Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), are provided.

Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), are provided.

Abstract: A method for managing data processes in a network of computing resources includes: receiving at least one child request being routed from an intermediary device to at least one corresponding destination device, the at least one child request requesting execution of at least one corresponding child data process, each of the at least one child data process for executing at least a portion of the at least one parent data process from an instructor device, and each of the at least one child request including a destination key derived at least in part from the at least one instructor key; storing the at least one child request in at least one storage device; modifying the at least one child request upon receiving a child request modification signal; and generating signals for communicating the child requests to one or more requesting devices.

Abstract: In one aspect, a system for managing data processes in a network of computing resources is configured to: receive, from an instructor device, a parent request for execution of at least one parent data process executable by a plurality of computing resources at least one computing resource; generate at least one child request for execution of at least one corresponding child data process for routing to at least one corresponding destination device, each of the at least one child data process for executing at least a portion of the at least one parent data process, and each of the at least one child request including a respective destination key derived from at least one instructor key; and route each of the at least one child request to the at least one corresponding destination device. The at least one child request can be obtained by a supervisor server via the routing.

Abstract: A computer system and computer-implemented method for duplicating an application state are provided, the method including: recording one or more point-in-time characteristics generated by prior user inputs at one or more user interface elements, the one or more point-in-time characteristics associated with a first application state of a first application instance; transferring the one or more point-in-time characteristics to the provisioned memory resources for generating the second application state; generating a second application instance based on the one or more point-in-time characteristics; configuring the second application state based on the one or more point-in-time characteristics to duplicate the first application state of the first application instance; and storing the prior user inputs in a journal, wherein the journal is configured to enable reproduction of a state of a plurality of modified states of the first application instance.

Abstract: Systems, methods, and computer-readable media for coordinating processing of data by multiple networked computing resources include monitoring data associated with a plurality of networked computing resources, and coordinating the routing of data processing segments to the networked computing resources.

Abstract: In one aspect, a system for managing data processes in a network of computing resources is configured to: receive, from an instructor device, a parent request for execution of at least one parent data process executable by a plurality of computing resources at least one computing resource; generate at least one child request for execution of at least one corresponding child data process for routing to at least one corresponding destination device, each of the at least one child data process for executing at least a portion of the at least one parent data process, and each of the at least one child request including a respective destination key derived from at least one instructor key; and route each of the at least one child request to the at least one corresponding destination device. The at least one child request can be obtained by a supervisor server via the routing.

Abstract: Systems, methods, and computer-readable media for coordinating processing of data by multiple networked computing resources include monitoring data associated with a plurality of networked computing resources, and coordinating the routing of data processing segments to the networked computing resources.

Abstract: Systems, methods, and devices for communication are described. A communication system includes a first communication device configured to communicate with a backup device and a destination; and a first tapping device for monitoring messages sent over a first communication link between the first communication device and the backup device. The first communication device includes at least one processor configured to: before sending a first message destined for the destination, send a backup message corresponding to the first message over the communication link for backup at the backup device; and upon confirmation of a tap copy of the backup message from the first tapping device, send the first message to the destination.

Abstract: Systems, methods, and devices for communication are described. A communication system includes a first communication device configured to communicate with a backup device and a destination; and a first tapping device for monitoring messages sent over a first communication link between the first communication device and the backup device. The first communication device includes at least one processor configured to: before sending a first message destined for the destination, send a backup message corresponding to the first message over the communication link for backup at the backup device; and upon confirmation of a tap copy of the backup message from the first tapping device, send the first message to the destination.

Abstract: Methods, systems, and non-transitory computer readable storage media are disclosed for provide a continuous-variable input element for customizing pressure sensitivity for a touch-based input. For instance, the disclosed system utilizes an input element value corresponding to a position of the continuous-variable input element to determine a plurality of variables of a pressure sensitivity curve. The disclosed system determines an exponent of an exponential curve function and an ending value for the exponential curve function based on the input element value. Additionally, the disclosed systems generates the pressure sensitivity curve utilizing the exponential curve function. The disclosed system uses the pressure sensitivity curve to determine a display output of a graphical user interface tool in response to a pressure of an input.

