Patents by Inventor Walter Weyler
Walter Weyler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9617549Abstract: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.Type: GrantFiled: September 17, 2015Date of Patent: April 11, 2017Assignee: Danisco US Inc.Inventors: Eugenio Ferrari, Carole Harbison, M. Harunur Rashid, Walter Weyler
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Publication number: 20160168582Abstract: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.Type: ApplicationFiled: September 17, 2015Publication date: June 16, 2016Applicant: DANISCO US INC.Inventors: Eugenio FERRARI, Carole HARBISON, M. Harunur RASHID, Walter WEYLER
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Patent number: 9282746Abstract: The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions for generation of peracids. The present invention finds particular use in applications involving cleaning, bleaching and disinfecting.Type: GrantFiled: May 8, 2014Date of Patent: March 15, 2016Assignee: Danisco US Inc.Inventors: Neelam S. Amin, Matthew G. Boston, Richard R. Bott, Maguerite A. Cervin, Edward M. Concar, Marc E. Gustwiller, Brian E. Jones, Klaus Liebeton, Gregory S. Miracle, Hiroshi Oh, Ayrookaran J. Poulose, Sandra W. Ramer, Jeffrey J. Scheibel, Walter Weyler, Gregory M. Whited
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Publication number: 20160002672Abstract: The invention provides for compositions and methods for the production of isoprene, isoprenoid precursor, and/or isoprenoids in cells via the expression (e.g., heterologous expression) of phosphomevalonate decarboxylases and/or isopentenyl kinases.Type: ApplicationFiled: December 20, 2013Publication date: January 7, 2016Inventors: Zachary Q. BECK, Jörg MAMPEL, Guido MEURER, Michael C. MILLER, Karl J. SANFORD, Dmitrii V. VAVILINE, Walter WEYLER, Gregory M. WHITED
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Patent number: 9175294Abstract: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.Type: GrantFiled: January 18, 2013Date of Patent: November 3, 2015Inventors: Eugenio Ferrari, Carole Harbison, M. Harunur Rashid, Walter Weyler
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Publication number: 20150191712Abstract: The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.Type: ApplicationFiled: November 17, 2014Publication date: July 9, 2015Inventors: Richard R. BOTT, Marguerite A. Cervin, James T. Kellis, JR., Joseph C. Mcauliffe, Andrei Miasnikov, Caroline M. Peres, Christopher L. Rife, Derek H. Wells, Walter Weyler, Gregory M. Whited
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Patent number: 8962283Abstract: Described are variants (mutants) of a parent alpha-amylase having alpha-amylase activity and exhibiting altered properties relative to the parent alpha-amylase, and methods of use, thereof.Type: GrantFiled: May 21, 2013Date of Patent: February 24, 2015Assignee: Danisco US Inc.Inventors: Luis G. Cascao-Pereira, Claudine Chang, Clement Choy, James T. Kellis, Jr., Brian E. Jones, Melodie Estabrook, Marc Kolkman, Chris Leeflang, Casper Vroemen, Walter Weyler
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Patent number: 8916370Abstract: The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.Type: GrantFiled: March 30, 2012Date of Patent: December 23, 2014Assignees: Danisco US Inc., The Goodyear Tire & Rubber CompanyInventors: Richard R. Bott, Marguerite A. Cervin, James T. Kellis, Jr., Joseph C. McAuliffe, Andrei Miasnikov, Caroline M. Peres, Christopher Lee Rife, Derek H. Wells, Walter Weyler, Gregory M. Whited
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Publication number: 20140302003Abstract: The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions for generation of peracids. The present invention finds particular use in applications involving cleaning, bleaching and disinfecting.Type: ApplicationFiled: May 8, 2014Publication date: October 9, 2014Applicant: DANISCO US INC.Inventors: Neelam S. Amin, Matthew G. Boston, Richard R. Bott, Maguerite A. Cervin, Edward M. Concar, Marc E. Gustwiller, Brian E. Jones, Klaus Liebeton, Gregory S. Miracle, Hiroshi Oh, Ayrookaran J. Poulose, Sandra W. Ramer, Jeffrey J. Scheibel, Walter Weyler, Gregory M. Whited
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Patent number: 8772007Abstract: The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions for generation of peracids. The present invention finds particular use in applications involving cleaning, bleaching and disinfecting.Type: GrantFiled: December 3, 2004Date of Patent: July 8, 2014Assignee: Danisco US Inc.Inventors: Neelam S. Amin, Matthew G. Boston, Richard R. Bott, Marguerite A. Cervin, Edward M. Concar, Marc E. Gustwiller, Brian E. Jones, Klaus Liebeton, Gregory S. Miracle, Hiroshi Oh, Ayrookaran J. Poulose, Sandra W. Ramer, Jeffrey J. Scheibel, Walter Weyler, Gregory M. Whited
