Abstract: A composition includes co-polyamino acid bearing carboxylate charges and at least one hydrophobic radical -Hy that are chosen among the co-polyamino acids according to formula XXXb: wherein, D represents, independently, either a group —CH2— (aspartic acid) or a group —CH2—CH2— (glutamic acid), X represents a cationic entity chosen from the group comprising alkali cations, Rb and R?b, identical or different, are either a hydrophobic radical -Hy, or a radical chosen from the group consisting of an H, a C2 to C10 linear acyl group, a C3 to C10 branched acyl group, a benzyl, a terminal “amino acid” unit and a pyroglutamate, at least one of Rb and R?b is a hydrophobic radical -Hy, n+m represents the degree of polymerization DP of the co-polyamino acid, namely the mean number of monomeric units per co-polyamino acid chain and 5?n+m?250.

Abstract: The invention relates to a composition in the form of an injectable aqueous solution, wherein the pH is comprised from 6.0 to 8.0, comprising at least: a) amylin, an amylin receptor agonist or an amylin analog; b) a co-polyamino acid bearing carboxylate charges and hydrophobic radicals Hy, characterized in that the composition does not comprise a basal insulin wherein the isoelectric point pI is comprised from 5.8 to 8.5. It also relates to a composition characterized in that it further comprises a prandial insulin.

Abstract: A composition in the form of an injectable aqueous solution, wherein the pH is comprised from 6.0 to 8.0, includes at least: a) amylin, an amylin receptor agonist or an amylin analog; and b) a co-polyamino acid bearing carboxylate charges and hydrophobic radicals Hy, wherein the composition does not comprise a basal insulin wherein the isoelectric point pI is comprised from 5.8 to 8.5. The composition may further include a prandial insulin.

Abstract: Physically stable compositions in the form of an injectable aqueous solution, wherein the pH is from 6.0 to 8.0, includes at least: a) human glucagon and b) a co-polyamino acid bearing carboxylate charges and hydrophobic radicals Hy. In one embodiment, the compositions further comprise a gut hormone.

Abstract: A composition in the form of an injectable aqueous solution, wherein the pH is comprised from 6.0 to 8.0, includes at least: a) amylin, an amylin receptor agonist or an amylin analog; and b) a co-polyamino acid bearing carboxylate charges and hydrophobic radicals Hy, wherein the composition does not comprise a basal insulin wherein the isoelectric point pI is comprised from 5.8 to 8.5. The composition may further include a prandial insulin.

Abstract: Physically stable compositions in the form of an injectable aqueous solution, wherein the pH is from 6.0 to 8.0, includes at least: a) human glucagon and b) a co-polyamino acid bearing carboxylate charges and hydrophobic radicals Hy. In one embodiment, the compositions further comprise a gut hormone.

Abstract: In one embodiment, the composition according to the invention is characterized in that the co-polyamino acid bearing carboxylate charges and at least one hydrophobic radical -Hy is chosen among the co-polyamino acids according to formula XXXb hereinafter: wherein, D represents, independently, either a group —CH2— (aspartic acid) or a group —CH2—CH2— (glutamic acid), X represents a cationic entity chosen in the group comprising alkali cations, Rb and Rb?, identical or different, are either a hydrophobic radical -Hy, or a radical chosen in the group consisting of an H, a C2 to C10 linear acyl group, a C3 to C10 branched acyl group, a benzyl, a terminal “amino acid” unit and a pyroglutamate, at least one of Rb and R?b is a hydrophobic radical -Hy, Q and Hy are as defined above. n+m represents the degree of polymerization DP of the co-polyamino acid, namely the mean number of monomeric units per co-polyamino acid chain and 5?n+m?250.

Abstract: A sever with processor(s) and memory provides a user interface to a client device for presentation to a user including user interface objects corresponding to functions of an online application. The server obtains a user profile for the user, including performance metrics of the user and determines whether to provide informative materials to the client device based on the user profile. In accordance with a determination that the informative materials are to be superimposed on the user interface, the server: determines a portion of the informative materials to be provided to the client device based on the performance metrics of the user; and provides the portion of the informative materials to the client device for presentation to the user, including media content overlaid on the user interface. The server responds to user interaction with any of the user interface objects by performing corresponding functions of the online application.

Abstract: A sever with processor(s) and memory provides a user interface to a client device for presentation to a user including user interface objects corresponding to functions of an online application. The server obtains a user profile for the user, including performance metrics of the user and determines whether to provide informative materials to the client device based on the user profile. In accordance with a determination that the informative materials are to be superimposed on the user interface, the server: determines a portion of the informative materials to be provided to the client device based on the performance metrics of the user; and provides the portion of the informative materials to the client device for presentation to the user, including media content overlaid on the user interface. The server responds to user interaction with any of the user interface objects by performing corresponding functions of the online application.

Abstract: An electronic device with one or more processors and memory provides a user interface for presentation to a user including a plurality user interface objects corresponding to functions of an online application. The device determines whether to superimpose a portion of the informative materials on the user interface. In accordance with a determination that the portion of the informative materials is to be superimposed on the user interface, the device provides the portion of the informative materials for presentation to the user, including: media content overlaid on the user interface; and a focus indicator overlaid on the user interface that is configured to draw the respective user's attention to one or more user interface objects of the user interface in coordination with the media content. The device responds to user interaction with a user interface objects by performing a corresponding function of the online application.