Abstract: The present invention relates to compounds for stabilising the native tetrameric form of transthyretin and protecting it from proteolytic cleavage; compounds for use in the prevention and treatment of transthyretin amyloidosis; and agents and medicaments comprising such compounds. The compounds are based on a general structure A-L-B, wherein A is a group of formula (II) or of formula (III): or of formula (IV) or of formula (V) B is a group of formula (III), (IV), or (V), or a group of formula (VI) or a group of formula —R10Z, wherein: Z is selected from —CO2R?, —CONR?R?, —SO2R? wherein R? and R? are independently H or C1-C4 alkyl; and R10 is a C1-C4 alkylene or alkenylene group; and L represents a linker group which is a saturated or unsaturated chain of 5 to 13 carbon atoms.

Abstract: The invention comprises an agent for use in medicine, wherein the agent comprises a compound of Formula (I): B-L-B? wherein: B and B? are independently selected from groups of formula (B-I) wherein: Z is selected from —COOH, —CH2COOH, —PO(OH)(OR1), or —CH2PO(OH) (OR1), wherein R1 is H or a phosphate protecting group; W is an alicyclic amine group having from 5 to 12 carbon atoms and at least one amine nitrogen atom; W? is H, or W? is linked to W to form said alicyclic amine group; and Y is selected from —NH—, —N(CH3)—, —CH2—, —NHCO—, —CH2CONH—, —CONH—, CH2NHCO—, or —NHCH2—; and L is a linker group.

Abstract: An agent for use in medicine, wherein the agent comprises a compound of Formula (I): wherein Ar is an aryl linker group, for example a 1,4-phenyl group, including individual pharmaceutically acceptable salts, solvates, prodrugs or derivatives thereof. The compounds of Formula (I) are inhibitors of human C-reactive protein (CRP) and may be used for the treatment of medical conditions mediated by CRP. Also provided are methods of making the compounds of Formula (I) and chemical intermediates thereof.

Abstract: The present disclosure provides various embodiments of a combustion-powered-fastener-driving tool that include a lockout device to ensure the tool's valve sleeve doesn't move to an unsealed position and the tool's combustion chamber remains sealed until the piston returns to the pre-firing position. The lockout device is engageable with a lockout device engaging member operably connected to the tool's trigger, which gives the operator direct control over locking the valve sleeve in the unsealed position.

Abstract: Various embodiments of the present disclosure provide a combustion powered fastener driving tool including a fuel cell receiver configured to receive and engage a fuel cell metering valve of a fuel cell, the fuel cell metering valve configured to dispense a dose of fuel from the fuel cell.

Abstract: Various embodiments of the present disclosure provide a combustion powered fastener driving tool including a fuel cell receiver configured to receive and engage a fuel cell metering valve of a fuel cell, the fuel cell metering valve configured to dispense a dose of fuel from the fuel cell.

Abstract: The present disclosure provides various embodiments of a combustion-powered-fastener-driving tool that include a lockout device to ensure the tool's valve sleeve doesn't move to an unsealed position and the tool's combustion chamber remains sealed until the piston returns to the pre-firing position. The lockout device is engageable with a lockout device engaging member operably connected to the tool's trigger, which gives the operator direct control over locking the valve sleeve in the unsealed position.

Abstract: The present disclosure provides various embodiments of a combustion-powered-fastener-driving tool that include a lockout device to ensure the tool's valve sleeve doesn't move to an unsealed position and the tool's combustion chamber remains sealed until the piston returns to the pre-firing position. The lockout device is engageable with a lockout device engaging member operably connected to the tool's trigger, which gives the operator direct control over locking the valve sleeve in the unsealed position.

Abstract: A choke for fluid connection between a manifold and a pump. The choke includes a fluid passage having an inlet, a contraction portion, a throat, an expansion portion, and an outlet. The inlet has a first diameter and the outlet has a second diameter. The throat is substantially cylindrical, having a third diameter that is substantially less than the first and second diameters. The contraction portion connects the inlet and the throat and gradually decreases from the first diameter to the third diameter along a longitudinal axis of the fluid passage. The expansion portion connects the throat and the outlet and includes a substantially cylindrical chamber having the second diameter.

