Patents by Inventor Walter P. Cullen

Walter P. Cullen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polycyclic ether antibiotic having anthelmintic, anticoccidial and growth promotant activity
    Patent number: 5965445
    Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces sp. ATCC 55028. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, as a growth promotant in cattle and swine, and as an anthelmintic in mammals, particularly in dogs, cats, sheep, cattle and swine.
    Type: Grant
    Filed: March 11, 1992
    Date of Patent: October 12, 1999
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, John P. Dirlam, Hiroshi Maeda, Junsuke Tone
  • Acidic polycyclic ether useful as an anticoccidial agent and as a growth promotant
    Patent number: 5891727
    Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53676. This novel antibiotic is useful as an anticoccidial in chickens and as a growth promotant in cattle and swine.
    Type: Grant
    Filed: March 11, 1992
    Date of Patent: April 6, 1999
    Assignee: Pfizer Inc.
    Inventors: John P. Dirlam, Walter P. Cullen, Hiroshi Maeda, Junsuke Tone
  • Acidic polycyclic ether antibiotic
    Patent number: 5494931
    Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 55080. This novel antibiotic is useful as an anticoccidial in poultry, in the prevention and treatment of swine dysentery and as a growth promotant in cattle and swine.
    Type: Grant
    Filed: December 6, 1994
    Date of Patent: February 27, 1996
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, John P. Dirlam, Hiroshi Maeda, Junsuke Tone
  • Streptomyces braegensis strain and its cultivation in a process for producing C.sub.9 -desoxo-FK-520
    Patent number: 5494820
    Abstract: A compound of the formula ##STR1## is a novel immunosuppressant agent prepared by fermenting Steptomyces braeaensis subsp. pulcherrimus, ATCC 55150, or another compound of the formula I producing strain and extracting the compound of the formula I from the fermentation medium. The compound is useful in treating transplant rejection and autoimmune diseases.
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: February 27, 1996
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, Mark A. Guadliana, Liang H. Huang, Keiji Kaneda, Nakao Kojima, Gloria Kostek, Satoshi Nishiyama, Yuji Yamauchi, Yasuhiro Kojima
  • Process for producing acidic polycyclic ether antibiotic having anticoccidial and growth promant activity with Actinomadura
    Patent number: 5478735
    Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53764. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
    Type: Grant
    Filed: September 6, 1994
    Date of Patent: December 26, 1995
    Assignee: Pfizer Inc.
    Inventors: John P. Dirlam, Walter P. Cullen, Hiroshi Maeda, Junsuke Tone
  • Acidic polycyclic ether antibiotic
    Patent number: 5418152
    Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 55080. This novel antibiotic is useful as an anticoccidial in poultry, in the prevention and treatment of swine dysentery and as a growth promotant in cattle and swine.
    Type: Grant
    Filed: March 12, 1993
    Date of Patent: May 23, 1995
    Assignee: Pfizer Inc
    Inventors: Walter P. Cullen, John P. Dirlam, Hiroshi Maeda, Junsuke Tone
  • Microorganism for producing polycyclic ether antibiotics
    Patent number: 5403738
    Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53764. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: April 4, 1995
    Assignee: Pfizer Inc.
    Inventors: John P. Dirlam, Walter P. Cullen, Hiroshi Maeda, Junsuke Tone
  • Acidic polycyclic ether antibiotic having an anticoccidial and growth promotant activity
    Patent number: 5298524
    Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53764. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
    Type: Grant
    Filed: March 27, 1992
    Date of Patent: March 29, 1994
    Assignee: Pfizer Inc.
    Inventors: John P. Dirlam, Walter P. Cullen, Hiroshi Maeda, Junsuke Tone
  • Acidic polycyclic ether useful as an anticoccidial agent and as a growth promotant
    Patent number: 5206263
    Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces hygroscopicus ATCC 53626. This novel antibiotic is useful as an anticoccidial in chickens and as a growth promotant in cattle and swine.
    Type: Grant
    Filed: December 5, 1989
    Date of Patent: April 27, 1993
    Assignee: Pfizer Inc.
    Inventors: John P. Dirlam, Walter P. Cullen, Hiroshi Maeda, Junsuke Tone
  • Acidic polycyclic ether antibiotic having anticoccidial and growth promotant activity
    Patent number: 5158937
    Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53708. This novel antibiiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
    Type: Grant
    Filed: June 15, 1990
    Date of Patent: October 27, 1992
    Assignee: Pfizer Inc.
