Patents by Inventor Walter Sabel

Walter Sabel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for isolating insulin by high-pressure liquid chromatography
    Patent number: 5977297
    Abstract: A process for isolating insulin which entails performing high-pressure liquid chromatography with pressure-stable acidic cation exchange material under a pressure of from 1.1 MPa to 40 MPa.
    Type: Grant
    Filed: December 17, 1997
    Date of Patent: November 2, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Rainer Obermeier, Jurgen Ludwig, Walter Sabel
  • Process for obtaining insulin having correctly linked cystine bridges
    Patent number: 5663291
    Abstract: A process for obtaining insulin having correctly linked cystine bridges from a corresponding proinsulin amino acid chain in the presence of mercaptan, chaotropic auxiliaries and at a pH of 10 to 11 is described, as well as the direct conversion of the proinsulin to insulin with the aid of enzymes and direct isolation of the insulin from the reaction mixture with the aid of hydrophobic adsorber resins.
    Type: Grant
    Filed: February 16, 1995
    Date of Patent: September 2, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Rainer Obermeier, Martin Gerl, Jurgen Ludwig, Walter Sabel
  • Process for obtaining proinsulin possessing correctly linked cystine bridges
    Patent number: 5473049
    Abstract: A process is described for obtaining proinsulin possessing correctly linked cystine bridges from a corresponding proinsulin amino acid chain in the presence of mercaptan and chaotropic auxiliary agents and at a pH of 10 to 11, as well as its direct isolation from the reaction mixture using hydrophobic adsorber resins.
    Type: Grant
    Filed: December 1, 1993
    Date of Patent: December 5, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Rainer Obermeier, Martin Gerl, Jurgen Ludwig, Walter Sabel
  • Amorphous monospheric forms of insulin derivatives
    Patent number: 5466666
    Abstract: A process for the production of an amorphous monospheric form of insulin derivatives is described, wherein the insulin derivative is dissolved in an n-propanol/buffer mixture at a pH of 4.5 to 6.5, an n-propanol content of more than 13% relative to water is established and the resulting solution is subsequently diluted with water.
    Type: Grant
    Filed: April 25, 1994
    Date of Patent: November 14, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Rainer Obermeier, Walter Sabel, Peter Deil, Karl Geisen