Abstract: The present disclosure relates to compositions and methods for reducing expression of MYC gene in a cell. In some embodiments, an expression repressor comprises a targeting moiety that binds a MYC promoter, anchor sequence, or super-enhancer. In some embodiments, the expression repressor comprises an effector moiety that represses transcription or methylates DNA. Systems comprising two expression repressors are also disclosed. The compositions can be used, for example, to treat cancers such as HCC or NSCLC.

Abstract: Articulator (1) for holding dental models with a stationary base (2) for the lower jaw model and an upper part (3) which is attached thereto in such a way that it can be swiveled, for holding the upper jaw model, with mountings (11, 12) in the upper part and the base for the jaw models, the mounting (11) for the upper jaw model being designed in such a way that it can be adjusted at random along three planes perpendicular to each other and can also be locked in any of the positions, and with the mountings (11, 12) being arranged such that the distance between them can be adjusted and locked.

Abstract: PCT No. PCT/DE78/00015 Sec. 371 Date Apr. 1, 1979 Sec. 102(e) Date Mar. 28, 1979 PCT Filed July 26, 1978 PCT Pub. No. WO79/00076 PCT Pub. Date Feb. 22, 1979The invention relates to a device for producing a working model for making dental prostheses, which comprises a base presenting an open portion on both sides and features a hollow portion adapted to the shape of the jaws and presenting ribs on both inner surfaces, said ribs acting as retaining members for the plaster model and having the shape of ramps with a constant slope from top to bottom, the hollow portion widening from bottom to top. Between the inner wall of the base and its back wall is a horizontal plate which has roughly the shape of a parabola, said horizontal plate being set off downwards and with respect to the top edge of the wall.