Patents by Inventor Walter Losel

Walter Losel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6465483
    Abstract: A compound of formula I wherein A denotes a benzo, indolo or thieno group; R1 denotes thienyl or the group  wherein R7, R8 and R9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of the substituents can simultaneously represent phenyl or benzyl; R2, m, R3 and R4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: October 15, 2002
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter Lösel, Otto Roos, Dietrich Arndts
  • Patent number: 6180645
    Abstract: A compound of formula I wherein A denotes a benzo, indolo or thieno group; R1 denotes thienyl or the group wherein R7, R8 and R9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of the substituents can simultaneously represent phenyl or benzyl; R2, m, R3 and R4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: January 30, 2001
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter Lösel, Otto Roos, Dietrich Arndts
  • Patent number: 6136819
    Abstract: Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --O--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1 -.sub.6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4 -.sub.7)cycloalkyl, (C.sub.4 -.sub.6)cycloalkyl(C.sub.1 -.sub.5)alkyl or ##STR2## wherein R is (C.sub.1 -.sub.4)alkyl, hydroxy, --N.sub.3, halogen (F, Cl, Br, I), CF.sub.3 or (C.sub.1 -.sub.4)alkoxy,u is 0, 1, 2 or 3, andm, R.sup.2, R.sup.4, R.sup.7, R.sup.8 and R.sup.9 are as defined in the specification, as well as pharmaceutical preparations containing these compounds and the pharmaceutical use thereof.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: October 24, 2000
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Otto Roos, Walter Losel, Dietrich Arndts
  • Patent number: 6034094
    Abstract: The invention relates to the use of carbocyclically and heterocycally fused dihydroyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhabiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: March 7, 2000
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts, Franz Josef Kuhn, Ilse Strelle
  • Patent number: 5968948
    Abstract: Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --O--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1-6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4-7)cycloalkyl, (C.sub.4-6)cycloalkyl(C.sub.1-5)alkyl or ##STR2## wherein R is (C.sub.1-4)alkyl, hydroxy, --N.sub.3, halogen (F, Cl, Br, I), CF.sub.3 or (C.sub.1-4)alkoxy,u is 0, 1, 2 or 3, andm, R.sup.2, R.sup.4, R.sup.7, R.sup.8 and R.sup.9 are as defined in the specification, as well as pharmaceutical preparations containing these compounds and the pharmaceutical use thereof.
    Type: Grant
    Filed: May 16, 1997
    Date of Patent: October 19, 1999
    Assignee: Boerhinger Ingelheim GmbH
    Inventors: Otto Roos, Walter Losel, Dietrich Arndts
  • Patent number: 5925650
    Abstract: A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, whilst not more than 2 of the substituents can simultaneously represent phenyl or benzyl;R.sup.2, m, R.sup.3 and R.sup.4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: July 20, 1999
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts
  • Patent number: 5861412
    Abstract: Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: June 10, 1997
    Date of Patent: January 19, 1999
    Assignee: Boehringer Ingelheim KG
    Inventors: Dietrich Arndts, Walter Losel, Otto Roos
  • Patent number: 5837712
    Abstract: A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of the substituents can simultaneously represent phenyl or benzyl;R.sup.2, m, R.sup.3 and R.sup.4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 17, 1998
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts
  • Patent number: 5783576
    Abstract: New compounds of general formula (I) are provided: ##STR1## which are explained in the specification can be prepared by a variety of methods. The compounds may be used in pharmaceutical compositions.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: July 21, 1998
    Assignee: Boehringer Ingelheim KG
    Inventors: Otto Roos, Georg Speck, Walter Losel, Dietrich Arndts, Wolf-Dietrich Bechtel
  • Patent number: 5688793
    Abstract: The invention relates to new pyridazino?4',5':3,4!-pyrrolo?2,1-a!isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with acids and complex-forming agents, wherein X is O, S or NHO and R.sub.1, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are defined as in the specification, and pharmaceutical preparations containing these compounds.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: November 18, 1997
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts
  • Patent number: 5686462
    Abstract: The invention relates to the use of carbocyclically and heterocyclically fused dihydropyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhibiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: November 11, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts, Franz Josef Kuhn, Ilse Strelle
  • Patent number: 5677304
    Abstract: The invention relates to the use of 9-amino-pyridazino-?4',5':3,4!pyrrolo?2,1-a!isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with acids, bases and complexing agents for preparing agents for treating chronic inflammatory processes, ulcerative colitis and Crohn's disease, and for producing agents having an antiproliferative activity. The definitions of substituents R.sub.1 to R.sub.9 are given in the specification. The invention also relates to new compounds of general formula I which are also defined in the specification and their use as cerebroprotective agents.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: October 14, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Dietrich Arndts, Walter Losel, Otto Roos
  • Patent number: 5674878
    Abstract: Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 7, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Dietrich Arndts, Walter Losel, Otto Roos
  • Patent number: 5665729
    Abstract: The invention relates to the use of carbocyclically and heterocyclically fused dihydropyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhibiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: September 9, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Walter Losel, Otto Roos, Dietrich Arndts, Franz Josef Kuhn, Ilse Strelle
  • Patent number: 5661157
    Abstract: Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --0--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1-6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4-7)cycloalkyl, (C.sub.4-6)cycloalkyl(C.sub.1-5)alkyl or ##STR2## wherein R is (C.sub.1-4)alkyl, hydroxy, --N.sub.3, halogen (F, Cl, Br, I), CF.sub.3 or (C.sub.1-4)alkoxy,u is 0, 1, 2 or 3, andm, R.sup.2, R.sup.4, R.sup.7, R.sup.8 and R.sup.9 are as defined in the specification, as well as pharmaceutical preparations containing these compounds and the pharmaceutical use thereof.
