Abstract: The invention relates to a method for examining a human or animal cell specimen, comprising the steps: a) providing at least one combinatorial cluster (CMP) which is characteristic of a disease, the CMP characterizing the colocalization and/or anticolocalization of multiple biological features in a voxel; b) determining N tags which are sufficient to determine CMP; c) bringing the cell specimen into contact with the N tags; d) measuring the cell specimen by means of flow cytometry to obtain flow cytometric data; and e) using the flow-cytometric data to check whether the CMP occurs in the cell. The invention further relates to a flow cytometer (10).

Abstract: The invention relates to a method for the extracorporeal removal of pathogens and/or an excess of components from a cell sample of a human or animal patient suffering from an illness. The method comprises the steps: a) determination of at least one protein cluster (CMP) that is characteristic of the illness of the patient; b) preparation of the cell sample of the patient; and c) extracorporeal removal of components having the at least one determined protein cluster from the cell sample. The invention further relates to a device for carrying out said method.

Abstract: Apparatus for measurement of the reception time of a pulse in a receiving system, which contains at least one receiving channel with a non-linear transmission response, which receiving channel produces at its output a received signal, having a memory, in which the received signals of reference pulses with a predetermined different amplitude are available as reference signals with respect to a time scale, and having an evaluation device, which is connected to the receiving system and to the memory and compares a received signal with each reference signal with a variant time offset in order to determine that reference signal and that time offset for which the comparison discrepancy is a minimum, and outputs this time offset as the reception time with respect to the time scale.

Abstract: The invention relates to a method for identifying prostate cancer in a patient that includes at least the step of examining if at least a protein cluster (CMP) or a group of CMPs containing at least CD26 and CD29 can be identified on the cell surfaces of cells from a part of the body of the patient, wherein the part of the body is prostate tissue and is suspected to be affected by prostate cancer.

Abstract: The invention relates to a method for treating a cancerous and/or an inflammatory disease in a patient, comprising internally administering to the patient an effective amount of a pharmaceutical preparation blocking the biological activity of at least one protein cluster (CMP) or group of CMPs containing at least CD26 and/or CD29. The invention also relates to a pharmaceutical composition for the treatment of a cancerous and/or an inflammatory disease in a patient, a method for identifying a cancerous and/or an inflammatory disease in a patient, a method of identifying at least one candidate for development of anti-cancerous or anti-inflammatory agents, a use of an antibody for preparing a pharmaceutical preparation or medicament for the treatment of prostate cancer, a composition or kit comprising at least one antibody and/or at least one ligand, and a biochip.

Abstract: Apparatus for measurement of the reception time of a pulse in a receiving system, which contains at least one receiving channel with a non-linear transmission response, which receiving channel produces at its output a received signal, having a memory, in which the received signals of reference pulses with a predetermined different amplitude are available as reference signals with respect to a time scale, and having an evaluation device, which is connected to the receiving system and to the memory and compares a received signal with each reference signal with a variant time offset in order to determine that reference signal and that time offset for which the comparison discrepancy is a minimum, and outputs this time offset as the reception time with respect to the time scale.

Abstract: The invention relates to a method for preparing biological samples for analysis, comprising the following steps: (a) the biological sample is placed on a two-dimensional support; (b) application of a protein-precipitating or denaturing first solution L1 to the biological sample at a first temperature T1 for a predetermined first time period Z1; (c) the protein-precipitating or denaturing first solution L1 is then left, or more solution is applied to the biological sample or a protein-precipitating or denaturing second solution L2 is applied to the biological sample at a temperature T2, for a predetermined second time period Z2, whereby T2 is lower than T1 and Z2 is longer, equal to or shorter than Z1; and (d) drying of the sample.

Abstract: The invention relates to a method for detection of a disease-specific combinatorial molecular pattern motif in a tissue sample of a patient's skin and/or a tissue sample of skin-neighboured-mucosa, wherein the spatial arrangement of epitopes in the sample is captured for identifying the disease-specific combinatorial molecular pattern motif. The invention moreover relates to compositions and kits comprising antibodies and/or ligands which can be employed for the performance of the method.

Abstract: The invention relates to a method for identification of somatic stem cells, wherein the spatial arrangement of epitopes in a sample is captured by MELC technology for identifying the phenotype specific to the somatic stem cells. The invention moreover relates to a composition, a kit and a biochip comprising at least one antibody and/or ligand which can be employed for the performance of the method.

Abstract: The present invention relates to a method for identifying cell-specific proteins comprising the following steps: a) determining cell-specific protein combination patterns of n cells; b) comparing the protein combination patterns of healthy and pathologically or physiologically modified cells of one cell type or comparing the protein combination patterns of cells of a different cell type affected by the same disease; c1) subtracting the coincident parts of the protein combination patterns of healthy and pathologically or physiologically modified cells of one cell type compared in step b) and determining a cell-specific protein resulting therefrom; or c2) subtracting the non-coincident parts of the protein combination patterns of cells of a different cell type affected by the same disease compared in step b) and determining a cell-specific protein resulting therefrom; and d) identifying the resulting cell-specific protein in terms of molecules and spatial structure.

