Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: Exhibiting favorable attributes of both a regular slotted container (“RSC”) and an automatic bottom container, a sheet material container is quickly and easily erectable from a knocked-down-flat (“KDF”) container precursor. The precursor collapses to a uniform two-layer KDF condition which permits stable, even stacking of multiple precursors for bulk shipping and storage of the same. The precursor is formed from a blank including a plurality of wall panels hingedly attached to each other along fold lines to form a closed loop of wall panels, and a plurality of end flap panels hingedly attached along fold lines to ends of the respective wall panels. A pair of adjacent end flap panels lie in face-to-face relation with each other in the KDF condition. One of the adjacent pairs of panels has a diagonal fold line defining a corner attachment region that attaches to the other end flap panel.