Abstract: In one version of the invention, an apparatus intended for determining the disintegration time of rapidly disintegrating tablets is designed with a disintegration cell having two liquid inlets and outflow from the top. Visualization of tablet inside the disintegration cell is conducted using a camera aided by a base light source and images captured using a computer or any other recording system. Disintegration medium is introduced into the disintegration cell through both inlets to produce a swirling motion and images of the tablet disintegration process are captured. The captured images are analyzed in real-time or off-line, to determine the tablet disintegration time. A visual non-recording method using projected image may also be used.

Abstract: In one version of the invention, an apparatus intended for determining the disintegration time of rapidly disintegrating tablets is designed with a disintegration cell having two liquid inlets and outflow from the top. Visualization of tablet inside the disintegration cell is conducted using a camera aided by a base light source and images captured using a computer or any other recording system. Disintegration medium is introduced into the disintegration cell through both inlets to produce a swirling motion and images of the tablet disintegration process are captured. The captured images are analyzed in real-time or off-line, to determine the tablet disintegration time. A visual non-recording method using projected image may also be used.

Abstract: A low melting binder composition for preparation of pharmaceutical tablets and/or granules which comprises a polymer and a hydrophobic meltable binder.

Abstract: Topical and/or transdermal bioactive compound delivery system The present invention provides a topical and/or transdermal bioactive compound delivery system comprising a non-aqueous matrix, the matrix comprising a water-sensitive bioactive compound. In particular, the matrix comprises a three-dimensional polymeric network comprising at least a co-polymer, at least a cross-linking agent, and at least a non-aqueous and/or non-volatile solvent and wherein the water-sensitive bioactive compound is housed by the three-dimensional network. Even more in particular, the matrix comprises a co-polymer of N-vinylacetamide and sodium acrylate aluminium chloride; N-methyl-2-pyrrolidone; propylene glycol; glycerine; and at least a water-sensitive bioactive compound.