001
    Publication date: September 16, 2004
    Inventors: Stanley T. Crooke, Walter Lima, Hongjiang Wu
  • Human RNase H and compositions and uses thereof
    Publication number: 20030144496
    Abstract: The present invention provides polynucleotides and polypeptides encoded thereby of human Type 2 RNase H. Methods of using these polynucleotides and polypeptides in enhancing antisense oligonucleotide therapies are also provided.
    Type: Application
    Filed: February 3, 2003
    Publication date: July 31, 2003
    Inventors: Stanley T. Crooke, Walter Lima, Hongjiang Wu
  • Human RNase H and compositions and uses thereof
    Publication number: 20020076712
    Abstract: The present invention provides polynucleotides and polypeptides encoded thereby of human Type 2 RNase H. Methods of using these polynucleotides and polypeptides in enhancing antisense oligonucleotide therapies are also provided.
    Type: Application
    Filed: May 18, 2001
    Publication date: June 20, 2002
    Inventors: Stanley T. Crooke, Walter Lima, Hongjiang Wu
  • Methods of using mammalian RNase H and compositions thereof
    Publication number: 20010044145
    Abstract: The present invention relates to methods for using mammalian RNase H and compositions thereof, particularly for reduction of a selected cellular RNA target via antisense technology.
    Type: Application
    Filed: March 5, 2001
    Publication date: November 22, 2001
    Inventors: Brett P. Monia, Phillip Dan Cook, Stanley T. Crooke, Walter Lima, Hongjiang Wu
  • Antisense oligonucleotides to the RAS gene
    Patent number: 5582972
    Abstract: Methods are provided for preparing antisense oligonucleotides which take advantage of RNA secondary and tertiary structure and for preparing antisense oligonucleotides which specifically hybridize to regions of RNA secondary and tertiary structure by comparing the affinity of the oligonucleotide for a structured RNA target to the affinity of the oligonucleotide for a length-matched oligonucleotide complement, and selecting an oligonucleotide having an affinity for the structured target which is not less than one thousandth of its affinity for the length-matched oligonucleotide complement. Oligonucleotides are also disclosed which are specifically hybridizable with regions of H-ras RNA having secondary and tertiary structure.
    Type: Grant
    Filed: December 14, 1992
    Date of Patent: December 10, 1996
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Walter Lima, Brett Monia, Susan Freier, David Ecker