Abstract: The present invention concerns a method for treating cancer, including haematological and solid tumors. In an embodiment, the method comprises impairing arginase activity and/or expression in immune cells, in particular T cells of a patient suffering from cancer. Arginase expression may be impaired by mutation (including deletion or truncation) of the arginase encoding gene, by RNA interference or by administration of an arginase inhibitor. In a preferred embodiment, the T cells are modified in the frame of CAR (Chimeric Antigen Receptor) therapy. The invention also provides a method of treatment combining impaired arginase activity with antibody-mediated blockage of negative immune checkpoint regulators (PDLL-PD1 and B7-CTLA4 inhibitory pathways).

Abstract: The present invention relates to a process for producing a pelletized stabilizer mixture for halogen-containing plastics, comprising the following steps: (a) heating, at from 40 to 100° C. in an extruder or kneader, a mixture comprising (A) at least one lubricant, (B) at least one substance having stabilizer activity, and (C) auxiliaries and additives, ?where at least 1% by weight of all of the substances, based on the total amount of the mixture, has a melting point below 100° C., (b) forcing the material through a pelletizing die, (c) carrying out die-face pelletization under water, (d) transporting the pelletized stabilizer mixture away in a stream of water, (e) extracting the pelletized stabilizer mixture from the water, and (f) drying the pelletized stabilizer mixture. The present invention further relates to pelletized stabilizer mixtures producible therefrom, and also to use of these.

Abstract: The invention relates to a stabilizer system comprising a thermal stabilizer and a supported, at least partly calcined dolomite of the formula Mt1X1*CaX2 where Mt1=Mg or Zn; X1=O or (OH)2; X2=O; (OH)2 or CO3, wherein the calcined dolomite has been supported with a metal perchlorate of the formula Mt2(ClO4)m*nH2O where Mt2=Li, Na, K, Mg, Ca, Ba, Zn, Al, La, Ce; m=1, 2 or 3, m being selected so as to compensate for the charge of the metal ion Mt2; n=0 to 3 and wherein the stabilizer system does not comprise any of the compounds selected from the group consisting of (B) and (C) when Mt1 is Mg, and wherein (B) at least one nitrogen-containing organic compound is selected from the group consisting of (B1) and (B2), (B1) being a tert-alkanolamine and (B2) being an enaminone or a urea, and (C) an alkaline earth metal aluminohydroxocarbonate of the formula (C) (M1?xZnx)yAl2(OH)4+2y CO3* zH2O (C) where M=magnesium or/and calcium; x=0 to 0.5; y=2 to 8 and z=0 to 12.

Abstract: A radially expandable system for the usage in body tubes is kept, by fixation of a first part and a second part relative to each other, in a second state in which the system exhibits a larger diameter compared to a first state. The fixation of the first part relative to the second part is performed by an adhesive. With the radially expandable system a body tube, for example a vein, can be assisted in its function. The first part and the second part can be arranged on or be formed by one single wall element or two different wall elements.

Abstract: The present invention relates to a process for producing a pelletized stabilizer mixture for halogen-containing plastics, comprising the following steps: (a) heating, at from 40 to 100° C. in an extruder or kneader, a mixture comprising (A) at least one lubricant, (B) at least one substance having stabilizer activity, and (C) auxiliaries and additives, ?where at least 1% by weight of all of the substances, based on the total amount of the mixture, has a melting point below 100° C., (b) forcing the material through a pelletizing die, (c) carrying out die-face pelletization under water, (d) transporting the pelletized stabilizer mixture away in a stream of water, (e) extracting the pelletized stabilizer mixture from the water, and (f) drying the pelletized stabilizer mixture. The present invention further relates to pelletized stabilizer mixtures producible therefrom, and also to use of these.

Abstract: The invention relates to a stabilizer system comprising a thermal stabilizer and a supported, at least partly calcined dolomite of the formula Mt1X1*CaX2 where Mt1=Mg or Zn; X1=O or (OH)2; X2=O; (OH)2 or CO3, wherein the calcined dolomite has been supported with a metal perchlorate of the formula Mt2(ClO4)m*nH2O where Mt2=Li, Na, K, Mg, Ca, Ba, Zn, Al, La, Ce; m=1, 2 or 3, m being selected so as to compensate for the charge of the metal ion Mt2; n=0 to 3 and wherein the stabilizer system does not comprise any of the compounds selected from the group consisting of (B) and (C) when Mt1 is Mg, and wherein (B) at least one nitrogen-containing organic compound is selected from the group consisting of (B1) and (B2), (B1) being a tert-alkanolamine and (B2) being an enaminone or a urea, and (C) an alkaline earth metal aluminohydroxocarbonate of the formula (C) (M1?xZnx)yAl2(OH)4+2y CO3* zH2O (C) where M=magnesium or/and calcium; x=0 to 0.5; y=2 to 8 and z=0 to 12.

