Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: A system and method for simulating a transportation network is disclosed herein. A simulation may be configured at a configuration application, which enables designers and hyperloop operators to enter real-world constraints as alignment data. A plurality of travel scenarios may be run in order to generate simulated run results. An analytics engine may perform analysis on the simulated run results in order to inform designers and hyperloop operators seeking to improve the transportation network. A prediction modeler may be utilized to predict events occurring in the transportation network as simulated. Parallel processing may be utilized to increase the efficiency and speed of the simulation. The simulation may be performed before, during, and after the implementation of the transportation network.

Abstract: Some embodiments provide a program. The program receives a visualization collection definition specifying a plurality of visualization definitions for a plurality of visualization definitions. Each visualization definition in the plurality of visualization definitions specifies a multi-dimensional array of data definition. The program further identifies a set of multi-dimensional array of data definitions specified in the plurality of visualization definitions of the visualization collection definition. The program also sends a request for the set of multi-dimensional array of data definitions to a computing system. The program further receives the set of multi-dimensional array of data definitions from the computing system. The program also stores the set of multi-dimensional array of data definitions in a cache storage of the mobile device for later use.

Abstract: A solution is disclosed that is related to the supervised operation of an autonomous hyperloop network. The disclosed solution provides for a hybrid approach to managing an autonomous network wherein human-based and computer-based commands may be send to a plurality of hyperloop pods in order to provide safety and efficiency for the hyperloop network. Issues may be presented to human operators such that actions may be taken to address the issues. Additionally, recommendations as to which action to take may be presented to the human operator via a user interface. The human operator may define a set of global restrictions and operational parameters as a policy that constrains the operations of the hyperloop pods within the hyperloop network.

Abstract: A system for design, modeling, simulation, and analysis of transportation systems is described herein. The system may obtain a set of configuration data for a set of transportation systems. The system may generate a set of models for the set of transportation systems based on the set of configuration data. The system may simulate operations of the proposed transportation system and the one or more other transportation systems based the set of models. The system may also obtain a set of performance metrics for the set of transportation systems based on the simulation.

Abstract: According to one embodiment, a system in response to a request to back up a virtual machine to a backup storage system, generates a snapshot of the virtual machine. The system identifies one or more files within the snapshot that satisfy a predetermined criterion. If the one or more files are identified, the storage system backs up a modified representation of the snapshot by, analyzing the snapshot to determine addresses of the identified one or more files within the snapshot, and substituting content of the identified one or more files at the addresses with a predetermined data pattern. The system deduplicates the modified representation of the snapshot to remove duplicated data segments and copies data segments of the modified representation of the snapshot to the backup storage system such that data segments to be copied to the backup storage system is minimized.

Abstract: A filter assembly for filtering an exhaust gas and preventing contaminates from reaching a medical sampling instrumentation. The filter assembly comprises a hydrophobic filter media component; a first enclosure with an inlet (second) port communicating with an inwardly facing surface carrying a plurality of first channels, a first annular sidewall surrounding the first channels, and the first annular sidewall carrying a first mating feature at a free end thereof; a second enclosure having an outlet (first) port which communicating with an inwardly facing surface carrying a plurality of second channels, and a second mating feature surrounding the second channels. The first and second enclosures matingly engaging with one another so that the first and the second mating features mate with one another and the first and second enclosures define a filter chamber therebetween which captively retains the hydrophobic filter media component within the filter chamber having minimal dead space.

Abstract: One example includes an autonomous vehicle control system. The system includes an operational plan controller to maintain operational plans that each correspond to a predetermined set of behavioral characteristics of an associated autonomous vehicle based on situational awareness data provided from on-board sensors of the autonomous vehicle and mission control data provided from a user interface. The system also includes a decision-making algorithm to select one of the operational plans for operational behavior of the autonomous vehicle based on the situational awareness data and the mission control data at a given time and to provide an intent decision based on the situational awareness data and the selected one of the operational plans. The system further includes an execution engine to provide control outputs to operational components of the autonomous vehicle for navigation and control based on the selected one of the operational plans and in response to the intent decision.

Abstract: An exemplary system for correcting a spinal deformity includes a plurality of transverse rods, a longitudinal rod, and at least one node. The plurality of transverse rods each includes a first end for coupling with an extension member of a spinal fixation system and a second end. The longitudinal rod extends transverse to the transverse rods. The at least one node receives the second ends of first and second transverse rods and the longitudinal rod within a receiving portion and an adjustment member selectively secures the second ends.

Abstract: A ready to assemble or knockdown sofa having a back rest that can be reconfigured between a use configuration in which the sofa is has a conventional L-shaped cross-section and a shipping or storage configuration in which the sofa is arranged in a more efficiently stacked rectangular cross-section. The rectangular cross-section allows the sofa to be more efficiently stacked with other sofas during shipping or storage. The back rest has an upper back rest portion and a lower back rest portion in which the upper back rest portion can be rotated forward toward the front of the sofa and downwardly into a nesting region against the top of the seat base to provide a more efficient shape.

