Patents by Inventor Walter Weichel

Walter Weichel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8580547
    Abstract: The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) which have an increased substrate specificity compared with the wild type, and also to methods for production and identification thereof.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: November 12, 2013
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Walter Weichel, Volker Möhrle, Markus Schindler, Rainhard Koch, Rolandas Meskys
  • Publication number: 20110236920
    Abstract: The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) which have an increased substrate specificity compared with the wild type, and also to methods for production and identification thereof.
    Type: Application
    Filed: June 17, 2009
    Publication date: September 29, 2011
    Inventors: Walter Weichel, Volker Möhrle, Markus Schindler, Rainhard Koch, Rolandas Meskys
  • Publication number: 20090087874
    Abstract: The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) from Acinetobacter and to a process for their preparation by overexpression in suitable microbial expression systems.
    Type: Application
    Filed: October 6, 2008
    Publication date: April 2, 2009
    Applicant: BAYER TECHNOLOGY SERVICES GMBH
    Inventors: Ruth MEISSNER, Walter WEICHEL, Rainhard KOCH, Irina BACHMATOVA, Liucija MARCINKEVICIENE, Rita MESKIENE, Rasa SEMENAITE, Vida CASAITE, Rolandas MESKYS
  • Patent number: 7432096
    Abstract: The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) from Acinetobacter and to a process for their preparation by overexpression in suitable microbial expression systems.
    Type: Grant
    Filed: April 27, 2004
    Date of Patent: October 7, 2008
    Assignee: Bayer Technology Services GmbH
    Inventors: Ruth Meissner, Walter Weichel, Rainhard Koch, Irina Bachmatova, Liucija Marcinkeviciene, Rita Meskiene, Rasa Semenaite, Vida Casaite, Rolandas Meskys
  • Publication number: 20060263838
    Abstract: The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) from Acinetobacter and to a process for their preparation by overexpression in suitable microbial expression systems.
    Type: Application
    Filed: April 27, 2004
    Publication date: November 23, 2006
    Applicant: Bayer Technology Services GmbH
    Inventors: Ruth Meissner, Walter Weichel, Rainhard Koch, Irina Bachmatova, Liucija Marcinkeviciene, Rita Meskiene, Rasa Semenaite, Vida Casaite, Rolandas Meskys
  • Patent number: 6713264
    Abstract: The process is used for the screening of molecules from molecule libraries with regard to their individual binding behavior towards at least one given ligand. For this purpose the ligands labelled with a fluorescent dye are mixed with the molecule library which is in the form of a suspension. The mixture is plated out on a two-dimensional substrate (2) after the excess, unbound ligands have been washed out. Then the local fluorescence intensities on the substrate are electro-optically identified in a fluorescence microscope (5) and electronically discriminated in accordance with given selection criteria. The objects selected and localised in this way are then sequentially positioned exactly by a displacement, the coordinates of which are controlled by the image calculator, between the substrate (2) and a separation actuator (20, 21) and are spatially separated from the substrate (2) by the separation actuator (20, 21).
    Type: Grant
    Filed: July 14, 1997
    Date of Patent: March 30, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Luttermann, Edgar Diessel, Winfried Kosch, Walter Weichel
  • Publication number: 20020137091
    Abstract: The process is used for the screening of molecules from molecule libraries with regard to their individual binding behavior towards at least one given ligand. For this purpose the ligands labelled with a fluorescent dye are mixed with the molecule library which is in the form of a suspension. The mixture is plated out on a two-dimensional substrate (2) after the excess, unbound ligands have been washed out. Then the local fluorescence intensities on the substrate are electro-optically identified in a fluorescence microscope (5) and electronically discriminated in accordance with given selection criteria. The objects selected and localised in this way are then sequentially positioned exactly by a displacement, the coordinates of which are controlled by the image calculator, between the substrate (2) and a separation actuator (20, 21) and are spatially separated from the substrate (2) by the separation actuator (20, 21).
    Type: Application
    Filed: July 14, 1997
    Publication date: September 26, 2002
    Inventors: KLAUS LUTTERMANN, EDGAR DIEBEL, WINFRIED KOSCH, WALTER WEICHEL
  • Patent number: 6271342
    Abstract: The invention relates to cytostatics which, by modification with sugar, are tumor-specific. Suitable spacers ensure serum stability and at the same time an intracellular action.
    Type: Grant
    Filed: September 25, 1997
    Date of Patent: August 7, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Georg Lerchen, Karsten von dem Bruch, Uwe Petersen, Jörg Baumgarten, Norbert Piel, Horst-Peter Antonicek, Walter Weichel, Michael Sperzel, Klaus Dieter Bremm
  • Patent number: 5837200
    Abstract: The sorting device is able to sort biological objects, particularly cells or viruses, in liquids as a function of physically measurable criteria or properties. The sorting apparatus is provided with a feed inlet (1) for the biological liquid which branches into a microstructured system of multi-parallel main channels (3) and sorting modules (4) each with a switch unit for distribution to two different outlet channels (19,20). Inside a sorting module (4), at least one sensor (9,10) is arranged on each main channel, and a sorting actuator (12) controlled by the relevant sensor is arranged on each switch unit (11). Finally, each outlet channel (20) is connected to a collecting channel (6) for the unselected biological cells or viruses, and each outlet channel (19) is connected to a collecting channel (5) for the selected cells or viruses. If the cells or viruses are magnetically marked, it is possible to dispense with the sensor (9,10) on the main channels (3).
    Type: Grant
    Filed: May 24, 1996
    Date of Patent: November 17, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Edgar Diessel, Walter Weichel
  • Patent number: 5693539
    Abstract: Improvements in the existing procedures and materials for conduct of high gradient magnetic separation (HGMS) are disclosed. Superior superparamagnetic particles, optionally coated with a polysaccharide or other, usually organic, materials can be prepared in uniform compositions with homogeneous magnetizations. The coating can conveniently be conjugated to a specific binding moiety complementary to a biological material whose purification or separation is desired. In addition, plastic coated matrices which form superior magnetic gradient-intensifying supports are disclosed, along with improved methods and apparatus to conduct HGMS.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: December 2, 1997
    Inventors: Stefan Miltenyi, Andreas Radbruch, Walter Weichel, Werner Muller, Christoph Gottlinger, Klaus Ludwig Meyer
  • Patent number: 5385707
    Abstract: Improvements in the existing procedures and materials for conduct of high gradient magnetic separation (HGMS) are disclosed. Superior superparamagnetic particles, optionally coated with a polysaccharide or other, usually organic, materials can be prepared in uniform compositions with homogeneous magnetizations. The coating can conveniently be conjugated to a specific binding moiety complementary to a biological material whose purification or separation is desired. In addition, plastic coated matrices which form superior magnetic gradient-intensifying supports are disclosed, along with improved methods and apparatus to conduct HGMS.
    Type: Grant
    Filed: January 21, 1993
    Date of Patent: January 31, 1995
    Assignee: Stefan Miltenyi
    Inventors: Stefan Miltenyi, Andreas Radbruch, Walter Weichel, Werner Muller, Christoph Gottlinger, Klaus L. Meyer