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Publication number: 20140162337Abstract: The invention provides for methods for producing isoprene from cultured cells using various components of the DXP pathway and MVA pathway, or components associated with the DXP pathway and MVA pathway, iron-sulfur cluster-interacting redox polypeptides, and isoprene synthase. The invention also provides compositions that include these cultured cells.Type: ApplicationFiled: July 11, 2013Publication date: June 12, 2014Applicants: The Goodyear Tire & Rubber Company, Danisco US Inc.Inventors: Gopal K. CHOTANI, Joseph C. MCAULIFFE, Michael C. MILLER, Rachel E. MUIR, Dmitrii V. VAVILINE, Walter WEYLER
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Publication number: 20140147902Abstract: The invention provides for compositions and methods for producing isoprene by using recombinantly engineered cells that utilize a system of dual IspG enzymes in addition to isoprene synthase.Type: ApplicationFiled: February 7, 2014Publication date: May 29, 2014Applicants: THE GOODYEAR TIRE & RUBBER COMPANY, DANISCO US INC.Inventors: Rachel E. MUIR, Walter WEYLER
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Patent number: 8685702Abstract: The invention provides for compositions and methods for producing isoprene by using recombinantly engineered cells that utilize a system of dual IspG enzymes in addition to isoprene synthase.Type: GrantFiled: December 22, 2011Date of Patent: April 1, 2014Assignees: Danisco US Inc., The Goodyear Tire & Rubber CompanyInventors: Rachel E. Muir, Walter Weyler
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Publication number: 20140011234Abstract: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.Type: ApplicationFiled: January 18, 2013Publication date: January 9, 2014Applicant: DANISCO US INC.Inventors: Eugenio Ferrari, Carole Harbison, M. Harunur Rashid, Walter Weyler
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Publication number: 20130344542Abstract: Described are variants (mutants) of a parent alpha-amylase having alpha-amylase activity and exhibiting altered properties relative to the parent alpha-amylase, and methods of use, thereof.Type: ApplicationFiled: May 21, 2013Publication date: December 26, 2013Inventors: Luis G. Cascao-Pereira, Claudine Chang, Clement Choy, James T. Kellis, JR., Brian E. Jones, Melodie Estabrook, Marc Kolkman, Chris Leeflang, Casper Vroemen, Walter Weyler
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Publication number: 20130260432Abstract: The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.Type: ApplicationFiled: March 30, 2012Publication date: October 3, 2013Applicant: Danisco US Inc.Inventors: Richard R. BOTT, Marguerite A. Cervin, James T. Kellis, JR., Joseph C. McAuliffe, Andrei Miasnikov, Caroline M. Peres, Christopher Lee Rife, Derek H. Wells, Walter Weyler, Gregory M. Whited
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Patent number: 8507235Abstract: The invention provides for methods for producing isoprene from cultured cells using various components of the DXP pathway and MVA pathway, or components associated with the DXP pathway and MVA pathway, iron-sulfur cluster-interacting redox polypeptides, and isoprene synthase. The invention also provides compositions that include these cultured cells.Type: GrantFiled: June 16, 2010Date of Patent: August 13, 2013Assignees: Danisco US Inc., The Goodyear Tire & Rubber CompanyInventors: Gopal K. Chotani, Joseph C. McAuliffe, Michael C. Miller, Rachel E. Muir, Dmitrii V. Vaviline, Walter Weyler
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Patent number: 8507244Abstract: Variants of Bacillus sp. TS-23 strain alpha-amylases exhibit improved enzymatic performance, including increased thermostability, reduced calcium dependence, increased washing/cleaning performance, and baking ability. Compositions comprising these variants are useful in methods of starch processing, starch liquefaction, fermatation, starch saccharification, cleaning, laundrying, textile desizing, baking, and biofilm removal.Type: GrantFiled: March 2, 2012Date of Patent: August 13, 2013Assignee: Danisco US Inc.Inventors: Andrew Shaw, Sandra Ramer, Scott D. Power, Claudine Chang, Melodie Estabrook, Brian E. Jones, Clement Choy, Marc Kolkmam, Chris Leeflang, Casper Vroeman, Walter Weyler, Karsten Kraugh, Mansi Goyal, Thomas Graycar, Victoria Huang
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Patent number: 8476052Abstract: The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some embodiments, the present invention provides methods and compositions for generation of long chain peracids. Certain embodiments of the present invention find particular use in applications involving cleaning, bleaching and disinfecting.Type: GrantFiled: May 21, 2010Date of Patent: July 2, 2013Assignee: Danisco US Inc.Inventors: Neelam S. Amin, Richard R. Bott, Marguerite A. Cervin, Ayrookaran J. Poulose, Walter Weyler
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Patent number: RE44648Abstract: The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some embodiments, the present invention provides methods and compositions for generation of long chain peracids. Certain embodiments of the present invention find particular use in applications involving cleaning, bleaching and disinfecting.Type: GrantFiled: June 15, 2012Date of Patent: December 17, 2013Assignee: Danisco US Inc.Inventors: Neelam S. Amin, Richard R. Bott, Marguerite A. Cervin, Ayrookaran J. Poulose, Walter Weyler