Patents by Inventor Walter Perkins

Walter Perkins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11857597
    Abstract: The present invention provides certain lipo-glycopeptide cleavable derivatives and methods for using the same for the treatment of bacterial infections, for example, pulmonary bacterial infections. The LGPC derivatives include a cleavable moiety that in certain embodiments, is designed to allow for cellular uptake and/or a more rapid clearance of the glycopeptide metabolite (i.e., the cleaved glycopeptide) from the site of administration (e.g., the lung) as compared to the uncleaved LGPC.
    Type: Grant
    Filed: June 10, 2021
    Date of Patent: January 2, 2024
    Assignee: Insmed Incorporated
    Inventors: Ryan Heckler, Donna Konicek, Adam Plaunt, Vladimir Malinin, Walter Perkins
  • Patent number: 11795135
    Abstract: Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: October 24, 2023
    Assignee: Insmed Incorporated
    Inventors: Vladimir Malinin, Walter Perkins, Franziska Leifer, Donna Konicek, Zhili Li, Adam Plaunt
  • Publication number: 20220024980
    Abstract: The present invention provides certain lipo-glycopeptide cleavable derivatives and methods for using the same for the treatment of bacterial infections, for example, pulmonary bacterial infections. The LGPC derivatives include a cleavable moiety that in certain embodiments, is designed to allow for cellular uptake and/or a more rapid clearance of the glycopeptide metabolite (i.e., the cleaved glycopeptide) from the site of administration (e.g., the lung) as compared to the uncleaved LGPC. The bacterial infection can comprise intracellular bacteria, planktonic bacteria, bacteria present in a biofilm, or a combination thereof.
    Type: Application
    Filed: November 20, 2019
    Publication date: January 27, 2022
    Inventors: Donna Konicek, Adam Plaunt, Vladimir Malinin, Walter Perkins, Ryan Heckler
  • Publication number: 20210388028
    Abstract: Provided herein are compounds, compositions and methods for the treatment of Gram positive bacterial infections. The infection in some embodiments, is a pulmonary infection. The method for treating the bacterial infection, comprises in one embodiment, administering to a patient in need thereof, a composition comprising an effective amount of a compound a glycopeptide derivative of Formula (I) or (II), or a pharmaceutically acceptable salt of Formula (I) or (II). The bacterial infection can comprise intracellular bacteria, planktonic bacteria and/or bacteria present in a biofilm.
    Type: Application
    Filed: November 20, 2019
    Publication date: December 16, 2021
    Inventors: Donna Konicek, Adam Plaunt, Vladimir Malinin, Walter Perkins, Ryan Heckler
  • Patent number: 11148997
    Abstract: Methods for making prodrugs of treprostinil and treprostinil derivatives are provided. Specifically, methods are provided herein for producing prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide). The linkage, in one embodiment, is via an amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. The compounds provided herein can be used to treat pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: October 19, 2021
    Assignee: INSMED INCORPORATED
    Inventors: Vladimir Malinin, Walter Perkins, Franziska Leifer, Donna M. Konicek, Zhili Li, Adam Plaunt
  • Patent number: 11071769
    Abstract: The present invention provides certain lipo-glycopeptide cleavable derivatives and methods for using the same for the treatment of bacterial infections, for example, pulmonary bacterial infections. The LGPC derivatives include a cleavable moiety that in certain embodiments, is designed to allow for cellular uptake and/or a more rapid clearance of the glycopeptide metabolite (i.e., the cleaved glycopeptide) from the site of administration (e.g., the lung) as compared to the uncleaved LGPC.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: July 27, 2021
    Assignee: Insmed Incorporated
    Inventors: Ryan Heckler, Donna Konicek, Adam Plaunt, Vladimir Malinin, Walter Perkins
  • Patent number: 10995055
    Abstract: Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: May 4, 2021
    Assignee: INSMED INCORPORATED
    Inventors: Vladimir Malinin, Walter Perkins, Franziska Leifer, Donna Konicek, Zhili Li, Adam Plaunt
  • Patent number: 10526274
    Abstract: Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: January 7, 2020
    Assignee: INSMED INCORPORATED
    Inventors: Vladimir Malinin, Walter Perkins, Franziska Leifer, Donna Konicek, Zhili Li, Adam Plaunt
  • Patent number: 10471149
    Abstract: In one aspect, the invention provides a stabilized lipid-based glycopeptide antibiotic composition and a process for producing the same. In another aspect, the invention provides methods for treating a bacterial pulmonary infection by administering to a subject in need thereof a therapeutically effective amount of the stabilized lipid-based glycopeptide antibiotic composition.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: November 12, 2019
    Assignee: INSMED INCORPORATED
    Inventors: Walter Perkins, Vladimir Malinin
  • Publication number: 20190337888
    Abstract: Methods for making prodrugs of trepreostinil and treprostinil derivatives are provided. Specifically, methods are provided herein for producing prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide). The linkage, in one embodiment, is via an amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. The compounds provided herein can be used to treat pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension.