Abstract: Described are techniques for processing a write operation that writes first data to a target location of a logical address range of a logical device. It is determined whether the target location is mapped to physical storage. Responsive to determining that the target location is not mapped to physical storage, performing first processing to service the write operation. The first processing includes sending the write operation along with a hint to a caching layer where the hint indicates to store zeroes to locations that do not include user data. The caching layer forms a data portion denoting data stored at a logical address subrange of the logical device. The logical address subrange includes the target location. The data portion includes the first data and zeroes stored at remaining locations of the logical address subrange not including user data. The data portion is stored in cache by the caching layer.

Abstract: An exemplary system for correcting a spinal deformity includes a plurality of transverse rods, a longitudinal rod, and at least one node. The plurality of transverse rods each includes a first end for coupling with an extension member of a spinal fixation system and a second end. The longitudinal rod extends transverse to the transverse rods. The at least one node receives the second ends of first and second transverse rods and the longitudinal rod within a receiving portion and an adjustment member selectively secures the second ends.

Abstract: Described are techniques for updating checkpoint data during a copy process that copies data from a first device to a second device. A portion of data is copied from the first device to the second device. A first calculated value is determined in accordance with a plurality of factors. In accordance with the first calculated value and a threshold ratio, it is determined whether to update the checkpoint data denoting progress of the copying process that copies data from the first device to the second device. If it is determined to update the checkpoint data, first processing is performed that updates the checkpoint data.

Abstract: One example includes an autonomous vehicle control system. The system includes an operational plan controller to maintain operational plans that each correspond to a predetermined set of behavioral characteristics of an associated autonomous vehicle based on situational awareness data provided from on-board sensors of the autonomous vehicle and mission control data provided from a user interface. The system also includes a decision-making algorithm to select one of the operational plans for operational behavior of the autonomous vehicle based on the situational awareness data and the mission control data at a given time and to provide an intent decision based on the situational awareness data and the selected one of the operational plans. The system further includes an execution engine to provide control outputs to operational components of the autonomous vehicle for navigation and control based on the selected one of the operational plans and in response to the intent decision.

Abstract: One embodiment includes a simulation system for an autonomous vehicle. The simulation system includes a user interface configured to facilitate user inputs comprising spontaneous simulated events in a simulated virtual environment during simulated operation of the autonomous vehicle via an autonomous vehicle control system. The system also includes a simulation controller configured to generate simulated sensor data based on model data and behavioral data associated with each of the simulated virtual environment and the spontaneous simulated events. The simulated sensor data corresponds to simulated sensor inputs provided to the autonomous vehicle control system via sensors of the autonomous vehicle. The simulation controller is further configured to receive simulation feedback data from the autonomous vehicle control system corresponding to simulated interaction of the autonomous vehicle within the simulated virtual environment.

Abstract: A ready to assemble or knockdown sofa having a back rest that can be reconfigured between a use configuration in which the sofa is has a conventional L-shaped cross-section and a shipping or storage configuration in which the sofa is arranged in a more efficiently stacked rectangular cross-section. The rectangular cross-section allows the sofa to be more efficiently stacked with other sofas during shipping or storage. The back rest has an upper back rest portion and a lower back rest portion in which the upper back rest portion can be rotated forward toward the front of the sofa and downwardly into a nesting region against the top of the seat base to provide a more efficient shape.

Abstract: A component interface assembly for attaching the individual subcomponents of an RTA furniture system. Each component interface assembly having an elongated alignment slot cut into one of the subcomponents of the RTA furniture kit and a retention element affixed to a second corresponding subcomponent such that the first and second subcomponents can be secured together by inserting the retention element into the alignment slot. The alignment slot is positioned on the first subcomponent such that positioning the retention element for insertion into the slot aligns the second subcomponent with the first subcomponent providing tool-less alignment and engagement of the subcomponents. The assembled components may have cutouts on confronting planar surfaces of the respective first and second subcomponents providing enhanced storage for shipping the RTA furniture components.

Abstract: A ready to assemble or knockdown sofa having a back rest that can be reconfigured between a use configuration in which the sofa has a conventional L-shaped cross-section and a shipping or storage configuration in which the sofa is arranged in a more efficiently stacked rectangular cross-section. The rectangular cross-section allows the sofa to be more efficiently stacked with other sofas during shipping or storage. The back rest has an upper back rest portion and a lower back rest portion in which the upper back rest portion can be rotated forward toward the front of the sofa and downwardly into a nesting region against the top of the seat base to provide a more efficient shape.

Abstract: An exemplary system for correcting a spinal deformity includes a plurality of transverse rods, a longitudinal rod, and at least one node. The plurality of transverse rods each includes a first end for coupling with an extension member of a spinal fixation system and a second end. The longitudinal rod extends transverse to the transverse rods. The at least one node receives the second ends of first and second transverse rods and the longitudinal rod within a receiving portion and an adjustment member selectively secures the second ends.

Abstract: A limited angulation bone screw assembly adapted to couple a spinal rod with a vertebra including a bone screw, a bushing and a housing. The pedicle screw having a shaft and an upper head portion, the upper head portion comprising a spherical surface with flats disposed on opposite sides of the upper head portion. The bushing comprising a lower rounded surface for mating with the spherical surface and flats of the upper head portion to restrict the angular movement of the bone screw. The coupled bone screw and bushing are inserted into the housing in a first orientation and then rotated to a second orientation to secure the coupled bone screw and bushing to complete the housing.