    Inventors: John P. Dirlam, Walter P. Cullen, Hiroshi Maeda, Junsuke Tone
  • Polycyclic ether antibiotic having anthelmintic, anticoccidial and growth promotant activity
    Patent number: 5155097
    Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces sp. ATCC 55028. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, as a growth promotant in cattle and swine, and as an anthelmintic in mammals, particularly in dogs, cats, sheep, cattle and swine.
    Type: Grant
    Filed: May 23, 1990
    Date of Patent: October 13, 1992
    Assignee: Pfizer Inc
    Inventors: Walter P. Cullen, John P. Dirlam, Hiroshi Maeda, Junsuke Tone
  • Acidic polycyclic ether useful as an anticoccidial agent and as a growth promotant
    Patent number: 5147858
    Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53676. This novel antibiotic is useful as an anticoccidial in chickens and as a growth promotant in cattle and swine.
    Type: Grant
    Filed: April 16, 1990
    Date of Patent: September 15, 1992
    Assignee: Pfizer Inc
    Inventors: John P. Dirlam, Walter P. Cullen, Hiroshi Maeda, Junsuke Tone
  • Polycyclic ether antibiotic
    Patent number: 5100785
    Abstract: A new acidic polycyclic ether antibiotic UK-58,852 has the formula: ##STR1## wherein R and R.sup.1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in swine and ruminants. Two minor components, wherein R is H and R.sup.1 is CH.sub.3 and wherein R and R.sup.1 are both CH.sub.3, have also been isolated from the fermentation.
    Type: Grant
    Filed: December 17, 1990
    Date of Patent: March 31, 1992
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, Hiroshi Maeda, John C. Ruddock, Junsuke Tone
  • Acid polycyclic ether antibiotic
    Patent number: 5064855
    Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces sp. ATCC 53862. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
    Type: Grant
    Filed: January 28, 1991
    Date of Patent: November 12, 1991
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, James R. Hauske, Gloria J. Kostek, Hiroshi Maeda, Junsuke Tone
  • Polycyclic ether antibiotics
    Patent number: 4992423
    Abstract: A new acidic polycyclic ether antibiotic UK-58,852 has the formula: ##STR1## wherein R and R.sup.1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization is swine and ruminants. Two minor components, where R is H and R.sup.1 is CH.sub.3 and wherein R and R.sup.1 are both CH.sub.3, have also been isolated from the fermentation.
    Type: Grant
    Filed: February 8, 1988
    Date of Patent: February 12, 1991
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, Hiroshi Maeda, John C. Ruddock, Junsuke Tone
  • Process for preparing macrolide antibiotics by culturing streptomyces hirsutus ATCC 53513
    Patent number: 4956283
    Abstract: An antibiotic complex, containing three major components, has been isolated from fermentations of a new strain of the microorganism Streptomyces hirautus. The major components are new, neutral, macrolide antibiotic compounds, which are useful as antibacterial agents against certain gram-positive bacteria.
    Type: Grant
    Filed: March 10, 1989
    Date of Patent: September 11, 1990
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, James R. Hauske, Hiroshi Maeda, Junsuke Tone
  • Acidic polycyclic ether antibiotic
    Patent number: 4920050
    Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces sp. ATCC 53862. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
    Type: Grant
    Filed: February 27, 1989
    Date of Patent: April 24, 1990
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, James R. Hauske, Gloria J. Kostek, Hiroshi Maeda, Junsuke Tone
  • Streptomyces sp. N664-30 which produces an ionophore antibacterial agent
    Patent number: 4908316
    Abstract: An antibiotic has been isolated from fermentation of a new Streptomyces culture. The new ionophore is active as an antibacterial and anticoccidial agent.
    Type: Grant
    Filed: February 29, 1988
    Date of Patent: March 13, 1990
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, John R. Oscarson, Junsuke Tone, Hiroshi Maeda
  • Neutral macrolide antibiotics from Streptomyces
    Patent number: 4835141
    Abstract: An antibiotic complex, containing three major components, has been isolated from fermentations of a new strain of the microorganism Streptomyces hirsutus. The major components are new, neutral, macrolide antibiotic compounds, which are useful as antibacterial agents against certain gram-positive bacteria.
    Type: Grant
    Filed: December 5, 1986
    Date of Patent: May 30, 1989
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, James R. Hauske, Hiroshi Maeda, Junsuke Tone
  • Inophore antibacterial agent from streptomyces
    Patent number: 4751317
    Abstract: An antibiotic has been isolated from fermentation of a new Streptomyces culture. The new ionophore is active as an antibacterial and anticoccidial agent.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: June 14, 1988
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, John R. Oscarson, Junsuke Tone, Hiroshi Maeda