Patents by Inventor Walter Urba

Walter Urba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Short-term anti-CD3 stimulation of lymphocytes to increase their in vivo acitivity
    Patent number: 5316763
    Abstract: The present invention is directed to a method of increasing the in vivo immune response of lymphocytes by stimulating the lymphocytes in vitro in the presence of an anti-CD3 monoclonal antibody for less than about 24 hours to form stimulated lymphocytes; infusing the stimulated lymphocytes into a tumor-bearing mammal; and administering IL-2 to the mammal. As a result of this method, the anti-CD3 stimulated lymphocytes display enhanced immunotherapeutic, e.g., cytotoxicity or lymphokine production, in vivo as represented by a decrease in the number of tumors by at least about 20%.
    Type: Grant
    Filed: July 10, 1992
    Date of Patent: May 31, 1994
    Assignees: The United States of America as represented by the Department of Health and Human Services, Regents of the University of Minnesota
    Inventors: Augusto C. Ochoa, Cynthia Loeffler, Walter Urba, Dan L. Longo