Abstract: A method for managing data processes in a network of computing resources includes: receiving at least one child request being routed from an intermediary device to at least one corresponding destination device, the at least one child request requesting execution of at least one corresponding child data process, each of the at least one child data process for executing at least a portion of the at least one parent data process from an instructor device, and each of the at least one child request including a destination key derived at least in part from the at least one instructor key; storing the at least one child request in at least one storage device; modifying the at least one child request upon receiving a child request modification signal; and generating signals for communicating the child requests to one or more requesting devices.

Abstract: A battery monitoring system continuously calculates the estimated runtime of a bank of batteries in a battery backup system during both a period of operation when the load current is supplied by a commercial source of AC power and during a period of operation when the commercial source of AC power is not present and the load current is supplied by the bank. The estimated runtime may be displayed to an operator and used to alert the operator if the cutoff voltage of a battery in the bank is at or near its cutoff voltage. The system may open a circuit breaker to avoid catastrophic damage before the cutoff voltage is reached.

Abstract: A computer system and computer-implemented method for duplicating an application state are provided, the method including: recording one or more point-in-time characteristics generated by prior user inputs at one or more user interface elements, the one or more point-in-time characteristics associated with a first application state of a first application instance; transferring the one or more point-in-time characteristics to the provisioned memory resources for generating the second application state; generating a second application instance based on the one or more point-in-time characteristics; configuring the second application state based on the one or more point-in-time characteristics to duplicate the first application state of the first application instance; and storing the prior user inputs in a journal, wherein the journal is configured to enable reproduction of a state of a plurality of modified states of the first application instance.

Abstract: The present invention relates to a magnetic piston system that includes: an electromagnetic cap; a magnetized piston; a cylinder which receives the piston and enables free movement of a piston through the cylinder; a series of time pulse rings surrounding the perimeter of the cylinder that enable movement of the piston through the cylinder during use; and a piston rod extending from a cylinder attached at the distal end to a crankshaft.

Abstract: A method for managing data processes in a network of computing resources includes: receiving at least one child request being routed from an intermediary device to at least one corresponding destination device, the at least one child request requesting execution of at least one corresponding child data process, each of the at least one child data process for executing at least a portion of the at least one parent data process from an instructor device, and each of the at least one child request including a destination key derived at least in part from the at least one instructor key; storing the at least one child request in at least one storage device; modifying the at least one child request upon receiving a child request modification signal; and generating signals for communicating the child requests to one or more requesting devices.

Abstract: In one aspect, a system for managing data processes in a network of computing resources is configured to: receive, from an instructor device, a parent request for execution of at least one parent data process executable by a plurality of computing resources at least one computing resource; generate at least one child request for execution of at least one corresponding child data process for routing to at least one corresponding destination device, each of the at least one child data process for executing at least a portion of the at least one parent data process, and each of the at least one child request including a respective destination key derived from at least one instructor key; and route each of the at least one child request to the at least one corresponding destination device. The at least one child request can be obtained by a supervisor server via the routing.

Abstract: There is provided a computer-implemented method for duplicating an application state, the method including: recording one or more point-in-time characteristics of an original application state of an application, the recording including: parsing underlying code for the application to identify (i) a set of state variables that together define the original application state and (ii) a set of logical breadcrumbs identifying a pre-determined number of past actions that led to the original application state; establishing one or more logical anchor points based on the set of state variables; provisioning memory resources to support a duplicate application state; on the provisioned memory resources, initiating a copy of the application; transferring the one or more point-in-time characteristics to the provisioned memory resources, the transferring including: configuring the copy of the application using the one or more point-in-time characteristics to regenerate the original application state on the copy of the appli

Abstract: In one aspect, a system for managing data processes in a network of computing resources is configured to: receive, from an instructor device, a parent request for execution of at least one parent data process executable by a plurality of computing resources at least one computing resource; generate at least one child request for execution of at least one corresponding child data process for routing to at least one corresponding destination device, each of the at least one child data process for executing at least a portion of the at least one parent data process, and each of the at least one child request including a respective destination key derived from at least one instructor key; and route each of the at least one child request to the at least one corresponding destination device. The at least one child request can be obtained by a supervisor server via the routing.

Abstract: Systems, methods, and computer-readable media for coordinating processing of data by multiple networked computing resources include monitoring data associated with a plurality of networked computing resources, and coordinating the routing of data processing segments to the networked computing resources.