Abstract: The present invention discloses a method for identifying cell-specific protein combination patterns of cell surfaces of circulating cells of the immune system of a human or animal for the identification of different stages of organ-specific chronic inflammatory diseases or tumour diseases comprising the following steps: a) providing a sample of circulating cells of the immune system of a human or animal showing an organ-specific chronic inflammatory disease or tumour disease and providing a sample of circulating cells of the same cell type of the immune system of a healthy human or animal; b) determining cell-specific protein combination patterns of the cell surfaces of said healthy and pathologically modified cells; c) comparing the resulting protein combination patterns of the cell surfaces of said healthy and pathologically modified cells and subtracting the coincident parts of the protein combination patterns of said healthy and pathologically modified cells, thereby determining a cell-specific protein co

Abstract: The invention relates to a method for the automatic analysis of microscope images of biological objects such as, for example, fluorescence images of cells, comprising: a) at least two microscope images are taken from a sample; b) a positive training set is determined from image excerpts; c) a negative training set is determined from a sequence of image excerpts; d) characteristic features of a training set are assigned to classification values; e) classification values of a sequence of images are automatically determined by means of the assignment determined in d); f) the position of biological objects is recognized by comparing the classification value with a threshold value.

Abstract: The invention relates to a method for identification of somatic stem cells, wherein the spatial arrangement of epitopes in a sample is captured by MELC technology for identifying the phenotype specific to the somatic stem cells. The invention moreover relates to a composition, a kit and a biochip comprising at least one antibody and/or ligand which can be employed for the performance of the method.

Abstract: The invention relates to a method for detection of a disease-specific combinatorial molecular pattern motif in a tissue sample of a patient's skin and/or a tissue sample of skin-neighboured-mucosa, wherein the spatial arrangement of epitopes in the sample is captured for identifying the disease-specific combinatorial molecular pattern motif. The invention moreover relates to compositions and kits comprising antibodies and/or ligands which can be employed for the performance of the method.

Abstract: The invention concerns the utilization of at least one aminopeptidase inhibitor for the production of a medicament used in the treatment of tumor diseases and/or immune diseases, whereby the at least one aminopeptidase inhibitor causes blocking of polarization of invasive human or animal tumor and/or immune cells by modifying at least one surface protein CD13 as member of a protein network on the surface of the tumor and/or immune cells, whereby the protein network comprises up to 30 surface proteins from a defined group. The invention also concerns a pharmaceutical preparation and a method for identifying at least one additional inhibitor acting in combination with the at least one aminopeptidase inhibitor.

Abstract: This invention relates to a process for identifying and enriching cell-specific target structures, in particular for the identification of cell-specific protein combination patterns on the surface of cells and for enriching such cells. The process comprises depositing a heterogeneous cell mixture one or plural surfaces with predefined structures causing cells with corresponding target structures to become bound to such surface(s), removing any non-binding cells of said cell mixture from said surface, identifying the cell-specific target structures responsible for the binding of the cells to said surface(s), selecting and enriching cells with identical cell-specific target structures on said surface(s), and biochemically characterizing the target structures.

Abstract: The present invention relates to a device for binding molecules, molecular groups, molecular parts and/or cells contained in a liquid to target structures, the device having at least one object holder with at least one target structure firmly held therein and which contacts at least one duct made of at least one material. One aperture of the duct is a liquid inlet aperture, and a second aperture is a liquid outlet aperture. At least one object holder thermostat is used for cooling the object holder.

Abstract: This invention relates to a process for identifying cell-specific target structures. The process comprises automatically depositing a reagent solution that includes at least one marker molecule on an object which contains cells and/or cell membranes originating from a cell or tissue sample, allowing the reagent solution to react and automatically detecting at least one marker pattern of the object labeled with the reagent solution, removing said reagent solution, combining detected marker patterns, repeating the process with at least one further object, determining at least one difference in the objects, identifying at least one reagent solution causing the at least one difference, selecting molecules or molecular complexes from a homogenate of cells and/or cell membranes, and biochemically characterizing these molecules or molecular complexes.

Abstract: The present invention relates to a device for binding molecules, molecular groups, molecular parts and/or cells contained in a liquid to target structures, the device having at least one object holder with at least one target structure firmly held therein and which contacts at least one duct made of at least one material. One aperture of the duct is a liquid inlet aperture, and a second aperture is a liquid outlet aperture. At least one object holder thermostat is used for cooling the object holder.

Abstract: Coating agents with resin solids of