    Type: Grant
    Filed: December 21, 1994
    Date of Patent: August 26, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Otto Roos, Walter Losel, Dietrich Arndts
  • Patent number: 5643919
    Abstract: Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 1, 1997
    Assignee: Boehringer Ingelheim KG
    Inventors: Dietrich Arndts, Walter Losel, Otto Roos
  • Patent number: 5627491
    Abstract: A circuit arrangement which comprises at least one stage which is to be fed by a source voltage from a common voltage source, at least one of these stages comprising a control signal generating circuit which can apply a control signal, to be derived from the source voltage, to a control signal output bus conductor which is common to all stages. A control signal input bus conductor can be connected to the control signal output bus conductor via a central bridge when the source voltage has a value within a first value range and which can be isolated from the control signal output bus conductor by the central bridge when the source voltage has a value within a second value range. Each stage includes a respective control circuit which can be connected to the control signal input bus conductor in order to receive the control signal and which can adjust the stage to a source voltage from the associated value range by application or interruption of the control signal.
    Type: Grant
    Filed: July 20, 1995
    Date of Patent: May 6, 1997
    Assignee: U.S. Philips Corporation
    Inventor: Walter Losel
  • Patent number: 5136175
    Abstract: A circuit arrangement for the supply of emergency current in the case of a mains failure, comprises an electrolytic capacitor which is connected through a diode to a charging voltage which is higher than the required output voltage. The new current supply circuit arrangement avoids energy losses as far as possible and guarantees a sufficiently rapid availability of the energy to be stored in the electrolytic capacitor in that the capacitor charging voltage is derived from an auxialiary voltage source. In a further embodiment, a transistor is connected between the electrolytic capacitor and the output terminal of the current supply circuit and is operated in the inverse mode in order to precharge the electrolytic capacitor with a base charge. This current supply circuit arrangement can be used for the emergency current supply of microcomputer systems.
    Type: Grant
    Filed: December 8, 1988
    Date of Patent: August 4, 1992
    Assignee: U.S. Philips Corporation
    Inventor: Walter Losel
  • Patent number: 5087871
    Abstract: A power supply circuit which includes a current limit circuit for limiting the inrush current when the power supply is switched on. The current limit circuit is coupled between a supply voltage at the input end of the power supply and a storage capacitor at the output end of the power supply. The current limit circuit includes a first semiconductor switch having a resistor in parallel with its switching path. In parallel with the control path of the first semiconductor switch is a parallel circuit that includes a first capacitor, a first resistor and the switching path of a second semiconductor switch. The control electrode of the second semiconductor switch is connected to a tap on a first voltage divider to which a second capacitor is connected in parallel. The switching path of a third semiconductor switch is connected parallel to the control path of the second semiconductor switch.
    Type: Grant
    Filed: October 2, 1990
    Date of Patent: February 11, 1992
    Assignee: U.S. Philips Corporation
    Inventor: Walter Losel
  • Patent number: 5008273
    Abstract: Amino acid derivatives of general formula ##STR1## (the definitions of the various symbols being explained in the specification) are suitable for treating high blood pressure and for cardioprotection. The new compounds are prepared and used in the usual way.
    Type: Grant
    Filed: September 6, 1989
    Date of Patent: April 16, 1991
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Gerd Schnorrenberg, Otto Roos, Walter Losel, Ingrid Wiedemann, Wolfram Gaida, Wolfgang Hoefke, Dietrich Arndts, Ilse Streller