Abstract: A radially expandable system (2) for the usage in body tubes is kept, by fixation of a first part (4) and a second part (6) relative to each other, in a second state (12) in which the system (2) exhibits a larger diameter 14 compared to a first state (8). The fixation of the first part (4) relative to the second part (6) is performed by an adhesive. With the radially expandable system (2) a body tube, for example a vein, can be assisted in its function. The first part (4) and the second part (6) can be arranged on or be formed by one single wall element (16) or two different wall elements (16, 16a, 16b).

Abstract: The present invention relates to a transcription factor of MHC class II genes and its derivatives, inhibitors down-regulating the expression of MHC class II molecules, process to identify these inhibitors and medical uses of these inhibitors.

Abstract: The present invention relates to a stabilizer composition for halogen-containing thermoplastic resins, the stabilizer composition comprising (a) calcium hydroxide and/or calcium oxide which may optionally be surface-modified; and (b) a hydroxyl group-containing isocyanurate. This stabilizer composition is particularly suited for weather-resistant halogen-containing resin compositions, such as rigid PVC.

Abstract: The present invention is a stabiliser composition for thermoplastic resin compositions, especially for resin compositions based on polyvinyl chloride (PVC), that comprises calcium hydroxide or calcium oxide or a mixture of calcium hydroxide and calcium oxide, at least one ?-diketone or a salt of a ?-diketone or a mixture thereof and at least one hydroxyl-group-containing isocyanurate or a mixture of two or more hydroxyl-group-containing isocyanurates, wherein component B contains less than 33% by weight, based on component B, of acetylacetone or a salt of acetylacetone or a mixture thereof.

Abstract: The invention relates to a stabilizer composition which comprises at least one calcium compound and one isocyanurate bearing hydroxy groups and also one dye or one pigment or both for weathering-resistant thermoplastic resin compositions, in particular for weathering-resistant colored resin compositions based on polyvinyl chloride—(PVC)—where the composition has low content of ?-diketones or is in essence free from ?-diketones.

Abstract: The present invention relates to a stabilizer composition for thermoplastic resin compositions, in particular for resin compositions based on polyvinyle chloride (PVC), that comprises calcium hydroxide or calcium oxide or a mixture thereof, at least one hydroxyl-group-containing isocyanurate and less than 0.5 phr of ?-diketones, based on the thermoplastic resin to be stabilized or the thermoplastic resins to be stabilized.

Abstract: The present invention relates to a transcription factor of MHC class II genes and its derivatives, inhibitors down-regulating the expression of MHC class II molecules, process to identify these inhibitors and medical uses of these inhibitors.

Abstract: The present invention relates to a transcription factor of MHC class II genes and its derivatives, inhibitors down-regulating the expression of MHC class II molecules, process to identify these inhibitors and medical uses of these inhibitors.

Abstract: A stabilizer combination for weathering-resistant-halogen-containing thermoplastic resin compositions, in particular those based on polyvinyl chloride (or PVC) is described, encompassing calcium chloride and/or calcium oxide with a particle size of not more than 200 ?m, an organotin compound and at least one zinc compound selected from liquid and solid zinc salts of saturated, unsaturated, straight-chain, or branched mono- or polyfunctional aromatic or aliphatic carboxylic acids, zinc oxide and zinc hydroxide, which contains no perchlorate.

Abstract: The present invention is directed to processes for the preparation of a processing aid for vinyl polymers, to processing aids prepared in accordance with the process of the invention and to polymer compositions comprising such processing aids.

Abstract: The present invention relates to a stabilizer composition for halogen-containing thermoplastic resins, the stabilizer composition comprising

Abstract: The present invention relates to a novel trancription factor of MHC class II genes and its derivatives, inhibitors down-regulating the expression of MHC class II molecules, process to identify these inhibitors and medical uses of these inhibitors.

Abstract: The present invention relates to a stabilizer composition for weather-resistant halogen-containing thermoplastic resin compositions, in particular based on PVC. The stabilizer composition according to the invention contains at least one natural or synthetic hydrotalcite, at least one basic calcium-aluminum-hydroxy compound, selected from basic calcium-aluminum-hydroxy-phosphites and basic calcium-aluminum-hydroxy-carboxylates, and at least one polyol and/or at least one hydroxy group-containing isocyanurate.

Abstract: A method for the production of a guide rail for linear guiding and having a hardened rolling body race groove on opposite sides of the guide rail. In order to minimize production costs and avoid cutting of the race grooves, the race grooves are initially spaced at a distance that is greater or smaller than their finally desired value, by an incremental distance. Grooves are provided centrally in the guide rail between the opposed race grooves, and the race rail is then hardened except in the region of the central grooves. Compression rollers in the race grooves or central grooves are then forced into the guide rail to decrease or increase respectively the distance between the race grooves until the desired distance therebetween is obtained. The method can also be employed when only a single race groove is provided on the rail.