    Type: Application
    Filed: May 21, 2019
    Publication date: November 7, 2019
    Inventors: Vladimir Malinin, Walter Perkins, Franziska Leifer, Donna M. Konicek, Zhili Li, Adam Plaunt
  • Publication number: 20190248731
    Abstract: Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C3-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.
    Type: Application
    Filed: May 31, 2018
    Publication date: August 15, 2019
    Inventors: Vladimir MALININ, Walter Perkins, Franziska Leifer, Donna Konicek, Zhili Li, Adam Plaunt
  • Patent number: 10343979
    Abstract: Methods for making prodrugs of trepreostinil and treprostinil derivatives are provided. Specifically, methods are provided herein for producing prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide). The linkage, in one embodiment, is via an amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. The compounds provided herein can be used to treat pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: July 9, 2019
    Assignee: Insmed Incorporated
    Inventors: Vladimir Malinin, Walter Perkins, Franziska Leifer, Donna M. Konicek, Zhili Li, Adam Plaunt
  • Publication number: 20190022232
    Abstract: In one aspect, the invention provides a stabilized lipid-based glycopeptide antibiotic composition and a process for producing the same. In another aspect, the invention provides methods for treating a bacterial pulmonary infection by administering to a subject in need thereof a therapeutically effective amount of the stabilized lipid-based glycopeptide antibiotic composition.
    Type: Application
    Filed: September 26, 2018
    Publication date: January 24, 2019
    Inventors: Walter Perkins, Vladimir Malinin
  • Publication number: 20180360864
    Abstract: Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.
    Type: Application
    Filed: June 15, 2018
    Publication date: December 20, 2018
    Inventors: Walter Perkins, Vladimir Malinin, Xingong Li, Brian Miller, Dominique Seidel, Philipp Holzmann, Harald Schulz, Michael Hahn
  • Patent number: 10124066
    Abstract: In one aspect, the invention provides a stabilized lipid-based glycopeptide antibiotic composition and a process for producing the same. In another aspect, the invention provides methods for treating a bacterial pulmonary infection by administering to a subject in need thereof a therapeutically effective amount of the stabilized lipid-based glycopeptide antibiotic composition.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: November 13, 2018
    Assignee: INSMED INCORPORATED
    Inventors: Walter Perkins, Vladimir Malinin
  • Patent number: 10010518
    Abstract: Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: July 3, 2018
    Assignee: INSMED INCORPORATED
    Inventors: Vladimir Malinin, Walter Perkins, Franziska Leifer, Donna Konicek, Zhili Li, Adam Plaunt
  • Publication number: 20170320813
    Abstract: Methods for making prodrugs of trepreostinil and treprostinil derivatives are provided. Specifically, methods are provided herein for producing prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide). The linkage, in one embodiment, is via an amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. The compounds provided herein can be used to treat pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension.
    Type: Application
    Filed: November 18, 2015
    Publication date: November 9, 2017
    Inventors: Vladimir Malinin, Walter Perkins, Franziska Leifer, Donna M. Konicek, Zhili Li, Adam Plaunt
  • Publication number: 20170196900
    Abstract: Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.
    Type: Application
    Filed: December 15, 2016
    Publication date: July 13, 2017
    Inventors: Walter Perkins, Vladimir Malinin, Xingong LI, Brian Miller, Dominique Seidel, Philipp Holzmann, Harald Schulz, Michael Hahn
  • Publication number: 20170165374
    Abstract: Provided herein are pharmaceutical compositions comprising an antibiotic encapsulated in liposomes. The lipid membrane component of the liposomes, or portion thereof comprises an unsaturated phospholipid. The antibiotic-to-lipid component weight ratio of the liposomes ranges from about 0.5-to-1 to about 3-to-1. The pharmaceutical compositions in some embodiments also include free antibiotic, in addition to encapsulated antibiotic. Methods for treating bacterial infections, e.g., pulmonary bacterial infections such as nontuberculous mycobacterial infections with the pharmaceutical compositions are also provided.
    Type: Application
    Filed: November 18, 2016
    Publication date: June 15, 2017
    Inventors: Walter Perkins, Vladimir Malinin, Franziska Leifer, Carlos Figueroa, Keith DiPetrillo
  • Publication number: 20170049739
    Abstract: Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.
    Type: Application
    Filed: October 24, 2014
    Publication date: February 23, 2017
    Inventors: Adam Plaunt, Walter Perkins, Franziska Leifer, Donna M. Konicek, Zhili Li, Vladimir Malinin