Patents by Inventor Walter S. Willett

Walter S. Willett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glycopegylated granulocyte colony stimulating factor
    Patent number: 9029331
    Abstract: The invention relates to methods of preparing and purifying conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are purified using various chromatography methods.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: May 12, 2015
    Assignee: Novo Nordisk A/S
    Inventors: Shawn DeFrees, Henrik Clausen, David A. Zopf, Caryn Bowe, Susann Taudte, Michael Felo, Walter S. Willett
  • GLYCOPEGYLATED FACTOR VII AND FACTOR VIIA
    Publication number: 20090305967
    Abstract: The present invention provides conjugates between Factor VII or Factor VIIa peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
    Type: Application
    Filed: August 21, 2006
    Publication date: December 10, 2009
    Applicant: Novo Nordisk A/S
    Inventors: Shawn DeFrees, David A. Zopf, Susann Taudte, Walter S. Willett, Mattew Kalo, Robert J. Bayer
  • Glycopegylated Granulocyte Colony Stimulating Factor
    Publication number: 20090203579
    Abstract: The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
    Type: Application
    Filed: January 10, 2006
    Publication date: August 13, 2009
    Inventors: Shawn Defrees, Henrik Clausen, David A. Zopf, Caryn Bowe, Susann Taudte, Michael Felo, Walter S. Willett