Abstract: Various embodiments of the present disclosure provide a combustion powered fastener driving tool including a fuel cell receiver configured to receive and engage a fuel cell metering valve of a fuel cell, the fuel cell metering valve configured to dispense a dose of fuel from the fuel cell.

Abstract: The present disclosure provides various embodiments of a combustion-powered-fastener-driving tool that include a lockout device to ensure the tool's valve sleeve doesn't move to an unsealed position and the tool's combustion chamber remains sealed until the piston returns to the pre-firing position. The lockout device is engageable with a lockout device engaging member operably connected to the tool's trigger, which gives the operator direct control over locking the valve sleeve in the unsealed position.

Abstract: A choke for fluid connection between a manifold and a pump. The choke includes a fluid passage having an inlet, a contraction portion, a throat, an expansion portion, and an outlet. The inlet has a first diameter and the outlet has a second diameter. The throat is substantially cylindrical, having a third diameter that is substantially less than the first and second diameters. The contraction portion connects the inlet and the throat and gradually decreases from the first diameter to the third diameter along a longitudinal axis of the fluid passage. The expansion portion connects the throat and the outlet and includes a substantially cylindrical chamber having the second diameter.

Abstract: The current application discloses various embodiments where a portion of a fluid end pump body is made of a first material the other parts of the pump body are made of a second material where the first material is a material having better resistance to fatigue and the second material used is a material of less quality and cheaper than the first material.

Abstract: A pump assembly having a power end and a fluid end, wherein the fluid end includes a plurality of pump bodies connected side by side between opposing end plates with a plurality of fasteners tightened to compress the pump bodies between the end plates. The power end and at least one of the plurality of pump bodies being connected together by a tie rod having a rod portion and a sleeve portion, wherein the sleeve portion surrounds the rod portion and abuts the power end at an end and at least one of the pump bodies of the fluid end at an opposite end.

Abstract: An automated external defibrillator (AED) and methods for a corrective CPR prompting system. The AED includes a sensor that obtains compression measurement data of CPR chest compressions and a control system including a microprocessor programmed to run a non-parametric, Information-Theoretic analysis of the compression measurement data. The analysis includes ranking provided compression measurement data, determining a prompt time TN for review, locating the compression measurement data at TN in an initial expected histogram of depth and rate aspects of the compression data measurements with upper and lower limits, that divides the intervals of the histogram into a plurality of sections, weighting the compression measurement data based on a plurality of factors, deriving information content of the compression measurement data by mapping a probability density function into an information content function, and determining if a particular corrective prompt is necessary.

Abstract: A multiplex fluid pump assembled from a plurality of pump bodies connected side by side between opposing end plates with a plurality of fasteners tightened to compress the pump bodies between the end plates. Raised surfaces on opposite exterior side surfaces of each pump body are engaged with an adjacent end plate or an adjacent pump body to apply a pre-compressive force at the raised surfaces and thereby inhibit the initiation of fatigue cracks.

Abstract: A device and method for recommending an initial treatment of either a defibrillation shock or CPR for a cardiac arrest victim. An embodiment of the invention is directed to an AED with treatment protocols selected from a set of external defibrillation, CPR, or a combination thereof. The AED includes a power generation circuit, pair of external electrodes, and an ECG sensor. AED further includes a control system including a microprocessor configured to determine a survivability index number for a patient and recommend a treatment protocol using the AED as well as a communication system configured to communicate the selected protocol to a user of the AED.

Abstract: An automated external defibrillator (AED) and methods for a corrective CPR prompting system. The AED includes a sensor that obtains compression measurement data of CPR chest compressions and a control system including a microprocessor programmed to run a non-parametric, Information-Theoretic analysis of the compression measurement data. The analysis includes ranking provided compression measurement data, determining a prompt time TN for review, locating the compression measurement data at TN in an initial expected histogram of depth and rate aspects of the compression data measurements with upper and lower limits, that divides the intervals of the histogram into a plurality of sections, weighting the compression measurement data based on a plurality of factors, deriving information content of the compression measurement data by mapping a probability density function into an information content function, and determining if a particular corrective prompt is necessary.